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Biomedical subjects

K Sagreiya

Publications and source records attributed to K Sagreiya.

At least 19 recordsLinked to original sources

Incidence of osteomalacia in fractures of the proximal end of femur.

Twenty-six cases of fractures of the proximal end of the femur were studied to assess the role of osteomalacia. Biochemical, radiological and histological investigations were carried out in all the cases. Osteomalacia, commonly subclinical, was found to be the underlying cause in 65 per cent of cases. Histological analysis of iliac crest biopsy was the only reliable way of diagnosing subclinical osteomalacia.

Female↗

The microanatomy of trabecular bone loss in normal aging men and women.

Histomorphometric changes in normal bone were investigated using tissue from the ilium of 86 women and 98 men, aged 20-90 years. While loss of trabecular volume was common to both sexes, the histologic basis for the loss differed. Decreased formation (expressed primarily as static indices) seemed to be the principal factor in bone loss in men; in women these features remained unchanged, suggesting that increased resorption was the principal factor. Bone loss in women was principally attributable to the total removal of individual trabeculae; conversely in men, there was generalized attenuation of trabecular bone. Similar findings in bone tissues of vertebral bodies suggest that differences in bone remodelling between the sexes produce different patterns of bone loss as a sequence of aging.

Adult↗

Perinatal mortality--report of a hospital based study.

The perinatal mortality rate (PNMR) per 1000 births is reported in 27,394 consecutive births. It was 75.6, of which 40.0 were neonatal deaths and 35.6 were fetal losses. The PNMR was significantly higher at the two extremes of maternal age, in parity five and above, and with a previous history of fetal or neonatal loss. Other maternal contributing factors were antepartum haemorrhage, hydramnios and infections. One-third of the babies weighed 2500 g or less. The PNMR dropped precipitously from 340.48 in the birth weight group 1501 to 2000 g, to 46.6 in the group 2001 to 2500 g, indicating a cut-off point at 2000 g for a baby at high risk needing special care. The common necropsy causes of death were asphyxia (24.33%), pulmonary conditions (20.02%), congenital malformations (13.6%), and infections (6.19%). No cause of death could be detected at necropsy in 22.12% and no clinico-pathological cause of death could be assigned in 26.76% of deaths. A majority of deaths due to asphyxia could have been prevented by better antenatal and intranatal care. Low birth weight was an important cause of perinatal deaths, and better maternal nutrition and antenatal care could play an important role in reducing this.

Birth Weight↗

Leiomyoblastoma.

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Child↗