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Biomedical subjects

K Saji

Publications and source records attributed to K Saji.

At least 19 recordsLinked to original sources
PubMed1992

[Experience in the treatment of acute fulminating myasthenia gravis].

During past 15 years, 188 myasthenia gravis (MG) patients underwent thymomectomy or thymectomy with extended resection of the adipose tissue around the thymus in our institution. Four of 188 patients (2%) had to be given respiratory support within 2 months after the onset of MG. We defined this MG as the acute fulminating type. There were 2 male and 2 female patients, ranging in age from 22 to 44 years (average, 32.5 years). Three of these patients had thymoma. One of these patients was post-thymomectomy myasthenia gravis and another patient was d-penicillamine induced myasthenia gravis. Two patients admitted on respirator for respiratory crisis. All patients underwent operation within 2 weeks after admission. The duration of respiratory support ranged from 10 to 120 days (mean 44) after operation. The period of the hospital stay ranged from 8 months to 2 years 1 month (mean 1 year 5 months). During acute stage after operation, the patients needed ACTH, steroid, immunosuppressants (azathioprine, Bredinin) and plasma pheresis depending on their severity of myasthenic symptoms. In 2 patients dose of steroid could be reduced without deterioration of the symptoms. They are doing well with small dose of steroid. In one patient plasma pheresis was performed 6 years after thymectomy. Various symptoms due to myasthenia gravis and rheumatoid arthritis has recurred 10 years after thymectomy. The titer of acetylcholine receptor antibody of this patient has been continuing in high level.

Acute Disease↗
PubMed1980

Studies on the difference of background mucosa among single advanced carcinoma and benign diseases of the large intestine, and familial polyposis coli.

The entire lengths of fixed specimens from 17 single advanced carcinomas of the colon (Cancer Group), four benign lesions (Benign Group), and four familial polyposis coli (Polyposis Group) were step-sectioned. It was found that the tubules of the basal cells were densely packed with rather a small number of goblet cells in the cancer and benign lesion specimens, but clear and loose with completely differentiated goblet cells in the polyposis coli specimens. Microscopic adenomas that were macroscopically unrecognizable and only microscopically detectable were found in 16 lesions in the Cancer Group, one lesion in the Benign Group, and in numerous lesions in the Polyposis Group. All of them developed from the basal cells. These findings indicate that the colonic mucosa of patients in the Cancer and Benign Groups is similar, but differs from that of the Polyposisis Group, and that microscopic adenomas are not uncommon in the Non-Polyposis Groups (Cancer and Benign Groups), findings which were not previously known.

Adenoma↗
PubMed1978

Surgical treatment of annuloaortic estasia: experience in 7 consecutive patients.

Seven patients with annuloaortic ectasia were treated according to the method described by Bentall and De Bono. A Björk-Shiley valve in a composite graft was the prosthesis of choice and was used in all patients except 1, who received a Starr-Edwards valve. Profound topical cooling without selective coronary perfusion was applied in 5 patients for myocardial preservation during aortic occlusion. The was 1 operative death and 1 late death, the latter from cerebral thromboembolism. Five survivors have been followed from 1 year 5 months to 2 years 10 months with an average follow-up of 2 years. Excellent results were obtained in all survivors, their physical capabilities putting them in Class I of the New York Heart Association Functional Classification. Postoperative aortograms showed no signs of kinking or compression of vascular prostheses nor abnormalities of prosthetic calves. A modified technique to secure graft fixation is discussed.

Adolescent↗
PubMed1977

Sound spectroanalytic diagnosis of malfunctioning prosthetic heart valve.

Sound spectroanalysis was carried out for diagnosis of malfunctioning prosthetic heart valves in 50 cases, which consisted of 31 mitral, 14 aortic, 4 mitral+aortic and 1 tricuspid valve replacements with the age ranging from 17 to 57 years. Types of prosthetic valves used in this series were Starr-Edwards silicon ball valves, metal ball valves, disc valves, Kay-Shiley valves, Smeloff-Cutter valves and a Björk-Shiley valve. The system used in this study consisted of a moving coil microphone, a preamplifier, a filter (160/24 db octave) and a sound spectrograph (Rion Co. S.G. (7). Contour sound spectrograms (SSG) were drawn and peak frequency, wave pattern and frequency-intensity curves were investigated as characteristics of implanted valvular function. Peak frequencies of valvular opening and closing sounds were recorded between 1800 to 5000 Hz and differed according to the types of prosthesis. In mitral+aortic valve replacements, valvular sounds of two prostheses were clearly separated and this finding was very useful for determining the prosthesis which fell into malfunction. Decrease in peak frequency of valvular sounds or abnormal wave patterns in contour SSG were observed in 9 cases (18%). Of 9 cases, 4 cases underwent re-replacement and 2 cases died of congestive heart failure. Operative or autopsy findings gave proof to the findings in sound spectroanalysis.

Adolescent↗