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Biomedical subjects

K Sakane

Publications and source records attributed to K Sakane.

47 records · Page 3Linked to original sources
PubMed1984

Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. II. Synthesis and structure-activity relationships in the aminopyrimidine series.

The synthesis and the antibacterial activity of 7 beta-[2-(aminopyrimidinyl)-2-oxyiminoacetamido]cephalosporin s with various substituents at the 3-position in the cephem nucleus are described. The 7 beta-[2-(4-aminopyrimidin-2-yl)-2 -methoxyiminoacetamido]cephalosporin derivative (1) showed significantly higher activity than the corresponding 2-aminopyrimidin-4-yl derivative (2) against Gram-negative bacteria. It was also higher in potency against Escherichia coli and Serratia marcescens than the aminopyridyl compound (4).

Bacteria↗
PubMed1984

Studies of 7 beta-[2-(aminoaryl)acetamido]-cephalosporin derivatives. III. Synthesis and structure-activity relationships in the aminothiadiazole series.

The synthesis and in vitro antibacterial activity of 7 beta-[2-(5-amino-1,2,4-thiadiazol-3-yl)-2-oxyiminoacetamido] cephalosporins with various substituents at the 3-position in the cephem nucleus are described. Aminothiadiazolyl cephalosporins having pyridiniomethyl groups at the 3-position exhibited excellent activity against all organisms, particularly against Pseudomonas aeruginosa.

Bacteria↗