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Biomedical subjects

K Sandhage

Publications and source records attributed to K Sandhage.

At least 19 recordsLinked to original sources
PubMed1994

[Granulomatous endocarditis caused by streptococcus].

Two cases of granulomatous endocarditis are reported. The patients developed aortal endocarditis refractory to antibiotics. Therefore, aortal valve replacement was performed. In both cases, Streptococcus viridans was demonstrated in culture and bacterioscopically to be the cause of infection. Histological examination of the valves showed characteristic endocarditis with fibrinoid necrosis and histiocytic granulomas. Streptococci were found in the cytoplasm of macrophages. The possible causes of this special form of infectious endocarditis are discussed.

Adolescent↗
PubMed1994

Reactive arthritis due to Salmonella enteritidis complicated by carditis.

Reactive arthritis following infection with enteropathogenic bacteria is usually a self-limiting disease that disappears after a few months without sequela. We describe two girls who developed carditis shortly after the onset of reactive arthritis due to infection with Salmonella enteritidis. The carditis presented with fatigue and arrhythmia and involved the aortic valve in both patients leading to definite aortic regurgitation in one. A similar pattern of cardiac involvement is found in other spondyloarthropathies, including Reiter's syndrome and ankylosing spondylitis. We conclude that Salmonella reactive arthritis may be complicated by carditis.

Adolescent↗
PubMed1989

[Secondary immunopathogenesis in myocarditis, diseases of the heart muscles and infarct-associated arrhythmia in childhood and adulthood].

In histologically proven or clinically diagnosed perimyocarditis in children and adults alterations in cellular and humoral effector mechanisms are demonstrable: OKIaI-positive B- or activated T-lymphocytes are increased in the peripheral blood, whereas natural killer cell activity is reduced. Antibodies are directed to the membranes of isolated human atrial myocytes and, to a lesser extent with lesser specificity, to endothelial cells and to the extracellular matrix. AMLAs are of diagnostic relevance if they belong to the IgM class, indicating a recent humoral immune stimulation and, if they fix complement, indicating a functional property which is complement associated lysis of target cells. Immunohistological studies demonstrate fixation of immunoglobulins to the autologous biopsy specimens, which are diagnostic only if they also belong to the IgM class and fix complement. In acute rhythm disturbances in the context of a recent "common cold", similar humoral immune reactions can be found in children, which are compatible with a secondary immunopathogenesis after viral illness involving the myocardium.

Adult↗
PubMed1982

Tachyarrhythmic syncopes in children with structurally normal hearts with and without QT-prolongation in the electrocardiogram.

Forty children with presumed ventricular tachyarrhythmic syncopes in the absence of structural heart disease were studied. Twenty-nine patients, one of whom was deaf, had a prolonged QT-interval in the resting electrocardiogram (Group 1); eleven patients had a normal QT-interval (Group 2). The median QTc-interval vas 0.51 s in Group 1 and 0.40 s in Group 2. Familial occurrence suggesting autosomal dominant inheritance was found in 21 of 28 normally hearing patients in Group 1 and in 2 of 11 patients in Group 2. Syncopes were definitely stress-induced in 22 patients in Group 1 and in all 11 patients in Group 2. Of 23 patients in Group 1 in whom an electrocardiogram was obtained during physical exercise, only one showed severe ventricular dysrhythmia. In contrast, all eleven patients in Group 2 developed severe ventricular dysrhythmia with exercise. Treatment with beta-blocking medication prevented further syncopes in 15 of 19 patients with several previous attacks in Group 1 and in 3 of 5 patients of Group 2. Four of the 29 patients in Group 1 died suddenly and one more remained apallic after an attack. Of the 11 patients in Group 2, four died suddenly and one retains severe cerebral damage after resuscitation from ventricular fibrillation. We conclude that, besides the group of patients with the long QT-syndrome, there may be a distinct group of patients with a consistently normal QT-interval and severe ventricular dysrhythmia with exercise. Patients of both groups are threatened by sudden death and are improved by treatment with beta-blocking medication.

Adolescent↗
PubMed1981

Impedance cardiography in normal children.

Cardiac output, cardiac index (cardiac output/body surface) and stroke volume were investigated in 20 normal children by means of impedance cardiography. Significant differences were found in the mean values of cardiac output and cardiac index between both sexes, as well as in means of cardiac index between younger and older children. The obtained data generally agreed with the results of other investigators performing the examination by using the same technique and other methods.

Adolescent↗
PubMed1981

Estimation of the correlation between the transcutaneous aortic flow velocity curve and impedance cardiogram in normal children.

83 measurements of stroke volume from an impedance cardiogram and of the corresponding area under the systolic complex of the aortic flow velocity curve obtained by means of the transcutaneous ultrasound Doppler device were carried out in 15 normal children. Between the "ideal" complexes and those requiring a little reconstruction (below 10% of maximal height of the given complex) and corresponding stroke volumes, significant correlation and regression coefficients were found. It has been suggested that the aortic flow velocity curve obtained by means of the transcutaneous ultrasound nondirectional Doppler device would be helpful in approximately estimating the stroke volume in normal children.

Adolescent↗
PubMed1980

Aortic blood flow patterns: a transcutaneous Doppler study.

In 35 normal children some variables of the aortic arch blood flow were studied by transcutaneous ultrasonic Doppler technique. Mean values for peak velocity (V), acceleration in early systole (Acc), duration of the acceleration phase, as well as the area under the early phase of flow systolic complex (S) were calculated. A significant difference in S value was found between girls and boys. Some significant correlation and regression coefficients were found between the mentioned indices of the aortic blood flow on the one hand, and the weight, height, age and heart rate on the other. The highest values for the correlation coefficients occurred in girls between V and Acc on the one hand, and the weight of the subjects on the other.

Adolescent↗
PubMed1978

[Diagnosis and treatment of infantile cardiac insufficiency (author's transl)].

Congenital vitium cordis and myocardial diseases, rare arrhythmias and other factors are the causes of heart failure which imposes a life-threatening clinical condition in infancy and childhood with a sometimes characteristic, but often also unspecific symptomatology. An intensive program of general and medicinal measures is required of which digitalis therapy is the central feature. In addition, diuretics, catecholamines and buffer substances are essential among other things. The success and duration of treatment depends on the primary disease.

Acid-Base Equilibrium↗