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Biomedical subjects

K Sasaguri

Publications and source records attributed to K Sasaguri.

4 recordsLinked to original sources
PubMed1995

Inflammatory cytokine gene expression in human periodontal ligament fibroblasts stimulated with bacterial lipopolysaccharides.

The effects of Porphyromonas gingivalis lipopolysaccharide (P-LPS) and Escherichia coli lipopolysaccharide (E-LPS) on the gene expression and production of inflammatory cytokines of human periodontal ligament fibroblasts (HPLF) were examined by a Northern (RNA blot) assay and enzyme-linked immunosorbent assay, respectively. mRNAs for interleukin-6 (IL-6), IL-8, and transforming growth factor beta (TGF-beta) were detected in HPLF cells, but IL-1 alpha, IL-1 beta, tumor necrosis factor alpha, transforming growth factor alpha, and granulocyte-macrophage colony-stimulating factor were not detected by reverse transcription-PCR. The expression of TGF-beta mRNA was not influenced by either LPS. P-LPS (1 to 10 micrograms/ml) and E-LPS (100 micrograms/ml) markedly stimulated the expression of IL-6 and IL-8 mRNAs compared with the control. The synthesis of IL-6 and IL-8 was also stimulated by 10 and 100 micrograms of both LPSs per ml, but IL-8 synthesis was not stimulated with E-LPS at 1 microgram/ml. Secretion of IL-6 and IL-8 into the culture medium was detected at 6 and 3 h, respectively, after exposure to P-LPS (10 micrograms/ml). These findings suggested that P. gingivalis leads to periodontal tissue destruction and alveolar bone resorption through IL-6 and IL-8 released from HPLF cells stimulated with its LPS.

Alkaline Phosphatase↗
PubMed1990

[Importance of posterior tooth-to-denture base discrepancy in the development of skeletal open-bite malocclusion].

This paper describes the relationship between the development of skeletal open-bite malocclusion and the tooth-to-denture base discrepancy. The cases which have a severe skeletal open-bite malocclusion are presented to evaluate the causing factor of the anterior open-bite. The anterior open-bite was associated with inferiorly positioned maxillary molars caused by the squeezing out effect of the tooth-to-denture base discrepancy, especially those in posterior part of dentition (posterior discrepancy), which provided a less steep maxillary occlusal plane in the denture frame. It was suggested that the posterior discrepancy induced a descending movement of the posterior teeth followed by a change of the occlusal plane and this effect of the posterior discrepancy was important factor in developing anterior open-bite malocclusion.

Cephalometry↗
PubMed1989

Computed cephalography using laser scan system.

A new imaging system with applications in dentistry has been developed which uses recent advances in both electronic and computer technology. The cephalometric radiogram is based on a newly developed laser scan system offering these characteristic features: 1. A clearer image with a wide latitude can now be obtained compared with the cephalometric radiograms taken by the conventional method. 2. Various imaging processes are available through computer enhancement which enable visualization of the sites of dense and thin bones and even the anatomical morphology of the soft tissues. Such images could be easily observed regardless of the purpose of the radiogram. 3. Data are reduced by conversion into digital signals which can be stored in the computer for long periods. 4. Exposure dose is reduced.

Cephalometry↗