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Biomedical subjects

K Schaefer

Publications and source records attributed to K Schaefer.

At least 91 records · Page 5Linked to original sources
PubMed1985

Optimum dialysis treatment for patients over 60 years with primary renal disease. Survival data and clinical results from 242 patients treated either by haemodialysis or haemofiltration.

An analysis of the data of 180 haemodialysis patients and 62 haemofiltration patients over 60 years of age when commencing treatment, clearly shows that this age group of patients (when suffering from primary renal disease) has a very good chance of surviving many years when treated with either haemodialysis or haemofiltration. This refers also to patients being older than 75 or 80 years, who have survival rates of 50 per cent after five years and three years respectively. The presented data further indicate that chronic haemofiltration seems to be the superior treatment when compared with acetate haemodialysis for the treatment of elderly renal patients, as the survival rates are at any chosen time interval higher with haemofiltration than with haemodialysis.

Age Factors↗
PubMed1984

Effect of diets containing varying concentrations of essential fatty acids and triglycerides on renal function in uremic rats and NZB/NZW F1 mice.

Influences of essential fatty acids (EFA) and triglycerides as reasons for the progression of chronic renal failure are still in debate. We studied the outcome of four diets containing different concentrations of triglycerides and EFA in 5/6 nephrectomized rats and in NZB/W mice up to 45 weeks. The results showed no significant differences in the outcome of survival rate, proteinuria, urea, and creatinine levels as well as histological findings in the different groups of both animal models. We conclude that diets containing EFA up to C18:2 or being free of EFA or that triglyceride-enriched diets have no influence on the natural course of the renal disease in these both experimental models.

Animals↗
PubMed1983

[Analysis of antibiotic therapy in 500-bed hospital: indications, administration and possibilities of cost reduction].

The introduction of a justification form in a 500-bed acute hospital before starting therapy with antibiotics resulted in a more than 30% decrease of current antibiotics costs. The cost reduction was mainly caused by reduced consumption of very expensive antibiotics. Moreover, analysis of the justification form revealed that more than 20% of diseases such as pneumonia, bronchitis, postsurgical complications, or skin and bone infections were diagnosed and treated without sufficient clinical and bacteriological documentation. The use of a justification form for antibiotics is therefore not only useful for cutting costs, but also for educating physicians in how to administer rational prophylaxis and therapy with antibiotics.

Antibodies↗
PubMed1983

Failure to show a temperature-dependent vascular stability during hemofiltration.

The effect of different blood temperatures on the vascular stability during hemofiltration was evaluated in 10 patients being in the regular chronic hemofiltration program. In contrast to recent data, no differences could be observed with regard to the heart rate, systolic blood pressure or mean arterial pressure, when the blood returned to the patient either with a temperature of 34.68 degrees C or 36.22 degrees C. According to these data it is therefore presently not justified to consider differences in the blood temperature as a critical determinant for the vascular stability during HF.

Adult↗
PubMed1982

Successful hemodialysis for acute renal failure in late pregnancy.

The occurrence of an acute renal failure during pregnancy does not necessarily imply the termination of the gestation. A 21-year-old pregnant woman was successfully dialyzed because of an acute azotemia developing in the 27th week of pregnancy. After repeated hemodialysis treatments the renal function recovered and the patient gave birth to a healthy child at full term. It is suggested that hemodialysis should be performed as often as possible (twice daily) in order to avoid any dramatic changes of the serum chemistry and the fluid content of the body. Furthermore, such a regimen allows the regular intake of calories, which is considered as especially important in such an event.

Acute Kidney Injury↗
PubMed1981

[Vitamin D 1980--a stocktaking (author's transl)].

Vitamin D3 and its various metabolites have a central position in the regulation of the calcium- and phosphorus metabolism. Of special importance is 1,25-dihydroxyvitamin D3, which is almost exclusively synthesized in the kidney. Its production is dependent upon several hormonal stimuli and of course occurs normally only in intact renal tissue. The multifactorial regulation of its formation implies that a variety of diseases could cause disturbances in the metabolism of vitamin D. 1,25-dihydroxyvitamin D3 exerts its biological effects not only at the intestine, bone and kidney, but as well presumably in organs as the parathyroid glands, hypophysis, pancreas and skin. 24,25-dihydroxyvitamin D3--although its biological value is still in debate--represents possibly a second vitamin D-hormone of importance. Inspite of intensive research work the metabolic fate of vitamin D3 and its full biological significance is not yet entirely understood.

24,25-Dihydroxyvitamin D 3↗
PubMed1981

Digoxin-quinidine interaction in patients with renal failure.

Investigations were performed in order to study whether or not quinidine would exert similar effects on the serum digoxin concentration in patients with renal failure as in normal subjects. Fourteen out of fifteen patients showed a significant increase of the serum digoxin level after four days of quinidine application. This indicates, that the quinidine effect is not solely caused by a decrease of the renal digoxin clearance, although nine patients, not being hemodialysed, revealed a correlation between their creatinine clearance and the rise of the serum digoxin concentration after quinidine. As however, the patients on hemodialysis did not show higher digoxin levels than those treated conservatively, it is suggested that the degree of the uremic intoxication might be responsible for the observed correlation.

Acetyldigoxins↗