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Biomedical subjects

K Sedláková

Publications and source records attributed to K Sedláková.

6 recordsLinked to original sources
PubMed1989

[Antihypertensive therapy using metipamide VUFB].

In a group of 17 patients with mild hypertension the antihypertensive effect of Metipamide VUFB was investigated. In the course of fourteen weeks' treatment the mean blood pressure declined from 20.5/13.3 kPa to 17.3/11.2 kPa and at the end of the investigation the diastolic blood pressure readings were normal in all patients. Echocardiography revealed a slight decline of the total peripheral resistance. The natriuretic effect was confirmed which is in the foreground of the antihypertensive action of metipamide. Investigation of side-effects of treatment revealed in 12 patients hypokaliaemia calling for substitution treatment, or when used clinically, a combination with a potassium sparing diuretic. There was a rise of the AST and ALT activity. The renal function did not change. The clinically significant drop of serum uric acid was striking. Glucose tolerance and serum lipids were not affected.

Adult↗
PubMed1989

[The effect of metipamide on levels of sodium and potassium in erythrocytes].

The effect of metipamide on the level of Na+ and K+ in erythrocytes was studied in patients with essential hypertension. The control series consisted of healthy normotonics. In normotonics Nai+ and Ki+ were not affected in vitro, whereas in hypertonics Nai+ was found to be significantly increased (p less than 0.01) and Ki+ decreased (p less than 0.025). In vivo two subgroups of hypertonics were established: a) hypertonics with normal content of Nai+ (6.9 +/- 0.3.10(-3) mol/l) and b) hypertonics with increased content of Nai+ (9.2 +/- 0.3.10(-3) mol/l compared to 7.3 +/- 0.1.10(-3) mol/l, p less than 0.005). With respect to the given heterogeneity of the series, the response to metipamide treatment failed to be uniform. A part of the patients responded to therapy by diminished Nai+, manifesting one of the potential mechanisms of the antihypertensive effect of metipamide. The significant drop of Ki+ recorded in both subgroups of patients in the course of treatment demonstrated the potassium depleting effect of the drug.

Adult↗
PubMed1988

Serotonin metabolism and platelet aggregation under antihypertensive treatment with nitrendipine.

The effect of antihypertensive treatment with nitrendipine (10-40 mg/day) on serotonin metabolism and platelet aggregation was investigated in 13 hypertensive patients over a 6-month period. Normalization of elevated blood pressure was achieved [systolic blood pressure (SBP): 167 +/- 4 to 148 +/- 4 mm Hg, p less than 0.01; diastolic blood pressure (DBP): 108 +/- 2 to 95 +/- 3 mm Hg, p less than 0.01; chi +/- SEM before and after the treatment]. The decrease in plasma serotonin (5-HT) levels (354 +/- 140 to 179 +/- 49 nmol/L) and the platelet 5-HT content (9.6 +/- 3.5 to 2.8 +/- 0.9 nmol/10(9) Tro) was observed. Urinary 5-HT and 5-hydroxyindolacetic acid output did not show significant changes. Although the platelet aggregation decreased only moderately, a positive correlation was found between the 5-HT levels in platelet-poor plasma and platelet aggregation indices I (r = 0.699; p less than 0.001). The impaired 5-HT metabolism parameters (high platelet serotonin content and low 5-HT urinary output) in a washout period were normalized under the treatment with nitrendipine. It is concluded that the interaction with serotonergic metabolism could participate in antihypertensive mechanisms of nitrendipine. This effect is of clinical and theoretical importance when taking into account 5-HT atherogenic and mitogenic activity.

Aged↗