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Biomedical subjects

K Shin

Publications and source records attributed to K Shin.

80 records · Page 5Linked to original sources
PubMed1983

[Localized amyloidosis of the ureter: report of a case].

A case of primary amyloidosis of the ureter is presented. The patient was a 48-year-old woman with a 5-year history of asymptomatic macrohematuria. Roentgenographic examination showed left hydronephrosis and stenosis of the left distal ureter. Histological examination of the biopsied specimen during the operation revealed no malignancy; and, left partial ureterectomy and uretero- vesiconeostomy was performed. Congo red stain proved amyloid deposition after surgery. Rectal biopsy was negative for amyloid; and, other laboratory findings were within normal range. Thus it was diagnosed as a primary localized amyloidosis of the ureter. Importance of intraoperative histologic examination was discussed. This is the 22nd case in the literature.

Amyloidosis↗
PubMedDate not supplied

Unique use of botulinum toxin to decrease adductor tone and allow surgical excision of vulvar carcinoma.

Here, we present the case of an 86-year-old woman with vulvar carcinoma requiring surgical resection and with Parkinson's disease with severe spasticity and contractures of the lower extremities. Because of the patient's severe contractures and spasticity (her knees could only be separated by 2 cm with sustained abducting force), surgical positioning and access to the vulva were impossible. The patient was admitted, intending to undergo surgery after injection with botulinum toxin (BTX) to hip adductors and intensive physical therapy. After confirmed healed hip arthroplasty, the patient underwent BTX injection (400 U) to her bilateral adductor brevis, adductor longus, adductor magnus, and semimembranosus and semitendinosus muscles on day 2 of her hospital stay. On day 3, a physical therapist began a twice-a-day stretching program. An adjustable abduction brace was custom-made to provide sustained stretching. On day 9, the patient underwent wide local excision of vulvar carcinoma with the abductor brace in place. The patient tolerated the surgery well and was discharged home on day 11 with continuous physical therapy. Upon discharge, the distance between the patient's knees was 14 cm. This unique case demonstrated a new indication for BTX treatment in the preoperative setting to allow surgical positioning and access.

Aged↗
PubMedDate not supplied

The influence of controlled occlusal overload on peri-implant tissue. Part 3: A histologic study in monkeys.

The influence of experimental occlusal overload on peri-implantitis in monkeys (Macaca fascicularis) has been examined to explain the pathology of the disease that develops in the tissue around osseointegrated implants. In the first article of this series, it was reported that bone resorption was not observed around implants when occlusal trauma was produced by a super-structure that was in supraocclusal contact with an excess occlusal height of approximately 100 microns, provided there was no inflammation in the peri-implant tissue. In the second part of the study, experimental inflammation was created in the peri-implant tissue, and occlusal overload was produced by a superstructure with an excess occlusal height of 100 microns. Notable bone resorption was observed around the implant with the passage of time. These results suggested that, in addition to the control of inflammation in peri-implant tissue, traumatic occlusion may play a role in bone breakdown around the implant. In the present study, while the peri-implant tissue was kept in an inflammation-free state, bone level changes around the implants were investigated when various levels of traumatic force were exerted. The supraoccluding prostheses were defined as excessively high by 100 microns, 180 microns, and 250 microns, respectively. The heights were determined with an image analysis device, and the bone responses around the implants induced by the traumatic forces were investigated. The results showed that bone resorption around implants tended to increase with 180 microns or more excessive height of the superstructure. This suggests that the threshold of excessive height of the superstructures at which peri-implant tissue breakdown may start is approximately 180 microns. It is also suggested that there is a possibility of bone resorption around the implants caused by excess occlusal trauma, even when there is no inflammation in peri-implant tissue.

Alveolar Bone Loss↗
PubMedDate not supplied

The influence of controlled occlusal overload on peri-implant tissue: a histologic study in monkeys.

This study examined the influence of controlled occlusal overload on an implant. An experiment was conducted on five crab-eating monkeys (Macaca fascicularis) in which overload with no inflammation in the peri-implant tissues was modeled. Two osseointegrated implants were placed into each monkey. After 3 months of osseointegration, superstructures that were excessive by about 100 microns were mounted on the implants, and a traumatic occlusal force was experimentally delivered to its implant from the lingual to the buccal side. This procedure was performed under conditions of good oral hygiene. The monkeys received an excessive occlusal force for 1 to 4 weeks and were then immediately sacrificed. The results showed that the implants remained firmly integrated with bone, and all of the subjects that received excessive occlusal force for 1 to 4 weeks showed an absence of gross bone loss. These results suggest that conditions of occlusal force created by excessively high implant-supported superstructures may not destroy the peri-implant tissues.

Animals↗