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Biomedical subjects

K Siddiqi

Publications and source records attributed to K Siddiqi.

6 recordsLinked to original sources

The bleach microscopy method and case detection for tuberculosis control.

The World Health Organization (WHO) and the International Union Against Tuberculosis and Lung Disease (The Union) recommend direct sputum smear microscopy for tuberculosis (TB) case finding in resource-poor settings. This method is associated with poor sensitivity. Digestion of sputum with bleach prior to smear preparation has been reported to increase sensitivity. Some workers, having reviewed the relevant literature, have called for the WHO and The Union to advocate for a shift to this methodology for TB case finding. This article highlights deficiencies in the scope and detail of available evidence, and cautions against the premature, and possibly counter-productive, adoption of so-called 'bleach microscopy'. Further well-guided research is required to answer policy-relevant gaps in our knowledge about this promising technology.

Humans↗

The transmission of tuberculosis in confined spaces: an analytical review of alternative epidemiological models.

Tuberculosis (TB) is a disease that is closely associated with poverty, with transmission occurring in situations where infected persons are in close contact with others in confined spaces. While it is well recognised that overcrowding increases the risk of transmission, this increased risk has not been quantified and the relationship between overcrowding and duration of exposure is not well understood. This paper analyses three epidemiological models that have been used to predict the transmission of airborne disease in confined spaces: the Mass Action model, Riley, Murphy and Riley's model and Gammaitoni and Nucci's model. A study is presented to demonstrate the range of applicability of each model and show how they can be applied to the transmission of both TB and diseases with short incubation periods such as measles. Gammiatoni and Nucci's generalised formulation is shown to be the most suitable for modelling airborne transmission in ventilated spaces, and it is subsequently used in a parametric study to evaluate the effect of physical and environmental factors on the rate of disease transmission. The paper also presents reported quanta production data for several TB outbreaks and demonstrates that the greatest risk of TB infection is during clinical procedures that produce large quantities of aerosol, such as bronchoscopy or intubation.

Disease Transmission, Infectious↗

On the psychophysics of the shape triangle.

We earlier introduced an approach to categorical shape description based on the singularities (shocks) of curve evolution equations. We now consider the simplest compositions of shocks, and show that they lead to three classes of parametrically ordered shape sequences, organized along the sides of a shape triangle. By conducting several psychophysical experiments we demonstrate that shock-based descriptions are predictive of performance in shape perception. Most significantly, the experiments reveal a fundamental difference between perceptual effects dominated by when shocks form with respect to one another, versus those dominated by where they form. The shock-based theory provides a foundation for unifying tasks as diverse as shape bisection, recognition, and categorization.

Algorithms↗

Tuberculosis and poverty in the ethnic minority population of West Yorkshire: an ecological study.

The rising incidence of TB in the UK in the last decade has been attributed mainly to the persistently high TB rates amongst ethnic minority groups. The epidemiology of TB in these groups is presently poorly understood. The aim of this ecological study was to investigate the relationship between TB and poverty in the South Asian ethnic groups. TB notification rates in South Asians residing in Kirklees (West Yorkshire) were correlated with eight indices of deprivation. Spearman's correlation coefficient analysis suggested a strong relationship between notification rates and material deprivation (r = 0.58 [p value = 0.009 for a two-tailed test]). A similar association was also observed for unemployment (r = 0.51 [p value = 0.02 for a two-tailed test]), but not for overcrowding. This study suggests a link between TB and deprivation in ethnic minority groups in the UK.

England↗

Parts of visual form: psychophysical aspects.

Part-based representations allow for recognition that is robust in the presence of occlusion, movement, growth, and deletion of portions of an object, and play an important role in theories of object categorization and classification. A partitioning theory for visual form is proposed that is based on two types of parts: limb-based parts arise from a pair of negative curvature minima with evidence for "good continuation' of boundaries on one side; neck-based parts arise from narrowings in shape. The motivation for this model is computational requirements for recognition. The psychophysical relevance of this model is addressed by measuring intrasubject and intersubject consistency in partitioning tasks and comparing perceived and computed parts. A series of experiments were performed in which subjects were required to partition a variety of biological and nonsense two-dimensional shapes into perceived components. Specifically, it was examined (1) whether a subject determines components consistently across different trials of the same partitioning task, (2) whether there is evidence for consistency between subjects for the same partitioning task, and (3) how the perceived parts compare with limbs and necks resulting from the computational model. The results are interpreted as suggesting that there are high levels of both intrasubject and intersubject consistency and that a large majority of the perceived parts do in fact correspond to the parts computed on the basis of our model. The implications of our model are discussed in relation to previous experimental results. Intuitive observations concerning the relationship between parts of visual form and their function are then presented. Finally, a role is envisioned for parts in figure/ground segregation; the notion of a "parts receptive field' through which parts can serve as an intermediate representation between local image features, eg edges, and global object models, is suggested.

Adult↗