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K Skau

Publications and source records attributed to K Skau.

6 recordsLinked to original sources
PubMed1995

[Munchausen syndrome by proxy].

Munchausen Syndrome by Proxy (MSbP) in children is a form of child abuse in which a parent (usually the mother) or other care-taker feigns or fabricates disease symptoms in the child, often to the extent of causing serious physical harm, sometimes even resulting in death. Even if the child does not suffer actual physical harm, there is great danger that his or her social and mental development may be jeopardized. Health care personnel risk becoming party to the abuse through exposing the child to unnecessary medical procedures. A case of MSbP involving two siblings is presented in the article, together with a brief summary of current knowledge of the syndrome and measures for its management, emphasising the necessity of close cooperation between paediatrician, child psychiatrist and the social services.

Adult↗
PubMed1978

On the origin and fate of external acetylcholinesterase in peripheral nerve.

1. Rabbit peroneal nerves were exposed to echothiophate, a quaternary ammonium inhibitor of acetylcholinesterase (AChE), and 217-AO, its tertiary analogue, in an attempt to characterize the localization of the enzyme. Although 217-AO readily inhibited AChE throughout the nerves, echothiophate spared significant amounts unless the tissues had first been homogenized. Notably, doses of echothiophate inhibiting 84% of the total AChE inhibited only 30% of the rapidly transported enzyme, suggesting that AChE was distributed between compartments differing greatly in their accessibility to this drug. 2. Since charged molecules penetrate cells poorly, it seemed likely that the more accessible compartment of AChE was external, perhaps consisting mainly of enzyme incorporated into the outer surface of the axolemma. If one assumes that the inhibition of the transported enzyme accurately reflected the inhibition throughout the inaccessible compartment, it can be calculated that external AChE comprised about 80% of the total. 3. The quasi-irreversible inhibition of AChE by echothiophate was used to probe the dynamics of the external enzyme. Locally exposing nerves to this drug in vivo markedly inhibited the AChE in a short region, which subsequently recovered with a half-time of about 5 days. Recovery appeared to reflect delivery of new enzyme into the inhibited region rather than spontaneous reactivation or local synthesis of AChE. Surprisingly, the zone of inhibition neither broadened nor moved noticeably for at least 8 days. This implies that external AChE is largely fixed in place and must be renewed locally, presumably by incorporation of rapidly transported enzyme from the internal compartment.

Acetylcholinesterase↗