Reduced mortality rates in severe adult respiratory distress syndrome.
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Biomedical subjects
Publications and source records attributed to K Slama.
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General practitioners are in a position to influence the behaviour of the general population, notably as regards their smoking habits. This study aims to estimate the smoking habits of general practitioners in France, taken from a representative sample of 1012 general practitioners. The overall percentage of medical smokers rose in 1987 to 37%. The smoking habits varied according to age; thus if one considers current medical non-smokers, the oldest group are often ex-smokers, while the youngest are usually those who have never smoked. Compared to information obtained in 1980 from the medical population, one notes that there has been a fall in the level of doctors who smoke, whilst the proportion of doctors who have never smoked has risen considerably during the same period, particularly amongst young doctors.
The devastating long-term effects of tobacco smoking registered in the developed world and now imminent in the developing world must be responded to on national and international levels. In France, governmental tobacco control action began in 1976. Despite the high rates of premature mortality among men and women, legislative controls that were introduced were not enforced. Over the past decade, overall smoking prevalence has remained stable, reflecting growth in women's rates which compensates declines in men's rates. Comprehensive tobacco control measures should include prohibiting tobacco advertising, real tobacco retail price increases and regulations protecting non-smokers in public places. New legislation was voted in 1991 both in France and in the European Community. These measures, reinforced by a framework of continuing public education, may be an important step towards effective health promotion.
Surgery in patients treated with extracorporeal lung assist (ELA) carries a high risk of life threatening bleeding complications caused by the need for systemic anticoagulation. A case report describing a successful surgical intervention for the repair of a broncho-pleural leakage by thoracotomy during ELA is presented. A newly developed heparin coated extracorporeal system was used in a patient being treated for severe adult respiratory distress syndrome (ARDS) after left sided pneumectomy. The heparin coated system allowed discontinuation of systemic heparinization intraoperatively without coagulation complications related to the extracorporeal system. This procedure was followed by resolution of the ARDS.
Extracorporeal lung assist (ELA) has been recommended for the treatment of ARDS if conventional therapy fails. However, the need for nearly complete anticoagulation is a major risk factor for hemorrhagic complications. We describe our experience with 13 ARDS patients treated with ELA using heparin-coated systems (Carmeda). Maintaining partial thromboplastin time and activated clotting time within or close to the normal range, even major surgery (20 thoracotomies and 2 laparotomies) could be performed without undue bleeding complications related to anticoagulation during extracorporeal support. Eight of the 13 patients survived. The use of heparin-coated systems allows prolonged ELA with nearly physiological coagulation function, permitting major surgical intervention. It enhances the safety margin of extracorporeal gas exchange and may ultimately extend its indications.
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This paper summarizes the experience with ligation of persistent ductus arteriosus in prematures performed in the intensive care unit during the years 1986 to 1988. Records of 35 operated prematures on artificial ventilation were analyzed retrospectively. Management and organization of the operation are described. For comparison, records were analysed of 47 prematures, also artificially ventilated, who during the years 1978 to 1986 had to be transported to an operating theatre over a distance of 3 or 10 km for the ligation.
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OBJECTIVE: To evaluate a structured, behavioural change, smoking cessation intervention designed for use within general practice. DESIGN: Randomised controlled clinical trial. SETTING: General practices in Newcastle, Australia. PATIENTS: 311 Patients identified as smokers by a screening question were enrolled in the study. Of these, 101 were assigned to a structured behavioural change programme, 104 to a simple advice programme adapted from previous research, and 106 to a control group. No significant differences were found between groups for demographic and smoking related variables before the study. INTERVENTIONS: Patients in the simple advice group received a brief statement of advice from the general practitioner as well as three pamphlets; those in the structured intervention group were given strategies which included attitude and behavioural change programmes as well as techniques to aid compliance. The amount of smoking in all groups was assessed by self reports with validation by measurement of salivary cotinine concentrations. MAIN OUTCOME MEASURE: Significant increase in cessation rates. CONCLUSIONS: Significant differences between controls and the structured behavioural change group were found at the one month follow up, but only for self reported abstinence. The simple advice programme did not produce any significant differences over the control group. General practitioner evaluation of the structured programme highlighted difficulties in relation to the duration of the intervention. Overall the structured programme in its present form did not appear to be an effective programme for use within general practice.
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Derivatives of p-(1,5-dimethylhexyl)benzoic acid are juvenile hormone analogs with selective action on the hemipteran insects of the family Pyrrhocoridae. Their juvenile hormone activity is constant on five species of Dysdercus; it is about ten times lower on Pyrrhocoris, and no activity has been detected on hemipterans of some other families. Absence of profound species-specific variations in the activity suggests that the most active compounds of this type can be used as selective pesticides against all species of Dysdercus.