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Biomedical subjects

K Someya

Publications and source records attributed to K Someya.

At least 91 records · Page 5Linked to original sources
PubMed1980

[Evaluation of stat assay of serum digoxin concentration by radioimmunoassay and its application for digoxin regimen based in pharmacokinetics (author's transl)].

Serum digoxin concentration measured by stat RIA (phadebas digoxin RIA kit) correlated well with results obtained by complete assays. The results of stat assay can be reported within 1 hour, measuring one or more samples together with 2 standard samples in duplicates. Precise measurement can be expected with serum digoxin concentration over 0.5 ng/ml. The stat assay allows to apply the theory of pharmacokinetics for the estimation of digoxin concentration at steady states measuring minimum digoxin concentration (Cn(min)) on the 3rd to 6th day after the start of digoxin therapy. The estimated serum digoxin levels were well agreed with measured values with the difference ranging from 1.6 to 8.6% in CV. The method is useful for the planning and assessment of appropriate digoxin regimen.

Aged↗
PubMed1977

[In vivo X-ray fluorescent analysis of iodine concentration in the thyroid (author's transl)].

A simple apparatus was made for the X-ray fluorescent analysis of iodine concentration of the thyroid. The apparatus consists of 241Am gamma-ray source of 300mCi and pure Ge detector of 50mm2X5mm. Diverging collimator was designed to achieve a full view of the thyroid. The detectable concentration was 0.2mg iodine/g tissue assuming the coefficient of variance of 30% and the counting time of 5 minutes. Measurement was performed for autopsied 10 thyroids and the results were in good correlation with those by neutron activation analysis (r=0.93). Iodine concentration ranged 0.3-1.2mg/g (mean 0.6mg/g) and compared well with the data in literatures. This technique is useful for the in vivo measurement of thyroidal iodine content in patients.

Adult↗