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Biomedical subjects

K Stockamp

Publications and source records attributed to K Stockamp.

18 recordsLinked to original sources
PubMed1988

Treatment of advanced renal cell cancer with recombinant interferon alpha as a single agent and in combination with medroxyprogesterone acetate. A randomized multicenter trial.

The response rates in metastatic renal cell cancer (RCC) after chemotherapy, hormonal treatment, or immunotherapy rarely exceed 15%. Recently, interferon alpha (IFN alpha) was used for treatment of this disease in several studies which also demonstrated response rates of 15%. In order to test whether IFN therapy combined with hormones would result in higher response rates we compared single agent IFN therapy with a combined therapy of rIFN alpha 2C plus medroxyprogesterone acetate (MPA) in a randomized multicenter trial. The rIFN alpha 2C (2MU) was given s.c. 5 times per week for 8-12 weeks and subsequently once weekly until week 48. In the combined treatment, 750 mg MPA was given p.o. daily until week 48 in addition to the IFN as described. The overall response rate in 93 evaluable patients was 5.4% corresponding to 2 complete and 3 partial responses. Median survival was 7 months in both treatment groups. These data confirm the ineffectivity of low IFN doses for treatment of RCC. The low response rate is not increased by addition of MPA to IFN. The analysis of other IFN studies suggests that not only IFN doses but also IFN sources may influence response rates in metastatic RCC.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1976

Estrogenic sensitivity of alpha-receptors in the urethra musculature.

Estrogene has a tonicising effect upon urethra musculature. There is also the same demonstrable influence of alpha-receptor stimulating drugs upon the urethra pressure profile. After preliminary treatment with estrogene, there is a considerably stronger tonicising effect of alpha-stimulating drugs than without such a treatment. So the combination of estrogene and alpha-stimulating drugs seems a useful addition to the conservative treatment of stress incontinence.

Estrogens↗
PubMed1976

Conservative bladder treatment in myelodysplasia. Differentiation of patients by cystomanometry.

Urodynamic evaluation was performed in 75 patients with congenital neuropathic bladder. Concerning treatment the most important parameters were detrusor tone, detrusor activity and bladder outlet resistance. Based on these findings individual conservative therapy was applied. Reflux or dilatation of the upper urinary tract found in 26 children could be controlled by drugs or transurethral operations in 20, urinary diversion had to be done only 4 times. 26 children were selected for intensive treatment of incontinence; in about 50% satisfying urinary control was achieved. These results still need long-term observation. The main interest, however, was to postpone irreversible surgery and to gain time for possible better treatment in the future.

Adolescent↗
PubMed1976

[Pyelonephritis in patients with congenital malformations of the urinary tract after corrective operation and under antibiotic therapy (author's transl)].

398 (otherwise unselected) children with certain types of congenital urinary tract malformation were followed up for a period of not less than three years for evaluation of the infection rate after surgical correction (the latter performed in 1968 to 1972). During a six month course post op., all patients received appropriate antibacterial drugs, thereafter cessation of medical treatment depending upon normal findings in urinalysis. The over-all cure rate was 77% after six months, 85% after twelve months, 95% after two years and 97% after three years. No recurrence of urinary tract infection was observed three years after surgery of in frapelvic ureteral stenosis/hydronephrosis (n=86; Anderson-Hynes procedure) in 100%; of distal ureteral stenosis/megaureter (n=76; Politano-Leadbetter or occasionally Boari approach) in 92%; and of primary reflux (n=236; Lich-Grégoir technique) in 98%. The incidence of infectious relapse following any normal cytological and bacteriological control was 1% resp. 7% resp. 2%, with an average of 3% for all three groups.

Adolescent↗
PubMed1975

Treatment with phenoxybenzamine of upper urinary tract complications caused by intravesical obstruction.

Five children in whom reflux and progressive hydronephrosis persisted despite multiple surgical attempts or repair are described. In all cases cystomanometry displayed a marked elevation of the bladder outlet resistance combined with high intravesical pressure values. Therapy with phenoxybenzamine, an alpha-adrenergic blocker, was successful in all cases, restoring a free urine passage of the upper urinary tract and unimpaired voiding preventing urinary diversion which has been considered in some of these children. Although there were no signs of bladder neuropathy, a hyperfunction of the sympathetic innervation as acause for bladder complications is discussed.

Adolescent↗
PubMed1975

[Experimental studies in animals on the bladder function following sacral blockade with alkohol (author's transl)].

Caudal anesthesia was achieved with Xylocain-R in 13 dogs and with ethanol (99,2 percent) in 8 dogs. Urinary bladder function was studied before and after block. The results obtained are in agreement with the functional changes after rhizotomy of S1--S3: bladder capacity increases after cuadal block and pressures measured at equal volumes decrease. Urinary overflow was observed; 80 percent of the filling volume, however, remains within the bladder. An autonomous bladder contraction induced by smypathetic nerve activity could not be proven within our observation period of 7 days.

Anesthesia, Spinal↗