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Biomedical subjects

K Strasser

Publications and source records attributed to K Strasser.

At least 37 records · Page 2Linked to original sources
PubMed1990

Prognostic factors for local recurrence in patients with limited surgery and irradiation of breast cancer.

Between January 1975 and December 1984, 239 patients after breast conserving surgery were referred to the University Clinic for Radiotherapy and Radiobiology of Vienna. Of these patients 214 were available for analysis with regard to loco-regional control and cosmetic outcome. The breast received supervoltage irradiation from two tangential fields, in 82% with a tumor dose of 50 Gy and in 15% 50 to 60 Gy. In addition 70% of the patients received a boost dose with 7.5 to 15 MeV electrons to the tumor bed and the scar. The overall local failure rate was 10.2%. For patients with T1,2 and negative axillary nodes or less than four positive lymph nodes (N = 160) a recurrence rate of 7.1% was observed. Factors correlated to a higher local recurrence rate were in this retrospective study axillary status (greater than 3 positive lymph nodes), histopathologic grade (G III), absence of clear margin after surgery and absence of additional electron boost.

Adult↗
PubMed1990

[Sonography in breast diagnosis].

In a prospective study of 235 tissue masses verified histologically, we examined the diagnostic contribution of ultrasound in comparison to mammography. When the two methods were combined, 96.8% of all malignant neoplasms could be diagnosed correctly. Most (90.5%) were found by mammography alone and 4.8% were detectable by ultrasonography but not by mammography. Despite relatively good results in the evaluation of solid masses, it is not advisable to omit tissue examination. The superiority of ultrasound over mammography in the diagnosis of cystic lesions could lead to a significant reduction in needle aspirations and biopsies.

Adenofibroma↗
PubMed1988

[Neurologic symptoms in inhalation poisoning with metallic mercury].

Nineteen caisson workers had been exposed to metallic mercury vapours while digging tubes underneath the first district of Vienna (exposure between 470 and 2440 min; mean 1621 min). The blood mercury values on admission were between 29 and 166 micrograms/l (mean 75 +/- 34 micrograms/l). The main findings reported are clinical neurologic symptoms, psychic complaints, neurographic results and autonomic parameters (cardiovascular reflexes): 47% complained of headache and tiredness, 37% showed tremor and suffered from sleep disturbances, 26% showed hypersalivation, 16% changes in handwriting, and 11% slight dysarthria. The cardiovascular reflexes (autonomic parameters) were abnormal in 7 of 12 patients. On neurography the distal latency (median nerve) was pathologic in 47%, the distal latency (peroneal nerve) was pathologic in 26%, the antidromic sensory nerve conduction velocity (median nerve) was abnormal in 10%, the motor nerve conduction velocity, compound amplitude and vibratory threshold were normal.

Adult↗
PubMed1985

[10 years' experience with the concept of breast-saving therapy in the treatment of breast cancer].

A therapeutic concept dependent on staging of breast carcinoma is presented. In 1974 we started at the 2. Surgical University Clinic Vienna to use the non ablative treatment in patients with breast cancer smaller than 2 cm. Up to 1984 102 patients underwent quadrantectomy axillary dissection, and radiotherapy. With equal therapeutic results the smaller and cosmetically preferable surgical intervention is recommended.

Austria↗
PubMed1984

[Late results following carotid endarterectomy].

186 carotid endarterectomies (142 patients) were performed under regional anaesthesia between 1976 and 1983: 32% in asymptomatic stage, 36% in TIA, 4% in frank stroke, 28% in completed stroke. Postoperative mortality was 3.8%, neurologic deficit following endarterectomy 4% (2% transient, 2% permanent). Patients were followed-up six months to seven years after the operation: The incidence of late stroke amounted to 7% (11% in TIA-patients, 5% in patients with completed stroke before endarterectomy). 24% of the operated patients died during the follow-up period, 46% because of myocardial infarction or heart failure, 14% because of stroke. Recurrent stenosis occurred in 6% (indirect Doppler-sonogramm), two patients (3%) with symptomatic recurrent stenosis underwent reoperation.

Arteriosclerosis↗
PubMed1981

[Plasma level of etidocaine within the first two hours after axillary plexus block in healthy adults and patients with renal insufficiency (author's transl)].

The plasma level of etidocaine was studied within the first two hours of axillary block in 7 patients with renal insufficiency and 7 healthy adults. After 15-20 min the maximum of plasma concentration was found in the group with renal failure and after 30-45 min in the healthy adults. 30 min after the block the plasma level was 1,26 +/- 0,62 mug/ml in the ill patients and only 0,73 +/- 0,31 in the normal group. Using a mathematical model the ratio of permeation into the blood is significantly higher in the group with renal failure than in the healthy adults. The main reason for these results seems to be the acidosis, which is often combined with renal insufficiency. The meaning of these results for regional anaesthesia in patients like these is discussed.

Acetanilides↗
PubMed1980

Effects of cimetidine and pirenzepine on peroperative electrical vagal stimulation of gastric acid secretion.

Atropine and an eightfold greater amount of pirenzepine inhibit pentagastrin-stimulated secretion to nearly the same extent (70-75%). Neither drug influences acid concentrations markedly (18%). Atropine and pirenzepine decrease the potassium concentration of gastric juice. By increasing electrical vagal stimulation the inhibitory effect of cimetidine decreases. In contrast, inhibition of vagally stimulated secretion by pirenzepine or by atropine averages 45%, when vagally stimulated secretion amounts to more than 50% of the pentagastrin-stimulated secretion. Thus pirenzepine inhibits gastric secretion similarly to atropine. These results support the hypothesis of a histamine and a cholinergic receptor.

Adult↗
PubMed1980

[Tachyphylaxis in continuous epidural anaesthesia with bupivacaine 0.125% and 0.25% (author's transl)].

Based on the results in 105 patients under continual thoracic epidural analgesia differences in the dose response relationship of bolusinjections are found. While under bupivacaine 0.25% a decrease of the effectivity of additional bolusinjections can be stated, the dose response relationship does not change under bupivacaine 0.125%. Moreover the effectivity of bupivacaine 0.25% increases after an interruption of the local anaesthetic infusion. The pH-value of bupivacaine 0.25% was 6.0 and that of bupivacaine 0.125% 6.3. Even so the differences of the pH-values between the two solutions are rather small, a possible key to the problem of the dose response relationship, concerning tachyphylaxis, can be suggested. But further investigations have to show, whether the use of local anaesthetic solutions, being stable at pH-values of 7 to 8, makes the continuous epidural analgesia easier to handle for postoperative pain relief.

Aged↗
PubMed1980

[Incidence of persistent occipitoposterior positions with or without epidural anaesthesia (author's transl)].

The incidence of persistent occipitoposterior positions (POP-positions) during the period from 1969-76 in 7,469 vaginal deliveries was studied with respect to the influence of epidural anaesthesia (EA), parity and age. The EA-group consisting of 1,553 deliveries showed a higher number of POP-positions (4.3%) than in the two control-groups without EA (2.8%, 2.0%). The increase in the EA-group depended to some extent on the higher proportion of primiparae and thus younger parturients in this group. In addition a multiway frequency table analysis proved a specific interrelation between the increased frequency of POP-positions and the application of EA (p < 0.01). A selection of POP-positions for inclusion in the group of deliveries with EA could be excluded indirectly. The results are compared to those of other authors. Inquiring into the reasons for the relatively small increase of POP-positions in our EA-group discussion is made upon the advantages of a low-dose catheter EA.

Adolescent↗
PubMed1977

Relation of transcutaneous to arterial pO2 in hypoxaemia, normoxaemia and hyperoxaemia. Investigations in adults with normal circulation and in patients with circulatory insufficiency.

The transcutaneous oxygen tension was monitored continuously by a heated cutaneous polarographic electrode in 7 adult intensive care patients, 12 patients without circulatory insufficiency, and 5 healthy volunteers, Arterial pO2 values were varied from hypoxaemia to normoxaemia and hyperoxaemia by variations of the inspired oxygen concentration. In normal volunteers and in patients without circulatory failure, transcutaneous pO2 indicated on an average about 81-92% of the arterial pO2 in normoxaemia and hyperoxaemia with a correlation coefficient of 0.97. In hypoxaemia there was an over-proportional decrease of the transcutaneous pO2 to a mean value of 44% fo the arterial pO2. In one case the transcutaneous pO2 reproducibly dropped to zero at paO2 values of 41 respectively 38 mm Hg (5.5 respectively 5.1 kPa). In intensive care patients the transcutaneous pO2 values were considerably lower than the paO2 values. There was no constant transcutaneous to arterial pO2 ration in most of the intensive care patients at different pO2 levels. In adults without disturbance of peripheral perfusion paO2 can be predicted with satisfactory accuracy from transcutaneous pO2 values in normoxaemia and in hyperoxaemia. In hypoxaemia and in circulatory insufficiency, the transcutaneous pO2 is only an indicator of the trend of the arterial pO2. Under these conditions it does not allow a quantitative estimate of paO2 changes.

Adult↗
PubMed1977

[Placental transfer of carticaine (Ultracain) a new local anesthetic agent (author's transl)].

Serum levels of carticaine were measured in 9 parturient women after peridural anesthesia as well as in the newborns. The neonatal serum level of carticaine amounted to 32 +/- 7% of the maternal (ratio = 0,32). This proportion is compared to those given in the literature for the local anesthetics Lidocaine (0,52-0,58), Mepivacaine (0,64) and Bupivacaine (0,23-0,26).

Adolescent↗