MRI and ultrasonography in staging prostate cancer.
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Humans↗
Biomedical subjects
K Streule
Publications and source records attributed to K Streule.
99Tcm-labelled HSA-nanocolloid versus 111In oxine-labelled granulocytes in detecting skeletal septic process.
Fifty-seven investigations of the skeletal system were performed on 54 patients, using a 99Tcm-labelled nanometer-sized HSA colloid in a crossover comparison with 111In oxine-labelled granulocytes for the detection of sites of infection. The findings were in agreement in 55 out of 57 investigations (96.5%). Based on 44 studies in which a final clinical diagnosis was obtained, both methods were found to display the same specificity (93%), whilst the sensitivity of 99Tcm nanocolloid scintigraphy (87%) was slightly higher than that obtained with 111In leucocyte scintigraphy (81%). In our opinion, 99Tcm nanocolloid is easier to use and the total duration of the investigation is considerably shorter. The use of 99Tcm is scintigraphically more advantageous and, with the dosage required, the absorbed radiation dose to the red bone marrow is three times lower than with 111In granulocytes. For the detection and therapy monitoring of osteomyelitis, as well as for the investigation of arthroplasties suspected of infective loosening, we consider scintigraphy with 99Tcm nanocolloid to be equivalent to leucocyte scintigraphy. Identical findings were obtained with both tracers in suspected spondylodiscitis.
Female↗
[Differential diagnosis of pneumonia and pulmonary infarct based on lung scintigraphy].
The etiology of radiologic signs of circumscript parenchymatous lesions is multivarious. In some instances infarction of the lung has to be distinguished from pneumonia. The differential diagnosis has important therapeutic consequences for the patient. An important criterion for primary pneumonic infiltration is Xe-trapping within the area lacking perfusion, which can only be demonstrated by perfusion scintigraphy with Xe-133-NaCl. However, infarction of the lung lacks this pathologic feature. Pathophysiologically the various changes may occur as the result of obstruction of the vessel i.e. due to alveolar hypoxia and embolism. In order to improve the diagnostic methods a combination of perfusion scintigraphy using Xe-133-NaCl and Tc-99-macroaggregate and ventilation scintigraphy with Xe-127 was employed. We retrospectively evaluated 20 patients with the nuclear medical diagnosis of either pneumonia (n = 10) or infarction of the lung (n = 10). The following criteria were adopted: history, risk factors, X-ray of the chest, blood chemistry, ECG, phlebography, pulmonary angiography and histopathological diagnosis, as well as the course of the disease. According to our results the specificity of the scintigraphic diagnosis of pneumonia and infarction of the lung was 90%. However these results will have to be verified in a prospective study using pulmonary angiography as the reference method.
Aged↗
Scintigraphy of inflammation with nanometer-sized colloidal tracers.
The biodistribution of a nanometer-sized colloid was tested in three groups of rats, one with a turpentine-induced abscess and one with a histamine-induced oedema in the musculature of a hind leg. The third group served as a control. A 99Tcm-labelled colloid with a mean particle size of 30 nm was administered to each group intravenously. The biodistribution of the tracer, studied 1 h after injection, demonstrated that the colloid accumulated to a very limited extent in oedematous tissue, whereas the uptake in inflamed muscle was high. The colloid was subsequently administered to patients with arthritis, osteitis and osteomyelitis. All sites of inflammation accumulated the radiopharmaceutical and could be visualized scintigraphically 45 min after its administration. The results were in agreement with 67Ga-citrate or 111In-leukocyte scintigraphy, and/or other diagnostic modalities. Hyperaemia alone was not sufficient to cause uptake. We conclude that the mechanism of uptake is regional spilling of the tracer into the extravascular space through gaps in the damaged basement membrane, and that nanometer-sized 99Tcm-labelled colloid may constitute a convenient radiopharmaceutical for detecting inflammation in the extremities.
Animals↗
"Brunneroma": hamartoma or tumor?
Clinically relevant "tumors" of duodenal glands (Brunner's glands) are uncommon. We present a patient suffering from an exceptionally large tumor of the pars descendens of the duodenum. The tumor remained undetected at endoscopy and is of interest because of its localization, size and its presumable production of urogastrone (human epidermal growth factor). "Brunneromas" are probably hamartomas rather than true neoplasias.
Adult↗