PubMed Health⌕ Search

Biomedical subjects

K Sumitomo

Publications and source records attributed to K Sumitomo.

31 records · Page 2Linked to original sources
PubMed1986

The use of prostaglandin F2 alpha and scopolamine-N-butylbromide in anorectal manometric diagnosis.

To improve the accuracy of diagnosis of Hirschsprung's disease by means of anorectal manometry, prostaglandin F2 alpha (PGF2 alpha) and scopolamine-N-butylbromide (Buscopan) were used. Normal rectoanal reflex was facilitated by PGF2 alpha in 6 out of 7 children and was abolished or markedly inhibited in 12 out of 13, when Buscopan was given. Obscure rectoanal reflexes in 7 normal neonates were clarified following the administration of PGF2 alpha. On the other hand, atypical rectoanal reflexes observed in 7 children with Hirschsprung's disease were unchanged with either PGF2 alpha or Buscopan. Therefore the use of PGF2 alpha or Buscopan facilitates the manometric diagnosis of Hirschsprung's disease. In 9 postoperative children with Hirschsprung's disease the reflexes were obscure. Five of these 9 reflexes became clear after the administration of PGF2 alpha and 4 remained unchanged. As the normal rectoanal reflex was enhanced by PGF2 alpha, the obscure reflex seen in the postoperative period can be positive or negative, using PGF2 alpha.

Adolescent↗
PubMed1984

Assessment of bowel control with anorectal manometry after surgery for anorectal malformation.

Bowel function after surgery for anorectal malformation was assessed by Kelly's score in 101 children over 3 years of age. Seventy-two were examined using anorectal manometry. In the "good" group, resting pressure of the anal canal was as high as in the normal children, and the frequency of contraction waves in the anal canal was the same as in the normal children. Recto-anal reflex was recognized in about three fourths of the "good" group. On the other hand, in the "poor" group resting pressure was low, in only one were contraction waves evident and in none was there a recto-anal reflex. The findings of the anorectal manometry placed the "fair" group between the "good" and the "poor" groups. The clear contraction waves of the anal canal or the clear recto-anal reflex related to a resting pressure in the anal canal of over 20 cmH2O. This high pressure in the anal canal is important for good and continence, and depends on a precise pull-through of the rectum into the puborectalis muscle.

Anal Canal↗
PubMed1984

Induction of the rectoanal reflex by electric stimulation. A diagnostic aid for Hirschsprung's disease.

We induced the rectoanal reflex electrically in three groups of children, following rectal dilatation with a balloon. In normal children, and in children with constipation or ileus due to causes other than Hirschsprung's disease, the rectoanal reflex was induced by electric stimulation as well as by dilatation of the rectum with a balloon. In children with Hirschsprung's disease, however, no typical reflex was obtained by either of these stimuli. Since electric stimulation does not dilate the rectum, passive dilatation of the anus or shift of the probe along with balloon expansion does not take place, so no false-positive reflex is elicited. Electric current, moreover, is capable of providing a constant quantifiable stimulus. We have demonstrated the induction of the rectoanal reflex by electric stimulation alone; distention of the circular muscle of the rectum does not appear necessary for the induction of this reflex.

Anal Canal↗
PubMed1977

Ultrastructure of platelets of the vitamin E-deficient rats.

The platelets of vitamin E-deficient rats show a remarkable structural destruction of the mitochondria, mainly in the membrane, and a considerable decrease in the number of mitochondria. In addition, significant decreases are manifested in the numbers of microtubules, alpha-granulomers, dense bodies and glycogen particles, accompanied by remarkable vacuole formation. The longer the vitamin E-deficient period, the more remarkable the changes are. Rats deficient in vitamin E for 58 weeks showed the highest degenerative changes in the platelets.

Animals↗