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Biomedical subjects

K Sutter

Publications and source records attributed to K Sutter.

10 recordsLinked to original sources
PubMed2006

[High blood pressure and alcohol consumption].

The possible effects of individual alcoholic beverages on blood pressure continue to arouse interest. There is a positive relationship between alcohol intake and blood pressure. The nature of this relationship still remains unresolved. Authors led studies where different patterns of drinking were assessed. First, different mechanisms are involved for generating hypertension when alcohol drinking. Vasoconstriction effects and modification of smooth muscles are well established factors of alcohol-induced hypertension. Calcium movements are also involved. Men and women are affected by hypertensive effects of excessive alcohol consumption. Drinking alcohol during meals is a probable protective factor of developing hypertension. Reducing alcohol consumption provokes a significant diminution of hypertension.

Alcohol Drinking↗
PubMed2005

[The use of psychotropic drugs in alcoholism].

Comorbid psychiatric disorders occur frequently in patients with alcohol dependence. Psychotropic medications as antidepressants, benzodiazepines, antipsychotic or hypnotic medications are sometimes useful with alcoholic patients. Their prescription has to be cautious, well-assessed and time-framed. Globally, antidepressants have very little effect on alcohol outcomes meanwhile benzodiazepines are the drug of choice for alcohol withdrawal. But their use has to be very careful because of their addictive potential. Antipsychotic medications have no real indications. Considering the risk of relapse related to insomnia, sedative medications might be useful after detoxification to prevent relapse.

Alcoholism↗
PubMed2005

The use of the aquatic moss Fontinalis antipyretica L. ex Hedw. as a bioindicator for heavy metals: 3. Cd2+ accumulation capacities and biochemical stress response of two Fontinalis species.

We studied heavy metal stress responses of two Fontinalis species, F. antipyretica and F. dalecarlica, collected from two habitats in Germany and Canada. The capacities of the two species for extracellular adsorption (biosorption) and intracellular uptake (bioaccumulation) of Cadmium (Cd2+) were investigated in the laboratory. Time-dependent Cd2+ adsorption by cell wall and intracellular uptake differed significantly between the two species. These differences were related to the number of Cd2+ binding sites, resulting from differences in leaflet surface and cell wall composition. Glutathione (GSH) levels in response to Cd2+ exposure were monitored over a 10-day period. GSH synthesis differed significantly between the two species. Both Fontinalis species appear to be suitable for heavy metal biomonitoring in aquatic habitats.

Adsorption↗
PubMed1994

[Ethanol content of Kefir water].

The question of the influence of kefir on blood-alcohol-level has been asked in a legal proceeding. The questioned recipe consisted of 21 water, 6 soup-spoons of kefir granules (about 120 g), 150 g sugar, 2 figs and one lemon. The consumption took place after two days of fermentation. Experimentally we found, that one liter of this kefir product may contain up to 38 g/l ethanol after 7 to 10 days. On the second day we measured up to 16 g/l ethanol. Our results may be import for expert appraisements concerning unability of driving.

Alcohol Drinking↗
PubMed1993

[Iatrogenic methadone poisoning].

Two young drug addicts received in the course of their treatment a 10-fold overdose of methadone by error. One person died, the other was severely intoxicated but survived. The cause for the mistreatment was the unawareness of the medical personnel, that did not realize the change in concentration of the methadone stock solution from 0.1% to 1.0%, provided by the pharmacy. To prevent such mistakes in the future a change in labelling of the bottle giving directions for correct dosing is suggested.

Adult↗
PubMed1991

Expression of recombinant TGF-beta 2(442) precursor and detection in BSC-40 cells.

Analysis of cDNA clones encoding transforming growth factor (TGF)-beta 2 predicts two different precursor proteins derived by alternative mRNA splicing; a 414 amino acid precursor [TGF-beta 2(414)] and a 442 amino acid precursor [TGF-beta 2(442)]. The two proteins differ by a 28 amino acid insertion within the pro-region of TGF-beta 2(442). In order to characterize the TGF-beta 2-related proteins encoded by the TGF-beta 2(442) cDNA and determine whether it could, in fact, direct the synthesis of active growth factor, we have expressed this gene in Chinese hamster ovary (CHO) cells and, after amplification with methotrexate, obtained stable clones secreting TGF-beta 2(442). The TGF-beta 2 secreted by these cells was latent as acidification was necessary to detect optimal biological activity. In addition to mature TGF-beta 2, high molecular weight pro-region containing proteins were also secreted as analyzed by immunoblotting using site-specific anti-peptide antibodies. These proteins migrated differently than those secreted by CHO cells transfected with cDNA encoding TGF-beta 2(414), indicating that structural differences exist between the two complexes. An anti-peptide antiserum was produced in rabbits against the 28 amino acid insert region of TGF-beta 2(442). This sera was then used to detect the presence of TGF-beta 2(442) in serum-free media conditioned by BSC-40 cells. Since the TGF-beta 2(442) precursor is produced and secreted by a non-recombinant cell line, this suggests that it may play a physiological role in regulating the activity of TGF-beta 2.

Animals↗
PubMedDate not supplied

Reliability of head circumference measurements in preterm infants.

PURPOSE: To describe and compare the intra- and interexaminer reliability of head circumference measurements obtained with paper and cloth tape measures. METHOD: Two experienced neonatal nurses each obtained head circumference measurements using both paper and cloth tape measures twice each, from 49 clinically stable, preterm infants. The nurses were blind to their own and to each other's measurements. The order in which the measurements were obtained was randomized. The differences within and between examiners for cloth and paper tape measurements were described using mean absolute differences, standard deviation of net differences, technical error of measurement, minimal and maximal differences, percentage of differences 0.25 and 0.5 cm, and percentage of error. RESULTS: Wilcoxon matched-pairs, signed-ranks tests demonstrated significantly greater intraexaminer reliability for measurements obtained with the paper tape for both of the nurses. Wilcoxon matched-pairs, signed-ranks tests also demonstrated significantly greater interexaminer reliability for measurements obtained with the paper tape for both the first and second measurement sets. CONCLUSIONS: Intra- and interexaminer differences were consistently smaller when the examiners used paper tape measures.

Cephalometry↗
PubMedDate not supplied

[Methane in cadaver blood--homicide by natural gas or postmortem formation?].

A man had a quarrel with his wife. Suddenly he collapsed and became cyanotic. The woman supposed him to be dead. Because she was afraid of familiar requital, she opened the gas-cock of the cooking-range to pretend a suicide; methane emitted. The autopsy revealed a fresh cardiac infarction. Postmortem chemical analysis established methane in the blood. The question was, whether the methane had any importance for the death. By experimental inhalation of a methane-air-mixture (3%) we could expose, that the methane concentration in postmortem blood didn't have any relevance for the death.

Adult↗