Biomedical subjects

K Svanes

Publications and source records attributed to K Svanes.

111 records · Page 7Linked to original sources

PubMedDate not supplied

The role of blood flow in gastric mucosal defence, damage and healing.

Blood flow plays an important role in protection of normal gastric mucosa and in the protection and healing of damaged mucosa. Blood flow contributes to protection by supplying the mucosa with oxygen and HCO3-, and by removing H+ and toxic agents diffusing from the lumen into the mucosa. Low mucosal blood flow predisposes to injury, whereas high blood flow protects against injurious agents. Superficial mucosal damage is followed by increased blood flow which supports the healing process and prevents superficial lesions from developing into deep ones. The hypermic response increases the supply of HCO3- to the mucosa and increases the resistance of the injured mucosa against back diffusing H+ and aggressive drugs such as ethanol (adaptive protection). Mucosal ischemia contributes to gastric ulceration in various clinical conditions such as hemorrhagic shock, stress, aorta aneurysm and after proximal gastric vagotomy. Blood vessels are damaged in gastric ulcers. During ulcer healing blood flow returns to normal. Stimulated or inhibited angiogenesis in the granulation tissue effects the healing of a gastric ulcer.

Animals↗

PubMedDate not supplied

Hemodynamic changes associated with strangulation obstruction in cats.

While changes in blood flow associated with simple intestinal obstruction have been studied extensively, little is known about blood flow changes associated with strangulation obstruction. Closed loop strangulation was produced in anesthetized cats by means of a baby pressure gasket. Intestinal blood flow was measured by transit time flowmetry. Blood pressure was measured in a carotid artery and in veins of a closed loop of small intestine. The gasket pressure was increased stepwise in 10 mm Hg increments after which the intestinal venous pressure was kept constant at 50 mm Hg for 5 h. Increasing gasket pressure was followed by a corresponding increase in venous pressure in the closed bowel loop. Blood flow in the closed loop decreased with increasing venous pressure and was closely related to the arteriovenous perfusion pressure under stepwise increase of the gasket pressure and during prolonged periods with increased venous pressure. At constant elevated venous pressure the intestinal blood flow was determined by the arterial pressure. The vascular resistance in the closed loop increased exponentially with increasing venous pressure and especially at very low blood flow. In conclusion, we have found that strangulation obstruction is associated with increased venous pressure in the closed loop which contributes to maintaining intestinal blood flow during the obstruction.

Animals↗

PubMedDate not supplied

Long term results after Nissen fundoplication and Belsey Mark IV operation in patients with reflux oesophagitis and stricture.

This retrospective study was undertaken to compare long term results of Nissen fundoplication and the Belsey Mark IV repair in patients with reflux oesophagitis and stricture between 1972 and 1987. 105 patients were operated on for reflux oesophagitis, and 43 of the patients had stricture. There was one postoperative death (after a Belsey Mark IV repair). The cumulative recurrence rate after the Nissen operation was 9%, all recurrences of oesophagitis occurring within the first two years. The cumulative recurrence after the Belsey repair was 37%. Only 15 of 32 patients treated with Nissen fundoplication for stricture needed dilatation after operation, and then only during the first two years. "Gas-bloat" occurred in 18% of the patients treated with Nissen fundoplication. We conclude that the Nissen fundoplication is a good operation for patients with severe reflux oesophagitis and for those with peptic strictures of the oesophagus. The Belsey Mark IV repair, however, cannot be recommended for patients with strictures.

Adult↗