Biomedical subjects

K T Tzen

Publications and source records attributed to K T Tzen.

3 recordsLinked to original sources

PubMed1991

Hepatitis A virus infection in Taipei City in 1989.

To evaluate the current status of hepatitis A virus (HAV) infection, a seroepidemiologic study to detect the prevalence of antibodies against HAV (anti-HAV) has conducted in Taipei City, from March to July, 1989. Serum specimens were collected from 602 male and 503 female apparently healthy children age 12 and under. The prevalence rate of anti-HAV was 27.5% in infants, and decreased to nearly 0% in preschool and early school children up to 10 years old. Compared to a previous study in the same area of Taipei in 1984, our study indicated a further and significant reduction in the prevalence of anti-HAV in almost every age group from 2 to 14 years of age. There was an average of a 5-year prevalence shift. These data suggest that there has been no significant endemic of HAV infection from 1984 to 1989. The antibody prevalence change in the different age groups represents an ongoing trend of HAV seroepidemiology in Taiwan where HAV infection is becoming rare. The age of primary infection in children has been extended to an older age group. The rarity of HAV infection in Taiwan has created a large and growing population of young adults susceptible to hepatitis A virus infection. The effective prevention of hepatitis A virus infection will become a major public health concern.

Child↗

PubMedDate not supplied

Mastitis neonatorum.

Eleven cases of neonatal mastitis diagnosed at National Taipei College of Nursing Health Center, since 1983, have been reviewed by chart retrospectively. All 11 cases occurred in full-term infants 1-4 weeks postnatally. Female predominated with male: female ratio of 1: 1.75. The mastitis of these cases were confined to unilateral side and did not spread systemically. Gram stain smear of the purulent material got from aspiration, incision or spontaneous rupture of abscess were attempted in ten cases and Gram positive cocci were observed in nine of whom pus culture yield staphylococcus aureus later in eight. We feel Gram stain is one of the rapid and useful diagnostic method. Treatment was given by appropriate antibiotics parenterally followed by surgical incision or drainage when fluctuation was present. The prognosis of neonatal mastitis is excellent. In general, these our clinical observation are similar to those described in the literatures since 1950s.

Female↗

PubMedDate not supplied

Prognosis of coronary arterial lesions in Kawasaki disease treated without intravenous immunoglobulin.

From 1981 to 1989, a total of 86 consecutive patients with definite Kawasaki disease who received aspirin but not intravenous immunoglobulin (IVIG) therapy during the acute stage were studied. Thirty-eight of them (44%) had coronary arterial lesion (CAL) on initial two dimensional echocardiograms. Of them, 21 (56%) had ectatic coronary changes, 13 (34%) had small to large coronary aneurysms (diameter < or = 8 mm) and 4 (10%), giant coronary aneurysms (diameter > 8 mm). Patients with CAL had, in the acute stage, a longer duration of fever (p < 0.01), higher maximum platelet counts (p < 0.05) and a higher one-hour erythrocyte sedimentation rate (< 0.01) than those without. Males were associated with a higher incidence of aneurysmal dilatation of the CAL. By actuarial event-free analysis, more than half of the ectatic coronary lesions regressed within two months of onset, and 86% became normal on echocardiograms within a two-year follow-up period. Ectatic lesions had a significantly higher chance of regression than aneurysmal lesions (p < 0.01). Furthermore, none of the giant aneurysms regressed (p < 0.05, as compared with those coronary aneurysms smaller than 8 mm in diameter). It was concluded that coronary arterial lesions occurred in a substantial number of Chinese children with Kawasaki disease who received only aspirin therapy. Regression of the lesions was related to their size and morphology.

Adolescent↗