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Biomedical subjects

K Talle

Publications and source records attributed to K Talle.

At least 19 recordsLinked to original sources
PubMed1989

Early liver metastases in patients with medullary carcinoma of the thyroid gland.

In 13 patients who had been thyroidectomized for medullary carcinoma (MCT), basal and pentagastrin-stimulated immunoreactive calcitonin (iCT) concentrations were measured in a peripheral vein and concomitantly in hepatic veins as well as in the superior and inferior caval veins. The basal concentrations of iCT in serum from the antecubital vein ranged from normal values (less than 0.50 micrograms/1) to grossly elevated (greater than 100 micrograms/1). Intravenous pentagastrin injections (0.5 micrograms/kg) stimulated transiently calcitonin secretion in all patients and peak concentrations occurred in peripheral venous blood and in the inferior caval vein after 3 to 5 minutes. In all patients peak iCT values in the hepatic vein occurred at 1 to 2 minutes and were much higher than in samples taken from other veins. Only three patients showed metastases to liver as judged by conventional clinical and laboratory examinations. Two patients with nonthyroid, malignant disease did not show an increase in serum iCT concentration of hepatic veins. The authors conclude that MCT may spread early to the liver. The presence of liver metastases is an important prognostic factor in patient evaluation and can be demonstrated by measuring iCT in hepatic veins before and during pentagastrin stimulation.

Adult↗
PubMed1985

Prognostic factors in liposarcoma.

In a series of 99 liposarcomas, the prognostic impact of the various diagnostic and therapeutic factors was analyzed. The analysis indicated that the tumor size, histologic subtype, and x-ray density are important prognostic factors. The prognosis is also influenced by operability and treatment modalities employed. Treatment strategy should be radical, irrespective of the actual prognostic factors.

Age Factors↗
PubMed1979

Effect of irradiation on the feto-placental tissues.

Seven pregnant patients with genital carcinoma were treated with high voltage irradiation in combination with operation. Five patients aborted spontaneously after a dose of 30 to 34 Gy. Two were operated within 2 weeks after completed irradiation. Angiography, microscopy and hormone analyses indicate that damage of the fetal central nervous system and not placental insufficiency is responsible for the intrauterine fetal death.

Abortion, Therapeutic↗
PubMed1977

Combination chemotherapy of germ cell tumors of the testis with vincristine, adriamycin, cyclophosphamide, actinomycin D and medroxyprogesterone acetate.

Forty-three patients with disseminated germ cell cancer were treated with a combination of vincristine, Adriamycin, cyclophosphamide, actinomycin-D, and medroxyprogesterone acetate. All the 43 patients were considered evaluable for response. Thirty-one patients (72%) achieved a complete or partial remission and 14 (32.5%) achieved a complete remission. The patients who attained an objective response obtained a significant prolongation of life compared with the nonresponders (median survival 55 vs. 23 weeks). Responses were seen in all histologic categories and most frequently in patients with metastases confined to the lungs. The major side effects were leukopenia and stomatitis. There were no deaths related to toxicity of the chemotherapy.

Adolescent↗
PubMedDate not supplied

Increased detectability of liver metastases by the use of contrast enhancement in computed tomography. A comparison between the precontrast, the immediate postcontrast and the one hour postcontrast scan.

The precontrast, immediate postcontrast and the one hour postcontrast CT scans were analysed in search for liver metastases in 75 patients with malignant disease. The use of high dose intravenous contrast medium (42 g I) increased the number of hepatic metastases detected. The one hour postcontrast scan revealed a few more lesions than the immediate postcontrast scan. Further investigations on this subject are necessary before any definite conclusions can be made as our series of patients is small. In routine CT the most practical procedure in search for liver metastases is: 1) Scanning of the liver without contrast medium. 2) Incremental dynamic scanning during and immediately following injection of contrast medium. 3) If there is still uncertainty: Scanning at a later time, for example at one hour after injection of contrast medium.

Contrast Media↗