Effect of dithiocarbamate-type chemicals on the nervous system of rats.
Neurotoxic effect of some dithiocarbamate- and thiuram-disulphide-type chemicals as well as CS2 were examined on rat brain and behaviour. A significant reduction of the orientation hypermotility and at the same time a depression of the subcortical EEG activity were observed. The biochemical assay showed a decreased re-formation of norepinephrine. It is suggested that the inhibition of DBH enzyme may be involved in the delayed psychosedative effect, but not in the short-term electrophysiological changes.
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