[Important aspects of the epidemiology of aspergillosis].
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Aspergillosis↗
Biomedical subjects
K Tintelnot
Publications and source records attributed to K Tintelnot.
Disseminated Penicillium marneffei infection in an African AIDS patient.
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AIDS-Related Opportunistic Infections↗
Cerebral phaeohyphomycosis caused by an Exophiala species.
A 45-year-old woman was found to have cerebral phaeohyphomycosis caused by an Exophiala species. The portal of entry of the fungus remained unknown. Despite surgery and antimycotic therapy the patient died from circulation failure. The fungus is compared to several related Exophiala species.
Brain↗
Disseminated mycosis due to Scedosporium prolificans in an AIDS patient with Burkitt lymphoma.
A case of fatal disseminated infection caused by the dematiaceous hyphomycete Scedosporium prolificans diagnosed post mortem is reported in a 60-year-old male patient with acquired immunodeficiency syndrome who additionally suffered from Burkitt's lymphoma. The patient was significantly granulocytopenic following aggressive chemotherapy and irradiation. He developed dyspnoea at rest and chest pain despite a normal chest radiograph. Fluconazole treatment was carried out empirically because no sign of a fungal infection was detected ante mortem, either by mycological cultivation or by serological investigation. First post-mortem examination revealed a disseminated fungal infection involving the central nervous system. Scedosporium prolificans was cultured from the kidney, spleen and myocardium. In vitro, the fungal isolate was found to be highly resistant to all available systemic antimycotics.
AIDS-Related Opportunistic Infections↗
Port-a-cath-related Fusarium oxysporum infection in an HIV-infected patient: treatment with liposomal amphotericin B.
The first case of Port-a-cath-related disseminated fusariosis in an HIV-infected patient is presented. Antifungal treatment with liposomal amphotericin B (AmBisome) in a dose of 2 mg kg-1 day-1 for 14 days was successful.
AIDS-Related Opportunistic Infections↗
Disseminated Neocosmospora vasinfecta infection in a patient with acute nonlymphocytic leukemia.
We report Neocosmospora vasinfecta infection following chemotherapy for acute nonlymphocytic leukemia. N. vasinfecta, a plant pathogen, was identified by culture and genetic sequencing. Susceptibility testing revealed in vitro resistance for common antifungals.
Adult↗
Systemic mycosis caused by a new Cladophialophora species.
A 22-year-old woman suffered from haemoptyses of unknown aetiology. A tumour in the lingula was diagnosed histologically to be a granulomatosis, most likely a sarcoidosis. Two years later, the patient returned with dyspnoea caused by a granulomatous tumour in the trachea, histologically similar to that seen earlier. After bronchoscopic laser resection, cortisone therapy was applied but without success. A fungus was subsequently discovered histologically and was cultivated from biopsy specimens. Retrospective research of primary histological slides led to the conclusion that a mycosis was the initial cause of the tumours. The mycosis was successfully treated with high-dose itraconazole for 1 year, combined with 5-fluorocytosine (5-FC) during the first few months. The causative agent was found to be a new species of Cladophialophora, and is described as C. arxii Tintelnot; its key characteristics are presented.
Adult↗