PubMed Health⌕ Search

Biomedical subjects

K Tobisu

Publications and source records attributed to K Tobisu.

At least 73 records · Page 4Linked to original sources
PubMed1989

[Bladder replacement by enterocystoplasty after total cystectomy].

From May 1987 to April 1988, 7 male patients, 43-69 years old in age, underwent enterocystoplasty after total cystectomy. In 5 of them, a selected intestinal segment, consisted of the terminal portion of the ileum, the cecum and the proximal part of the ascending colon, was freed and detubularized for construction of "bladder" substitution. In the remaining two patients with a previous history of cholecystectomy, having severe intestinal adhesions, the ileum or the sigmoid-colon were used. At 3 months after operation, 6 patients had a vesical capacity of 300 ml or more and the maximum volume of urine excreted at one voiding was 200 ml or more. Daytime continence had been achieved in 6 patients at 3 months after operation, whereas nighttime continence had been achieved in 5 patients at 6 months after operation. Serum electrolytes, pH value of arterial blood and renal function, were all normal during the follow-up period (5-13 months). Potency was preserved in 2 patients. All the patients, except one whose "bladder" was constructed with ileum and who was performing daily intermittent selfcatheterization, were able to enjoy almost the same activity of daily life as before operation. The final shape of the "bladder" and its position in the pelvic space seemed to be an important factor for the "bladder" function after operation. By our hand, however, postoperative cystogram revealed a sigmoid shape in all cases, though the reservoirs had an oval shape at the time when they had been constructed.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Cultivation of human tumor infiltrating lymphocytes for use in adoptive immunotherapy].

We have developed a method of in vitro stimulation of TIL and PBL using immobilized anti CD3 antibody instead of autologous tumors. After this treatment, proliferation of T cells was greatly enhanced. Separated TILs were cultured by OKT3 coated 96 well culture plate for about one week with 10% human serum and 1,000U/ml of rIL-2 supplemented RPMI-1640 medium, and then transferred to plain vessels. TIL increased in number by more than 5,000-fold after 3 weeks. PBLs obtained from 10 ml of peripheral blood were cultured in OKT3-coated culture flask (75 cm2) with 10 ml of medium for about one week, and then in plain flasks and finally expanded by culture in gas-permeable culture bags. PBL proliferated by more than 1,000-fold after 2 weeks. TIL or PBL cultured by this method contained over 90% activated T cells positive for the Leu4 marker, and HLA-DR. About 60% of these were CD8-positive and about 40% were CD4-positive. Only a small number of Leu 11-positive cells were detected in every case.

Antibodies↗
PubMed1989

Prognosis in renal cell carcinoma: analysis of clinical course following nephrectomy.

The clinical courses and survivals of 159 patients who underwent nephrectomy for renal cell carcinoma are reviewed. A longer disease-free period after nephrectomy was correlated with significantly better survival. Among patients in whom metastases in the lungs or bones were detected after nephrectomy, those with between one and five pulmonary or solitary bone metastases, without definite increases in their number and size in the six months following their first appearance, survived significantly longer than patients with a similar number of metastases but which did increase in number and size in the following six months, or patients with six or more pulmonary or multiple bone metastases. Even when metastases detected after nephrectomy were confined to the lungs or bones throughout the observation period, the patients did not necessarily show significantly better survivals than patients with metastases detected in multiple sites.

Adult↗
PubMed1989

Total replacement of the bladder with an intestinal pouch for normal micturition after cystectomy.

Between May 1987 and April 1988, seven male patients aged 43-69 years underwent an operation for total replacement of the bladder with an intestinal pouch for normal micturition after cystectomy. In five, the detubularized ileocecocolic segment was used as the internal reservoir and, in the other two, the ileum or the sigmoid colon was used because of a severe adhesion of the ascending colon due to previous surgery. Three months after surgery, six patients had a vesical capacity of 300 ml or more and could excrete a maximum 200-300 ml urine at one voiding. Daytime continence was achieved in six patients in three months, and night-time continence in five patients in six months. No abnormalities in serum electrolytes, acid-base balance or renal function were observed during follow-up periods of 8-16 months. The patients were enthusiastic about this procedure, including the patient requiring occasional self-catheterization to overcome his incontinence. The follow-up periods have been short, but this method seems promising as a new internal diversion.

Aged↗
PubMed1989

Early lesions and natural progression of bladder carcinoma (minute bladder carcinoma).

Morphological analyses of minute bladder carcinomas (less than 5mm in diameter) and their natural progression to advanced carcinomas were examined. There were 71 minute carcinomas in 25 cases, the highest number in any one case being eight. The growth forms of the 71 minute carcinomas were classified into six types: papillary (35), Brunn's nest-like (20), intermediate between those two (9), simple displacing (3), inverted papillary (2) and invasive (2). There appeared to be two kinds of advanced papillary carcinoma, one forming a papillary tumor from the onset of progression, and the other, initially exhibiting Brunn's nest-like, intermediate or simple displacing tumors and finally forming papillary tumors. Some of the papillary carcinomas seemed to have developed from papillomas. Two pathways to invasive carcinomas from papillary tumor were suggested: one showing invasive growth directly from the papillary tumor, the other developing invasive changes in the proliferative processes from Brunn's nest-like or intermediate tumors. Invasive growths occurred in tumors of G2 or over and in those in which the character of the tumor was changed to that of squamous cell carcinoma. They appeared to be more frequent (four cases out of 13 compared with one out of 10) in the advanced papillary carcinomas which had seemingly developed from the various kinds of minute tumor other than papillary. Invasive minute carcinoma was regarded as being an early stage of advanced non-papillary invasive carcinoma.

Adult↗
PubMed1988

Relationship between papillary and nodular transitional cell carcinoma in the human urinary bladder.

A total of 186 cystectomized specimens were examined by step-sectioning to determine the relation between papillary and nodular transitional cell carcinomas of the urinary bladder. Tumors were classified as papillary (PC), nodular (NC), and carcinoma in situ (CIS) according to their gross and microscopic configurations. These cases, grouped as simple combinations of PC, NC, and CIS, namely, PC, PC + CIS, PC + NC, PC + NC + CIS, NC, NC + CIS, and CIS, were analyzed with respect to (a) the time from the initial symptom to cystectomy, (b) the treatment before cystectomy, (c) the grade, (d) the stage of tumors, (e) the multiplicity of tumors, (f) the presence of papillary structures inside or on the surface of nodular carcinoma, and (g) data on survival after cystectomy. Of the tumors, 17 were classified as CIS and 80 as PC and PC + CIS. Studies on 57 cases suggested an early change from PC to a mixture of PC and NC through papillonodular carcinoma during development, whereas 6 showed late development of NC during repeated recurrence of PC. These courses indicate that some cases of NC developed from PC. On the other hand, 26 cases exhibited direct progression from CIS to NC. Thus nodular invasive carcinomas may develop in two ways: by emergence of a more anaplastic cell population within a preexisting low grade papillary carcinoma; and by de novo development of an invasive nodular carcinoma directly from CIS.

Adult↗
PubMed1988

Sequential changes in the prostate of rats treated with chlormadinone acetate, testosterone and N-nitroso-N-methylurea.

An attempt was made to induce prostatic adenocarcinoma in rats. Temporary chemical castration of F344 rats was achieved by administration of diet containing 0.05% chlormadinone acetate (CMA) for three weeks. The prostate was then stimulated by three consecutive daily intramuscular injections of testosterone propionate (100 mg./kg.). On the day after the last testosterone injection, N-nitroso-N-methylurea (NMU) (50 mg./kg.) was injected intravenously. Animals were sacrificed 10 days and 4, 20, 40 and 60 weeks after NMU treatment. Well-differentiated adenocarcinomas were obtained in three of fifty-four animals (5.6%) by this treatment and a high incidence of simple hyperplasia (88%) and atypical hyperplasia (19%) was also observed at 60 weeks. More studies are necessary to develop a protocol resulting in more rapid induction of prostatic adenocarcinomas at higher incidence.

Adenocarcinoma↗
PubMed1988

Validity of short-term examination for antipromoters of bladder carcinogenesis.

Various compounds were screened for antipromoter activity in bladder carcinogenesis in rats with a view to using them clinically to inhibit postoperative intravesical ectopic tumor growth of superficial papillary bladder cancer. Their inhibitions of the effect of sodium saccharin in maintaining increased agglutinability of bladder cells by concanavalin A were examined in 4-week tests. The compounds found to inhibit the effect of saccharin were alpha-tocopherol, ascorbic acid, aspirin, all-trans aromatic retinoid, alpha-difluoromethylornithine, sodium cyanate and p,p'-diamino-diphenylmethane. Considering the toxicities of some of these chemicals, ascorbic acid and alpha-difluoromethylornithine were concluded to be the most promising for future clinical trials.

Agglutination↗
PubMed1988

Treatment of a case of asynchronous bilateral renal cell carcinomas with inferior vena caval thrombus and hepatic metastases.

A 56-year-old man underwent a right radical nephrectomy with removal of a vena caval thrombus and resection of hepatic metastases for right renal cell carcinoma. Twenty-one months after the first operation, a left renal cell carcinoma was detected which was treated with left radical nephrectomy and followed by hemodialysis. The patient then enjoyed an active life for 14 months but died 18 months after his second operation due to lung metastasis. Bilateral radical nephrectomy and hepatic resection may be justified since there is no strongly effective adjuvant therapy for such advanced cases.

Carcinoma, Renal Cell↗
PubMed1988

Imaging diagnosis of von Hippel-Lindau disease: a case report.

A patient with typical manifestations of von Hippel-Lindau disease is presented. In this 44 year-old man, cerebellar hemangioblastoma was found initially and he was operated upon at the age of 25. This was followed by retinal angiomas treated by cryocoagulation and, recently, by paresthesia of both legs and frequent shooting pains over the lower abdomen. A computed tomography disclosed multiple small cysts of the pancreas, bilateral multicentric renal carcinomas and a spinal angioma in the lumbar portion, confirmed by magnetic resonance imaging, and consistent with neurogenic manifestations. Multiple enucleations of the renal cell carcinomas were carried out, most of which were histologically well differentiated adenocarcinomas. There was no family cluster. Six months postoperative, the patient is doing well.

Adult↗
PubMed1987

Thymic enlargement following treatment for a metastatic germ cell tumor: a case report.

We describe a patient with metastatic testicular carcinoma in whom an anterior mediastinal mass developed 8 months after complete remission following chemotherapy and surgery. The mass was excised and pathological examination showed benign thymic hyperplasia. An anterior mediastinal mass encountered after successful chemotherapy does not always imply recurrence or relapse of malignant disease. The possibility of a benign etiology must be considered to prevent inappropriate treatment.

Adult↗