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K Trnavský

Publications and source records attributed to K Trnavský.

At least 19 recordsLinked to original sources
PubMed1992

[Pharmacotherapy of rheumatoid arthritis in 1992].

The author presents an overview of the state of pharmacotherapy of rheumatoid arthritis in 1992. In the area of non-steroidal antirheumatic drugs attention is drawn to some problems associated with their undesirable action on the digestive tract and articular cartilage. The problem of interindividual reactivity to this group of drugs has not been resolved so far. The mechanism of their action, in particular analgetic action, is also still open. It was found that they can exert not only a central but also a peripheral action. Drugs modifying the disease have been extended by sulphasalazine, methotrexate and cyclosporin. Interest in combined treatment with these drugs is increasing as well as attitudes to the strategy of their application. The corticoid group has been extended by the preparation deflazacort which does not have a catabolic effect on osseous tissue. In the posology of corticoids pulsed treatment is gaining support.

Anti-Inflammatory Agents, Non-Steroidal↗
PubMed1992

Affinity chromatography of serine proteinases from the bovine intervertebral disc on BPTI-Separon HEMA 1000.

A method for the purification of serine proteinases from the bovine intervertebral disc using affinity chromatography on basic pancreatic trypsin inhibitor (BPTI) immobilized to the hydroxyalkyl methacrylate copolymer Separon HEMA 1000 E is reported. Its advantage is the possibility of obtaining serine proteinases without an artificial alteration in relative molecular mass.

Animals↗
PubMed1991

Effect of selected antirheumatic drugs on the metabolism of cartilage and synovial tissue in experimental arthropathy.

The effects of several antirheumatic drugs on the activity of degradative enzymes in normal and pathologic knee joint cartilage and on the proliferative activity of synovial tissue cells were studied. Inflammatory arthropathy was induced in rabbits by intraarticular papain administration. Elevated contents of proteoglycanase and collagenase, together with an increase in serine and cysteine proteinase inhibitors, were found in animals with papain-induced arthropathy. Inflammation also accelerated the rate of proliferation of cells present in the synovial tissue. In the treated animals, the reduction in enzyme activity, decrease in inhibitor content and decreased DNA proliferation rate were registered to a different degree. The suppression of protein synthesis by nonsteroidal antiinflammatory drugs may explain our findings. The best therapeutic results were achieved with glycosaminoglycan polysulphate (Arteparon).

Animals↗
PubMed1991

Autoantibodies against histones and actin in patients with rheumatic diseases assessed by the western blot method.

Using the Western blot method, the authors analyzed 85 sera obtained from patients with rheumatic diseases, focused on the presence of antihistones and antiactin autoantibodies. The authors detected a 32% incidence of the two investigated autoantibody specificities. In a group of 42 patients with systemic lupus erythematosus in 22 sera (52%) positive antihistone antibodies were present, whereby autoantibodies anti-H1 and anti-H2B were most frequent. In 15 sera in this group of patients (36%) antiactin autoantibodies were present.

Actins↗
PubMed1991

[Indicators of articular cartilage degeneration in synovial fluid].

Detection of proteoglycans in biological fluids is a perspective method for the evaluation of the degree of catabolic processes in articular cartilage. The demand of accuracy and specificity of detection of substructures of the degradation products of the cartilaginous matrix, with the perspective of routine large scale examinations, restricts available possible methods practically only to the use of immunochemical methods. In the present investigation in the inhibitory ELISA test polyclonal antibodies with a double specificity in relation to basic structures of the cartilage--proteoglycans--were used. The highest concentrations of degradation products of proteoglycans in punctates of synovial fluid were found in diseases where the clinical picture is dominated by repeated attacks of the joints with longer remission periods, and where the attack is stimulated, usually by stimuli of an intermittent systemic or exogenous character (gout, reactive arthritis incl. Reiter's syndrome, Lyme disease).

Antigen-Antibody Reactions↗
PubMed1990

[Autoantibodies against histones and actin determined by western blotting in patients with rheumatic diseases].

Using the Western blot method, the authors analyzed 85 sera obtained from patients with rheumatic diseases, focused on the presence of antihistones and antiactin autoantibodies. The authors detected a 32% incidence of the two investigated autoantibody specificities. In a group of 42 patients with systemic lupus erythematosus in 22 sera (52%) positive antihistone antibodies were present, whereby autoantibodies anti-H1 and anti-H2B were most frequent. In 15 sera in this group of patients (36%) antiactin autoantibodies were present.

Actins↗
PubMed1990

Agranulocytosis in a patient with primary Sjögren's syndrome.

The authors describe a case of primary Sjögren's syndrome, which was complicated with severe autoimmune agranulocytosis quite sensitive to immunosuppressive therapy. Agranulocytosis is a very rare complication of this autoimmune rheumatic disease as opposed to leucopenia. A remarkable feature of the presented case is the fact that correct diagnosis of primary Sjögren's syndrome has not been settled for almost 25 years. The disease has manifested only in the form of arthropathy imitating rheumatoid arthritis.

Agranulocytosis↗
PubMed1989

[Salazosulfapyridine (sulfasalazine)in inflammatory rheumatic diseases].

Salazosulphapyridine is a salicyl derivative of the sulphonamide sulphapyridine. Although its introduction into clinical practice in rheumatology is not recent, only clinical investigations during the last decade proved convincingly its favourable therapeutic effect in rheumatoid arthritis and in some diseases from the group of seronegative spondarthritis. The onset of the therapeutic response after a latency of several weeks, the influence on the laboratory and clinical indicators of the activity of the rheumatic inflammatory response and the concurrent retardation of the development of articular destructive changes on the X-ray picture in some of the patients justify the inclusion of salazosulphapyridine into the group of drugs which modify the course of the disease. The results of hitherto made investigations confirmed also a relatively good tolerance of salazosulphapyridine.

Arthritis, Rheumatoid↗
PubMed1989

[New findings on the pathogenesis of rheumatoid arthritis].

In the submitted review the authors present some new findings and approaches pertaining to the pathogenesis of rheumatoid arthritis (RA). First they describe cells participating in the development of the articular inflammation and mediators which transmit signals between these cells and which may lead to their activation. The authors mention the immune complex role of rheumatoid factors and some new theories on their development. They describe effector substances directly responsible for the resulting damage and emphasize their final role in the entire cycle preceding the inflammatory reaction in which lymphocytes, macrophages, polymorphonuclear leucocytes and dendritic cells participate. The possible role of viruses in the aetiology of RA is also mentioned. In the conclusion the authors present the sequence of mechanisms which lead to the development and maintenance of the chronic inflammatory reaction which develops probably on the background of the persisting autologous mixed lymphocytic reaction.

Arthritis, Rheumatoid↗
PubMed1989

[Amyloidosis in plasmacytic myeloma with dominant manifestations of joint involvement].

The authors describe a case of plasmocytic myeloma complicated by the development of systemic amyloidosis. The symptoms were dominated by marked macroglossia and arthropathy which by the objective finding and subjective manifestations imitated rheumatoid arthritis. In the discussion the authors emphasize general manifestations of amyloid arthropathy.

Aged↗
PubMed1989

[Perspectives in the development of basic treatment of osteoarthritis].

In a brief review the authors present findings on osteoarthritis, a heterogeneous disease with a multifactorial pathogenesis. Knowledge of morphological and biochemical changes of cartilage are the basis for reflections on the perspectives of basal treatment of this disease, i.e. treatment which will arrest progression of pathological changes. Influencing of the enzymatic degradation of cartilage, some cytokines and the inflammatory process are at the contemporary state of knowledge the only target processes which could be affected by treatment and which could lead to a fundamental modification of tissue changes in osteoarthritis.

Humans↗
PubMed1989

[Indicators of the advance and rate of progress of radiographic changes in patients with rheumatoid arthritis and their correlation with clinical and laboratory criteria].

In a double blind study with hydroxychloroquine sulphate used for treatment of rheumatoid arthritis the correlation of six X-ray criteria of progression of RA, based on calculation of the narrowing of the articular spaces and erosions (Sharp and Amos) and 23 clinical and laboratory criteria was assessed. Before treatment a satisfactory correlation of the majority of clinical and laboratory criteria with X-ray criteria was found. As after one-year treatment the majority of clinical criteria improved significantly and X-ray criteria did not differ significantly before and after treatment, the authors found very few correlations between changes of clinical and X-ray criteria, in particular after a dose of 20 mg/day. The X-ray criteria recommended by Sharp and Amos are not sensitive enough to be used for the evaluation of changes of the X-ray picture after one-year treatment with anti-rheumatic drugs which modify the course of RA. This applies in particular to more advanced cases.

Arthritis, Rheumatoid↗
PubMed1989

[Initial experience with the treatment of rheumatoid arthritis by dietary manipulation].

The purpose was to assemble experience with the treatment of rheumatoid arthritis with fish oil and to compare the results with reports from abroad. The investigated group comprised 10 women who suffered from confirmed RA. The patients were treated by nonsteroid antirheumatic drugs. During the trial processed fish oil [Martens'oil], 10 g/day was added. The tolerance of the preparation was good. The investigation period lasted three months. After one-month intervals laboratory and clinical indicators of the activity of the disease were investigated and compared with baseline values before treatment. All investigated values improved, however, only some significantly: the level of C-reactive proteon, pain on movement, the articular index, morning stiffness. The latex-fixation test was in all patients positive at the beginning and at the end of the investigation. Fish oil as a dietetic supplement of treatment with non-steroid anti-rheumatic drugs gives the patients subjective relief, the results of preliminary observations indicate the necessity of further, in particular double blind trials.

Arthritis, Rheumatoid↗
PubMed1989

Hydroxychloroquine sulphate in the treatment of rheumatoid arthritis: a double blind comparison of two dose regimens.

A controlled, double blind, parallel group, long term study of hydroxychloroquine sulphate in the treatment of rheumatoid arthritis, comparing daily doses of 200 mg and 400 mg, is described. The trial involved 54 patients with moderate disease activity who had not previously received antimalarial drugs. Forty three patients completed the one year treatment. The groups receiving different doses were homogeneous and did not differ in any of the 25 monitored indicators. Both dose regimens were effective, and a significant reduction of disease activity was observed after one year's treatment. Of the nine laboratory and 11 clinical indices of efficacy monitored, no statistically significant differences were reported, but in the group of patients treated with the 400 mg daily dose the number of side effects was three times greater. As there have been no reports of retinopathy with hydroxychloroquine at daily doses of 200 mg the effectiveness of this dose is of practical importance.

Arthritis, Rheumatoid↗