PubMed Health⌕ Search

Biomedical subjects

K Trotter

Publications and source records attributed to K Trotter.

7 recordsLinked to original sources
PubMed2001

Clinical validation of the Bedbugg in detection of obstructive sleep apnea.

OBJECTIVE: To validate the accuracy of the Bedbugg, a new home monitoring device for diagnosis of obstructive sleep apnea. STUDY DESIGN AND SETTING: Simultaneous sleep monitoring was performed by formal polysomnography and by Bedbugg. Monitoring was performed in a university sleep center in 42 subjects who had previously been scheduled for polysomnography. RESULTS: The correlation for the apnea-hypopnea index (AHI) between polysomnography and Bedbugg was r = 0.96. The sensitivity of Bedbugg for detecting an AHI > 15 was 85.7%. The specificity of Bedbugg for detecting an AHI < 15 was 95.2%. CONCLUSION: The Bedbugg device provides an accurate assessment of the apnea-hypopnea index. SIGNIFICANCE: Accurate home monitoring for sleep apnea may provide access to care for a higher proportion of undiagnosed sleep apnea patients.

Adult↗
PubMed2000

Pitfalls in patch testing.

Patch testing is an invaluable diagnostic tool in the evaluation of allergic contact dermatitis. While TrueTest has simplified the technique for many practitioners, there remains potential for error. We asked 4 experts to describe their approach to several dilemmas encountered in patch testing. Their responses will be helpful to both the veteran and tyro.

Bias↗
PubMed2000

PKA holoenzyme is functionally coupled to CFTR by AKAPs.

Cystic fibrosis transmembrane regulator (CFTR) is reported to be preferentially regulated by membrane-bound protein kinase A (PKAII). We tested for close physical and functional association of PKA with CFTR in inside-out membrane patches excised from Calu-3 cells. In the presence of MgATP, 8-(4-chlorophenylthio)adenosine 3',5'-cyclic monophosphate (CPT-cAMP) increased the product of CFTR channel number and open probability (from 0.36 +/- 0.12 to 1.23 +/- 0.57, n = 20, P < 0.0025), and this stimulation was abolished by PKI. Thus Calu-3 membrane isolated from cells retains PKA holoenzyme that is functionally coupled to CFTR. PKAII is anchored at specific subcellular sites by A kinase anchoring proteins (AKAPs). Exposure of excised patches to HT-31, a peptide that disrupts the association of PKAII and AKAPs, prevented CPT-cAMP stimulation of CFTR. Therefore, PKA holoenzyme in isolated membrane patches is bound to AKAPs. In whole cell voltage-clamp studies, intracellular dialysis of Calu-3 cells with HT-31 blocked the activation of CFTR by extracellular adenosine. These results suggest that AKAPs mediate PKA compartmentalization with CFTR and are required for activation of CFTR by physiological regulators.

Adenosine Triphosphate↗
PubMed1987

Cognitive activity and cutaneous blood flow.

Serial subtraction and multiplication problems were performed orally by 21 healthy human subjects during two three-minute periods separated by a 22-minute rest interval. During the period of mental activity, cutaneous blood flow in the finger fell to 59%, digital cutaneous pulse pressure fell to 62%, and heart rate increased by 24% of the subjects' initial baseline values. Cutaneous blood flow in the malar region did not change. Because vasomotor control of the finger skin is principally vasoconstrictor and that of the malar area vasodilator, these results suggest that mental activity unrelated to obvious stress may provoke changes in cutaneous blood flow in areas controlled by sympathetic vasoconstrictor fibers. Simultaneous changes in digital cutaneous blood flow, digital cutaneous pulse pressure, and heart rate indicate an autonomic-mediated effect.

Adult↗