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Biomedical subjects

K Trznadel

Publications and source records attributed to K Trznadel.

At least 37 records · Page 2Linked to original sources
PubMed1984

Release of neutrophil granule factors during early period of hemodialysis: a possible cause of hemodialysis neutropenia.

In the early phase of hemodialysis progressive decreases in some enzyme activities in the leukocyte homogenate, neutrophil granule fraction and postgranular supernatant were found with concomitant rise in plasma beta-glucuronidase activity, which is indicative of the release of neutrophil granule factors into the extracellular environment. Intravenous infusion of human neutrophil granule products to rabbits induced profound transient neutropenia. The results suggest that the release of neutrophil granule factors in the early period of hemodialysis may be a possible cause of hemodialysis neutropenia.

Adult↗
PubMed1983

Ultrastructural appearances of nephron damage in acute poisoning with ethylene glycol.

Renal biopsy material from five patients with acute ethylene glycol poisoning was taken five, 10, 16 and 22 days following poisoning and examined by electron microscopy. We found extensive crystal deposits in glomerular interloop spaces. In some of the tubules crystal accumulation seemed independent of time following poisoning. No morphological markers of reabsorption were found in the tubules tightly filled with crystals, while tubules with empty lumen had signs of enhanced reabsorption. In the early period of poisoning there were signs of epithelial damage while in the late periods, signs of epithelial regeneration prevailed. The results provide new information on the pathogenesis of anuria in acute poisoning with ethylene glycol.

Ethylene Glycols↗
PubMed1980

The left ventricular systolic function after digoxin administration in patients with chronic renal failure.

The responses in the left ventricular systolic time intervals following digoxin administration (0.5 mg i.v.) were studied in 11 patients with chronic renal failure and hypertension. The control group comprised 11 patients with mild essential hypertension. There were no clinical signs of congestive heart failure in any of the patients. Before digoxin administration total electromechanical systole (QS2), the pre-ejection period (PEP) and the PEP/LVET ratio were greater, while the left ventricular ejection time (LVET) was shorter than in the control group (P < 0.001). In patients with chronic renal failure digoxin administration induced a reduction in QS2, PEP and PEP/LVET ratio and a prolongation of LVET (P < 0.001). These data suggest latent heart failure in the group of patients studied with chronic renal failure. It seems to be advisable to use digitalis preparations in patients with chronic renal failure despite the absence of clinical signs of heart failure.

Adult↗
PubMed1978

Comparative studies on the effect of hemoperfusion and hemodialysis on the elimination of some uremic toxins.

This study, performed on patients with terminal renal failure, compares the changes in plasma concentrations of middle molecules, myoinositol, low molecular weight metabolites, and blood components during 4 hour periods of hemodialysis and hemoperfusion over a charcoal cartridge. After hemoperfusion there is a more marked decrease of adsorbable substances such as middle molecules, creatinine, and uric acid, whereas after hemodialysis there is a greater change in serum concentrations of myoinositol, urea, and electrolytes. The findings show that although hemoperfusion over a charcoal cartridge cannot replace hemodialysis in the treatment of chronic renal failure, it is effective as a complementary method, because of the better removal of some uremic toxins.

Blood Platelets↗