Biomedical subjects

K Tsunashima

Publications and source records attributed to K Tsunashima.

11 recordsLinked to original sources

PubMed1990

The effect of delta sleep-inducing peptide (DSIP) and phosphorylated DSIP (P-DSIP) on the apomorphine-induced hypothermia in rats.

Delta sleep-inducing peptide (DSIP) and P-DSIP, phosphorylated analogue, were found to have enhancing effects on hypothermia induced by i.p. injection of apomorphine (2 mg/kg), a dopamine agonist. Further, the action of P-DSIP appeared and diminished more quickly than that of DSIP. A minimal effective dose of these peptides was 10 ng and the dose-response relationship exhibited an inverted bell-shape with a maximal effective dose of 1 microgram. By the pretreatment of anti-DSIP the enhancing effect of DSIP but not P-DSIP, was totally abolished and the action of both peptides was antagonized by haloperidol. These findings suggest that DSIP and P-DSIP have a close relation to the dopaminergic system on the thermoregulatory mechanisms.

Animals↗

PubMed1987

A neuroendocrinological study of responders and non-responders to ceruletide treatment in chronic neuroleptic-resistant schizophrenia.

To define the characteristics of chronic schizophrenic patients who had responded poorly to treatment with ceruletide, several neuroendocrinological tests were carried out in 5 responders and 5 non-responders. Both thyroid-stimulating hormone and prolactin responses to thyrotropin-releasing hormone stimulation were within normal ranges in all subjects. The luteinizing hormone response to luteinizing hormone-releasing hormone, was slightly weaker in non-responders. There were no differences in the insulin tolerance test between responders and non-responders. Unusually delayed or prolonged growth hormone response to arginine infusion was observed in non-responders. These findings suggest dysfunction of the hypothalamo-pituitary system, especially of the arcuate nucleus and its functionally related areas, in non-responders.

Antipsychotic Agents↗

PubMed1983

Changes in pituitary-adrenal function under continuous exposure to hypoxia in male rats.

The plasma corticosterone concentration and incorporation of 14C-1-acetate into adrenocortical hormones were measured in male rats exposed to hypoxia (12.5% O2 in N2 balance) for periods of 30 min--14 days. Hypoxia significantly increased the weight of the adrenal and pituitary glands in early stages of exposure. However, weight returned to the control level on the 14th day of exposure. Hypoxia consistently decreased the weight of the thymus. Hypoxia elevated the plasma corticosterone concentration in the early stages of exposure. However, the elevated corticosterone level gradually decreased by the 7th day. The corticosterone level at this stage was lower than in the control. The corticosterone concentration returned to the control level on the 14th day. Hypoxia significantly facilitated incorporation of 14C-1-acetate into corticosterone and cortisol in the adrenal homogenate. The elevated incorporation was maintained until the 7th day and gradually decreased to the control level there after. Body weight was decreased by hypoxia (12 gram in 24 hours). On the 5th day, the weight returned to the control level. Hematocrit increased gradually during 14 days of hypoxia exposure. These results suggest that pituitary-adrenal function is greatly facilitated by 1-6 hours of hypoxia exposure, and hypoxia acclimatization is accomplished humorally within 14 days of exposure in rats.

Acetates↗

PubMed1979

[A study of the stress distribution of the stem of the total hip prosthesis (author's transl)].

By attaching the strain gauges on the inner and outer sides of the stem of the total hip prosthesis composed of Müller, Charnley and domestic SOM type, the stress distribution was measured. At first, the center of the head of the prosthesis and the apex of the stem were adjusted to be on the vertical line, and a vertical load was placed on the uppermost end of the head, then the stress was measured. Next, the stem was fixed in the hole of a wood-block containing acrylic resin, and the load was placed on the head in neutral, 10 degrees valgus and 10 degrees varus position and in the direction same as the stem before fixation, then the stress was measured of respective position. In comparing the difference in stress distribution between the fixed and the non-fixed stem, the stress in the case of the fixed stem proved to be 17--32% that of the non-fixed one. The site where the maximum stress appeared was at the middle third of the stem in the case of the non-fixed stem, while it was at the neck and at the one fifth of the upper portion of the fixed one. In comparing the stress at the neutral, the valgus and the varus position, the stress at the valgus position was found to be minimum, and taking the stress at the neutral position as 100, it was 60--82, and at the varus position the maximum of 105--131 appeared.

Biomechanical Phenomena↗

PubMed1979

A case of bilateral primary posterior dislocation of the shoulder.

We present a case of bilateral primary dislocation of the shoulder, which was treated operatively on the left and conservatively on the right side. Primary posterior dislocation of the shoulder is rarely seen and bilateral case is extremely rare. For the diagnosis it is essential to have a knowledge of this dislocation. As to roentgenographic examination, the axillary projection is most helpful but can't be routinely taken because of severe pain and limited abduction of the shoulder. So special roentgenographic techniques are necessary.

Adult↗

PubMed1977