Accurate measurement of the extent of hand swelling in patients with rheumatoid arthritis.
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Adolescent↗
Biomedical subjects
K Tveter
Publications and source records attributed to K Tveter.
Hydroxylation of testosterone in the human testis. Identification of 4-androstene, 7 alpha,17 beta-diol-3-one (7 alpha-hydroxytestosterone) as a metabolite of testosterone.
Homogenates of normal or cryptorchid, human testes were incubated with [3H]testosterone and a NADPH-generating system. [3H]4-andostene,7 alpha,17 beta-diol-3-one (7 alpha-OH-testosterone) was isolated and identified from such incubations. To our knowledge this is the first demonstration that 7 alpha-OH-testosterone is a metabolite of testosterone in the human testis. 4-Andro-stene,6 beta,17 beta-diol-3-one (6 beta-OH-testosterone) and 4-androstene,16 alpha,17 beta-diol-3-one (16 alpha-OH-testosterone) were also identified as testosterone metabolites. The specific activity of both testosterone 6 beta- and 16 alpha-hydroxylase was higher than that of 7 alpha-hydroxylase. Pre-pubertal or cryptorchid human testis tissues seem in our study to have higher testosterone 6 beta- and 7 alpha-hydroxylase activity than normal adult testis tissue.
Adolescent↗
The ultrastructure of the accessory sex organs of the male rat. 9. The effect of an antiandrogenic compound, SKF 22,340.
The coagulating gland and the dorsal lobe of the rat prostate were studied after administration of the antiandrogenic compound SKF 22,340. There was a general involution of the organs, with macroscopic atrophy and a reduced amount of secretory material. Ultrastructurally the cells contained fewer organelles as compared with the controls. There were also loss of cytoplasm and reduction both of cell height and width. Within the dorsal lobe, prominent nuclear and nucleolar changes were found. The alterations observed in the present study are similar to changes which were found in animals treated with another antiandrogenic compound, cyproterone acetate. The results are discussed in relation to the available biochemical data.
Androgen Antagonists↗