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Biomedical subjects

K V Sudakov

Publications and source records attributed to K V Sudakov.

At least 19 recordsLinked to original sources
PubMed1998

[Systemic organization of brain functions: key role of results action acceptor].

The paper presents general principles of organization of human psychic functions on the basis of P.K.Anokhin's theory of functional systems. The peculiarities of forming psychic activity are analyzed on the information basis of systemic activity of brain. The key role in management of psychic activity belongs to foreseeing of required results, i.e. the acceptor of action's results. Holographic and molecular mechanisms of forming informative engram of acceptor of action's results are considered.

Animals↗
PubMed1998

[Mechanisms of resistance to emotional stress: advantages of individual approach].

cal concern for widespread averaged approach to studying various stress indices is presented. The author demonstrates that the subjects predisposed and resistant to different physiological dysfunctions and survival are revealed in a great variety of experimental models and experiments. The animals resistant and predisposed to emotional stress are shown to present different behavior, autonomic reactions, varying rates of c-fos gene expression in the brain, different levels of catecholamines and oligopeptides in the brain structures. Specific chemical integration of neurons in the limbic-reticular brain structures determines animal resistance to emotional stress.

Animals↗
PubMed1997

[Systems evaluation of physiological functions of humans at a workplace].

The paper gives experimental findings of the application of the Anokhin theory of functional systems to the evaluation of human physiological functions in a working place. It is shown that the correlations of the heart and respiration rates with the effective productive activity quanta may characterize the specific features of autonomic regulation in workers and objectively suggest the occurrence of their psychoemotional stress in their working place. Disintegrated autonomic correlations in the productive activity quanta reflects impaired multicomponent interactions of homeostatic functional parameters, by ultimately causing an abnormality.

Adolescent↗
PubMed1997

[Emotional stress and blood melatonin levels].

Blood serum melatonin concentrations were measured in male Wistar rats exposed to acute water-immersion emotional stress (ES) during intraperitoneal injections of physiological saline or different doses of melatonin. ES increased blood melatonin levels in rats receiving physiological saline 1 hour before or just after ES. When physiological saline was administered just ES, blood melatonin concentrations remained unchanged. The blood levels of melatonin both in control and stressed animals injected with exogenous melatonin were higher than those in rats given physiological saline alone. Immersion ES decreased blood melatonin concentrations in rats receiving different exogenous melatonin doses just before ES. However, in rats given melatonin, 1.0 mg/kg, after ES, its blood levels after ES was higher than those in the animals unexposed to stress. The findings suggest that it is just exogenous rather than endogenous melatonin that is consumed in rats injected with its different doses just prior to immersion ES.

Animals↗
PubMed1997

Effects of acute emotional stress on the brain and autonomic variables.

Under emotional stress (ES) the brain limbic-reticular structures are shown to change first. The integrative interaction of brain structures determines the secondary changes of cardiovascular functions. The effects of ES on autonomic functions are mediated primarily by chemical changes of brain limbic-reticular neurons to neurotransmitters and oligopeptides. Genetic and individual cardiovascular disorders under ES have been demonstrated. Mechanisms of sustained arterial blood hypertension under experimental ES are considered. It has been established that the resistance to ES is strongly dependent on the basic levels of oligopeptides and norepinephrine in the hypothalamus. Additional injections of oligopeptides enhance the resistance to ES.

Acute Disease↗
PubMed1997

[Information properties of functional systems: theoretical aspects].

Information resonance properties of functional systems of different organization levels. The formulated concept states that the dynamic architectonics of functional systems, based on a holographic principle, includes a special kind of an information screen which serves as an apparatus for estimation of the status, which is useful for the body. The hypothesis suggests that the information screen is molecularly represented by membranes, enzymes, and liquid crystals--by DNA and RNA molecules, as well as homeostatically by colloids and biologically active information molecules of connective tissues; cerebrally by glial colloids, DNA and RNA molecules of neurones which form the acceptor of action results apparatus of different functional systems. The idea of information screens of functional systems at the population levels and of human population interaction with space phenomena is formulated.

Animals↗
PubMed1997

[The action of a modulated electromagnetic field on the emotional component of the systemic organization of behavioral acts in rats].

Experimental findings are reviewed in respect to the effect of modulated electromagnetic field (MEMF) upon emotional responses of rats accompanying various phases of systemic organisation of their behaviour. Blocking effects of the MEMF are shown in simulated self-stimulation and various conditioned types of behaviour in rats. In author's opinion, the MEMF affect the informative component of behaviour: emotions.

Animals↗
PubMed1996

[The systemic integration of human functions: new approaches to the diagnosis and correction of stressor states].

The paper provides evidence for a new principle of the systemic organization of human functions. Instead of the concepts of man as a set of organs which are bound up with nervous and humoral regulation, the author considers on the basis of the functional systems theory the human body as a total combination of various interacting systems of different levels of organizations, each yields body's useful adaptive responses on the principles of multiparametric and successive interactions with other functional systems. The paper reveals the principles of interaction of functional systems in the whole organism. Problems in the evaluation of human physiological functions in the place of work, systemic principles of detection of stress states and their rehabilitation are considered in the context of functional systems.

Adaptation, Physiological↗
PubMed1996

[Evaluation of stress at the workplace: systemic approach].

According to Functional Systems Theory suggested by P.K.Anokhin, the authors assessed physiologic parameters of workers at the workplace in accordance with results of occupational activity portions. Correlation between pulse and breathing rates appeared to be an objective criterion of emotional stress and fatigue. The specific experiments on animals and observations of workers in real industrial conditions revealed depression of correlation coefficient "Pulse Rate-Breathing Rate" in emotional stress. That coefficient appeared to be significantly lower in beginners and poorly trained subjects if compared to qualified professionals and well trained workers.

Adolescent↗
PubMed1995

Delta-sleep-inducing peptide sequels in the mechanisms of resistance to emotional stress.

The aim of this study is to investigate time-related changes in substance P (SP), beta-endorphin (BE), and corticosterone (CORT) levels due to DSIP aftereffects in the control and stress rats. Experiments were carried out on male Wistar and August rats. The SP and BE immunoreactivity in the hypothalamus and plasma samples was determined radioimmunologically. Blood CORT level was determined radioimmunologically. The rats were stressed at nighttime in special cages and tied by tails to the back side of the cage. The stress experiments were repeated for 12 hours for 5 days. There were 6 groups: 1. control animals, 2. stress animals, 3. rats that received DSIP in a dose of 60 nmol/kg one hour before decapitation, 4. rats in which DSIP was injected 24 hour before decapitation, 5. stressed rats in which DSIP was injected one hour before decapitation during the 5th exposure to stress, 6. stressed rats to which DSIP was injected 12 hours before the 5th exposure to stress, i.e., 24 hours before decapitation. Our experiments showed that DSIP administration induced marked changes in SP, BE, and CORT levels in hypothalamus and blood plasma. This suggests that the long-term stress-coping effect of DSIP depends on considerable changes in the level of other oligopeptides and hormones induced by DSIP. Evidently, DSIP triggers these processes inducing a cascade of interrelated molecular reactions radically different in animals with different resistance to emotional stress. This cascade of sequential reactions is different in Wistar and August rats differing by their resistance to emotional stress. DSIP administration stimulates the mechanism of resistance in August rats to a lesser extent than in Wistar animals.

Animals↗