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K Vajda

Publications and source records attributed to K Vajda.

16 recordsLinked to original sources
PubMed2001

[Epidermoid cyst of the cecum].

This paper describes a case of an epidermoid cyst arising in the anterior wall of the coecum. Epidermoid and dermoid cysts of the coecum are exceptionally rare. These cysts arise by the sequestration of squamous epithelium during embryological development, or following trauma or surgery. The true cysts are the result of inclusion or sequestration of ectodermal elements at the time of closure of the neural groove. Acquired epidermoid cysts are of traumatic or iatrogenic origin, due to implantation of the epidermis. In this reported case the patient had no previous abdominal surgery which is why this cyst represents the congenital variant of the disease.

Adult↗
PubMed1999

[Meckel diverticulum as a possible source of complications].

The authors performed a retrospective analysis of 108 operations performed because of Meckel's diverticulum from Jan. 1, 1980 until Dec. 31, 1997. 87 incidental operations were performed (80.55%) and 21 operations were performed (19.54%) because of complications of Meckel's diverticulum. Of the 87 incidental cases, 44 were males and 43 were females. The diverticulum was resected in 70 cases, was inverted in 16 patients and was left untouched in 1 patient. There were postoperative complications in 10 cases (11.5%), however, only one complication was related to the diverticulum operation. There was one death due to pneumonia in the incidental group (1.14%). Of the 21 cases having complications there were 5 females and 16 males. The following complications were observed: 4 cases of ileus, 7 cases of perforation (a foreign body was found in two cases) and 10 cases of inflammation. The Meckel's diverticulum was resected in 19 cases and the small intestine was resected in 2 cases. Postoperative complications occurred in 3 cases (14.3%), however these were not related to the diverticulum operations. There were 2 deaths due to pneumonia and pulmonary embolism (9.5%). Histological examination revealed 7 cases of heterotopic gastric mucosa in both the incidental group and the group with complications. There was one case of heterotopic pancreatic tissue in the group with complications. The incidence of heterotopy in the incidental group was 8%, whereas in the group with complications the incidence was 33.3%. Histological examination also revealed reflux gastritis-like diverticulitis in 5 of the patients with heterotopic gastric mucosa. Meckel's diverticulum was diagnosed in 2 patients preoperatively by upper gastrointestinal series.

Adult↗
PubMed1999

Nodal staging of colorectal carcinomas from quantitative and qualitative aspects. Can lymphatic mapping help staging?

Retrospective data analysis was performed to determine the minimum number of lymph nodes required for the staging of colorectal carcinomas, and a prospective feasibility study was carried out to identify sentinel nodes in order to clarify whether these may predict the nodal status. From among 240 colorectal carcinoma specimens investigated between 1996 and 1998, 224 tumors were analyzed for their nodal status. Lymphatic mapping with vital patent blue dye injection into the peritumoral sub-serosal layer was performed in 25 patients. Blue nodes were identified by the pathologist in the unfixed specimen immediately after the resection of the bowel and were assessed separately. Of the 123 node-positive carcinomas, 40 had more than 3 nodes involved. The nodal positivity increased substantially when more than 6 nodes were assessed. The cumulative percentage analysis demonstrated that ideally 16 and 13 nodes should be obtained for the identification of any nodal involvement or the involvement of more than 3 nodes, respectively. Lymphatic mapping was successful in 24 patients (96%). Blue nodes were predictive of the nodal status in 19 cases (79%), and were the only sites of metastasis in 2 patients (15% of the node-positive cases). Lymphatic mapping with the vital blue dye technique does not seem to facilitate the staging of colorectal cancers, at least in our patient population with relatively large and deeply infiltrating tumors, and unless the technique is improved or other selective features of lymph nodes are found, all lymph nodes should be assessed. A minimum of 6 nodes, and an optimum of 16 nodes or more, are suggested from these series.

Adult↗
PubMed1998

[Prognostic factors in breast cancer].

Prognostic factors are clinical and pathological features that give information in estimating the likely clinical outcome of an individual suffering from cancer. The author gives a short review of the most important prognostic factors in breast cancer. 376 breast cancer cases of a ten year interval in a county hospital are summarized. Traditional clinico-pathological parameters i.e. TNM and steroid receptor status are discussed. The more common karyotipic, oncogene and tumor suppressor gene alterations are outlined in the study. Methods for their detection are presented and their value in prognostication is reviewed. Emphasis was laid on steroid receptors, c-erpB-2, p53 and bcl-2 alterations. Genes responsible for heritable forms of increased breast cancer risk are briefly reviewed.

Adult↗
PubMed1997

[Angiodysplasia as source of hemorrhage].

UNLABELLED: Gastrointestinal bleeding of unknown origin presents a difficult diagnostic problem. The authors show 2 angiodys plasiastic cases. In the first case the clinical history contains multiple examinations and transfusions because of anaemia. The diagnosis was achieved by selective angiography. In the antrum of the stomach justified angiodysplasia was accompanied by aortic valve disease. Billroth I. operation was performed. In the other case anoscopy, colonoscopy and gastroscopy was necessary because of massive rectal bleeding but in the lack of bleeding source they performed right hemicolectomy due to hypothetical cecum angiodysplasia. The supposed diagnosis was proven by histology. CONCLUSION: in the case of unknown bleeding sources especially in older patients angiodysplasia should be considered more often and selective angiography should be indicated.

Aged↗
PubMed1996

[Myofibroblastoma of the lymph nodes].

We report a case of intranodal myofibroblastoma occurring in a lymph node of the left inguinal region of a 53 years old female. This tumor was first described 6 years ago and has not been yet documented in the Hungarian literature. This rare benign mesenchymal neoplasm of the lymph node occurs almost exclusively in the inguinal region. Histologically the tumor is characterized by interlacing fascicles of spindle cells which show nuclear palisading and the presence of hemorrhage. Immunohistochemically, the tumor cells were positive for actin and vimentin. Electronmicroscopic investigation demonstrated features characteristic for myofibroblastic origin. Characteristic amianthoid structures were occasionally present. It is important to distinguish this tumor entity of other primary or secondary mesenchymal neoplasms of lymph nodes including nodal involvement of Kaposi's sarcoma, a lesion it may closely resemble.

Female↗
PubMed1995

[True malignant mixed tumor of the parotid gland (carcinosarcoma)].

True malignant mixed tumor (carcinosarcoma) is a rare salivary gland tumor. In contrast to malignant mixed tumor, which means carcinoma ex pleomorphic adenoma in true malignant mixed tumor both carcinomatous and sarcomatous features are present in the same tumor. This report presents the case of a 43 year old man with a carcinosarcoma of the right parotid gland. Carcinomatous component was high grade ductal carcinoma. Mesenchymal component showed the features of giant cell type malignant fibrous histiocytoma. The diagnosis was supported by positive staining for cytokeratin in the carcinomatous part and positive vimentin, alpha-1-antitrypsin and CD 68 staining in the sarcomatous part of the tumor. Ultrastructural investigation confirmed the diagnosis. Multinucleated osteoclast type giant cells are probably of reactive origin.

Adult↗
PubMed1993

[Management of complications from endoscopic sphincterotomy].

Endoscopic sphincterotomy can replace operation. It was to be chosen in case of recurrence common bile duct calculi. The authors describe 11 complicated cases (2.01%) (9 women, 2 men) which demanded surgical management out of the 546 endoscopic sphincterotomy performed during 10 years (1982-1991). Operations were performed on 6 patients and 3 of them died (0.55%). Operation was necessary because of perforation and bleeding (2 perforations, 2 bleedings, 2 bleedings and perforations at the same time).

Aged↗
PubMedDate not supplied

Heterogeneous microcirculation in the rat small intestine during hemorrhagic shock: quantification of the effects of hypertonic-hyperoncotic resuscitation.

PURPOSE: In the event of a spatial or temporal microvascular perfusion heterogeneity conventional methods are often inadequate to describe the microcirculatory changes. Our aim was to use a new formula to characterize and compare the microcirculatory reactions in the mucosa and longitudinal muscle of the rat small intestine in response to hypertonic/hyperoncotic and normotonic resuscitation strategies. METHODS: Intravital videomicroscopy with an orthogonal polarization spectral (OPS) imaging technique was utilized. Microcirculatory variables were recorded during hemorrhagic shock (HS; 50 mm Hg mean arterial pressure for 60 min) and fluid replacement with 0.9% saline or with 7.2% saline containing 10% hydroxyethylstarch 200/0.5 (Osmohes; 4 ml/kg). Due to the temporal perfusion variability, microcirculatory changes were described using the calculation of the average red blood cell velocity (A-RBCV), while the spatial changes were calculated as a function of the size of the perfused capillary network. RESULTS: During HS and the late phase of resuscitation, perfusion was characterized by capillary flow motion (i.e. variability in time) in the villi, and by spatial flow heterogeneity in the longitudinal muscle layer. The approximately 40% decrease in the calculated villus A-RBCV during HS was only partially affected by 0.9% saline, whereas Osmohes completely restored A-RBCV by increasing both the red blood cell velocity and the duration of high-flow periods at the onset of resuscitation in the villi. The approximately 60% reduction in A-RBCV in the muscle layer during HS was not followed by an appreciable recovery in either group, but Osmohes significantly increased A-RBCV in the late resuscitation phase. CONCLUSIONS: The hypertonic/hyperoncotic solution induces a considerable microcirculatory improvement in two distinct layers of the small intestine after HS. This positive effect is related to the amelioration of the intestinal microcirculatory heterogeneity.

Animals↗
PubMedDate not supplied

Ultrastructural investigations of finger pulp biopsies: a study of 31 patients with Raynaud's syndrome.

Finger pulp biopsies of 31 patients suffering from Raynaud's syndrome (RS) were investigated by light and electron microscopy. The patients suffered from various underlying diseases. Interest was focused on the vascular changes and nerve and connective tissue alterations, especially the elastic fiber changes. In the dermal capillaries, endothelial swelling, narrowing of the lumen, increased numbers of intracytoplasmic filaments and Weibel-Palade bodies, and various types of basement membrane alterations were observed. The basement membrane of the unmyelinated nerves showed similar alterations to the capillary basement membrane. Severe degenerative changes were found in the myelin sheath of the myelinated axons. In the dermal connective tissue, severe elastotic degeneration and alterations of the collagen fibers were observed. The data probably represent the ultrastructural picture of the end stage of this syndrome.

Adult↗