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Biomedical subjects

K Velizarova

Publications and source records attributed to K Velizarova.

4 recordsLinked to original sources
PubMed1982

[Manifestations, treatment and prognosis in acute leukemia].

One hundred fifty one patients were studied--with acute lymphoblast leukosis (ALL) and acute non-lymphoblast (myelogenic) leukosis (ANLL). The disease had a fulminant course in 118 of the patients studied (21.8%). In 73 patients, out of 118 studied, no treatment effect was obtained (61.9%) and the rest 45 patients developed a complete remission (38.1%). In 10 of the patients with no treatment effect, a partial remission was obtained (8.4%). The remission is more frequent in case of ALL. The younger age, at present, remains the most essential prognostic factor. Partial initial leukose infiltration of the bone marrow was found in some of the patients. The bone marrow aplasia is not an obligatory phase of remission. The latter could develop by a gradual restoration of the normal hematopoiesis. The existence of stages with inducing of leukosis processes is possible that follow the reverse way in remission development. Hemorrhages are the most frequent complications in forms with fulminant course, and the infections--in the rest of the patients.

Adolescent↗
PubMed1974

[Pathologic neutrophilia in acute leukemia].

The morphological hemogram peculiarities are described in 10 patients with acute leukosis (nine with myeloblastoid variance and one with monocytoid variance of acute leukosis). Leukemic hiatus is not to be found in all the patients and besides paramyeloblasts--granular "filamented neutrophils" are present in the peripheral blood in considerable absolute values. Cytomorphologic, cytochemical and electron microscopic investigations were carried out on those "paraneutophils". Complex data for pathological leukosis characteristics of those cells were established that differed them from the normal cells. In five of the patients--definite data for acute leukosis were obtained with the histomorphological investigation of the blood tissue, in that way excluding primary myeloblast phase of myeloleukosis. Conclusions were drawn that those cells ("paraneutrophils") have the same prognostic value in peripheral blood as paramyeloblasts and are not affected by polychemical therapy. This was stressed to be a more particular variance of acute leukosis.

Adult↗