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Biomedical subjects

K Virsík

Publications and source records attributed to K Virsík.

At least 19 recordsLinked to original sources
PubMed1993

[Activity of the Department of Clinical Epidemiology during the 25 years of its existence in the clinical arena].

Twenty-five years ago in the Institute of Tuberculosis and Respiratory Diseases in Bratislava was created a Department of Clinical Epidemiology. It was the first department to bear this title. The authors analyze the activity of this department. They paid special attention not only to quantitative characteristics of the gained results, but also to the description of the used strategy in inserting clinical epidemiology into practice of institutions of therapy and prevention. After the lapse of 25 years the authors consider the establishment of the mentioned department as a correct decision which led to qualitative improvement and more effective activity of the Institute. (Ref. 8.)

Epidemiology↗
PubMed1983

Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral blood cells of patients with neoplastic diseases. I. Bronchogenic carcinoma.

By means of sensitive and specific radiochromatographic methods the activities of adenosine deaminase and purine nucleoside phosphorylase in peripheral blood cells of patients with bronchogenic carcinoma were estimated. It has been shown that purine nucleoside phosphorylase activity was two- to three-fold higher in lymphocytes of patients with epidermoid as well as other types of bronchogenic carcinoma in comparison with a group of healthy individuals. Adenosine deaminase activity in lymphocytes was elevated only in the group of patient with nonepidermoid carcinoma. The authors suggest that especially the estimation of purine phosphorylase activity in lymphocytes would be a useful laboratory test in the study of immune responsiveness of patients with bronchogenic carcinoma.

Adenosine Deaminase↗
PubMed1980

Combined treatment of patients with lung carcinoma. (Preliminary results assembled in international cooperative investigation).

The authors submit information on the preliminary results of combined treatment of patients with carcinoma of the lungs (epidermoid, adenocarcinoma, large-cell and combined carcinoma). The patients were classified, consistents with the protocol of the study, into two basic groups, each of which was sub-divided at random into two sub-groups. In the first group of 25 patients 9 were subjected to preoperative radiotherapy--2 000 rad (Co60) and 16 patients were operated without previous radiotherapy. The second group was formed by 41 patients incl. 21 who were treated by radical Co60 therapy and 20 patients who in addition to Co60 therapy were given the cytostatic preparation Methotrexate and 5-Florouracil. The submitted work is part of an international cooperative study within the framework of the Council of Mutual Economic Assistance which was started in 1976 and the enlistment of patients will be completed in 1980.

Adenocarcinoma↗