Changes in regional blood flow at late intervals after single and fractionated x-ray irradiation in rats.
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Biomedical subjects
Publications and source records attributed to K Volenec.
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In this study, the accuracy of Schottky diode sensors mounted as a two-dimensional array on a flexible 125 micro m thick polyester foil has been studied. The diodes are placed at a distance of 2.5 x 2.5 cm, resulting in a measuring area of 20 x 20 cm. The diodes are placed across the gap between both arms (3 x 5 mm) of a dipole, total length 12 mm. High resistance (1 M Omega/m) carbon transmission lines printed on the sheet are used to connect each electrical (E) field sensor to the read-out electronics and a data-acquisition system. It is demonstrated that the flexible Schottky diode sheet can quantitatively measure E-field distributions at 433 MHz with an overall accuracy of approximately 6% (1 SD). The largest contribution to the inaccuracy is related to the phantom heterogeneity. The absolute sensitivity of this electrical field sensor is 0.71 V/m per V/m of the applied external electromagnetic field. The DC-voltage signal of the diodes shows a more or less square root relation to the RF-power applied to the applicator over a 15-fold range. An important feature of the system is that it provides the ability to perform on-line monitoring of the E-field, i.e. the SAR distribution of 433 MHz applicators. Further, it enables the introduction of fast and easy quality control protocols for superficial hyperthermia applicators.
INTRODUCTION: Characterization of the performance of an hyperthermia applicator by phantom experiments is an essential aspect of quality assurance in hyperthermia. The objective of this study was to quantitatively characterize the energy distribution of the Sigma-60 applicator of the BSD2000 phased array system operated within the normal frequency range of 70-120 MHz. Additionally, the accuracy of the flexible Schottky diode sheet to measure E-field distributions was assessed. MATERIAL AND METHODS: The flexible Schottky diode sheet (SDS) consists of 64 diodes mounted on a flexible 125 microm thick polyester foil. The diodes are connected through high resistive wires to the electronic readout system. With the SDS E-field distributions were measured with a resolution of 2.5 x 2.5 cm in a cylindrical phantom, diameter of 26 cm and filled with saline water (2 g/l). The phantom was positioned symmetrically in the Sigma-60 applicator. RF-power was applied to the 4-channel applicator with increasing steps from 25W to a total output of 400 W. RESULTS: The complete system to measure the E-field distribution worked fine and reliably within the Sigma-60 applicator. The E-field distributions measured showed that the longitudinal length of the E-field distribution is more or less constant, e.g. 21-19 cm, over the frequency range of 70-120 MHz, respectively. As expected, the radial E-field distributions show a better focusing towards the centre of the phantom for higher frequencies, e.g. from 15.3-8.7 cm diameter for 70-120 MHz, respectively. The focusing target could be moved accurately from the left to the right side of the phantom. Further it was found that the sensitivity variation of nine diodes located at the centre of the phantom was very small, e.g. < 3% over the whole frequency range. CONCLUSION: The SAR distributions of the Sigma-60 applicator are in good agreement with theoretically expected values. The flexible Schottky diode sheet proves to be an excellent tool to make accurate, quantitative measurements of E-field distributions at low (25 W) and medium (400 W) power levels. An important feature of the SDS is that it enables one to significantly improve quantitative quality assurance procedures and to start quantitative comparisons of the performance of the different deep hyperthermia systems used by the various hyperthermia groups.
The parasitic thermovoltage can influence the temperature measurement during hyperthermia using the miniature multithermocouple probes with a common wire. It was noticed that, when a thermocouple junction is placed in a sharp thermal gradient, a parasitic thermovoltage is added to the voltage of all remaining thermocouples situated in the direction to the tip of the probe. This article gives the theoretical explanation, experimental verification, and practical elimination of this phenomenon.