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K W Chang

Publications and source records attributed to K W Chang.

60 records · Page 4Linked to original sources
PubMedDate not supplied

Alstrom syndrome with hepatic dysfunction: report of one case.

Alstrom syndrome is a rare autosomal recessive disorder associated with early childhood retinopathy, progressive sensorineural hearing loss, truncal obesity, and acanthosis nigricans. We report a 10-year-old boy with Alstrom syndrome presenting with general malaise and abnormal liver function for 1 year. In addition to the above mentioned features, he also had hyperglycemia and hyperinsulinemia. The mechanism responsible for the persistent elevation of liver enzymes could not be identified. To the best of our knowledge, this is the first-reported case of Alstrom syndrome with hepatic dysfunction in Taiwan.

Acanthosis Nigricans↗
PubMedDate not supplied

Menetrier's disease associated with cytomegalovirus infection in a child.

Menetrier's disease is a rare disease with unknown etiology characterized by protein-losing hypertrophic gastropathy and hypoproteinemia. We report on a 4-year-old boy who presented with a 2-week history of vomiting and periorbital edema. Upper gastrointestinal endoscopy revealed prominent gastric rugae, while pathological examination showed hyperplastic mucosa with proliferation, elongation, and basal cystic dilatation of the gastric glands replaced by mucous-secreting epithelium, confirming the diagnosis of Menetrier's disease. Virus isolation from urine revealed cytomegalovirus (CMV); and CMV immunoglobulin G and immunoglobulin M antibodies were detected in the serum. His condition gradually improved under omeprazole, with complete histological recovery after 3 months.

Anti-Ulcer Agents↗
PubMedDate not supplied

Activity of various endogenous compounds and pharmacologic agents at a glucose-oxidizing platinum electrode.

The specificity of a glucose-oxidizing platinum electrode system was investigated in vitro using selected metabolic compounds and a wide range of pharmacologic agents. Many compounds were found that either augmented or inhibited the glucose effect on the electrode system, but relatively few had substantial effects at reasonable plasma levels. Should the platinum electrode system be incorporated into an artificial beta cell for diabetic patients, graduated clinical trials might be necessary for every new medication taken by the patients.

Electrochemistry↗