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K W Lieberman

Publications and source records attributed to K W Lieberman.

9 recordsLinked to original sources
PubMed1987

Platelet MAO activity in geriatric patients with depression and dementia.

The authors studied platelet MAO activity in psychiatrically hospitalized geriatric patients with depression and dementia. Platelet MAO activity was higher in demented patients with and without depression and in depressed patients with reversible dementia than in nondemented depressed patients. The data suggest that abnormally high platelet MAO activity may reflect a predisposition to the development of a dementia syndrome.

Aged↗
PubMed1986

Aberrant parenting and delayed offspring development in rats exposed to lithium.

Natural lithium (Li) salts, including those used routinely in manic depressive illness, consist of two stable nonradioactive isotopes: lithium-7 (Li-7) (92.6%) and lithium-6 (Li-6) (7.4%). Female rats (3 months old) were treated with either Li-7 chloride or Li-6 chloride or were untreated prior to and during gestation and lactation. Birth weights were lower for Li-treated animals than for normal pups. Maternal behavior of all Li-treated mothers was altered. Li-7 mothers ignored their pups and nursed them infrequently. Li-6 mothers groomed and nursed their pups more often than normal mothers. All pups showed delays in development, especially in the maturation of depth perception. Although Li-6-treated dams were over-protective mothers, their offspring showed longer developmental delays than those of Li-7-treated offspring.

Animals↗
PubMed1985

Erythrocyte differentiation of naturally occurring isotopic lithium abundances.

Lithium is effective in the treatment of mania. There are two naturally occurring stable lithium isotopes, Li-7 (92.6%) and Li-6 (7.4%). Usually there is little differentiation between isotopes of an element, but chemical and behavioural data suggest dissimilarities exist between lithium isotopes. Results are now reported indicating that a group of manic patients given lithium chloride were able to differentiate Li-6 from Li-7 at the membrane level. Blood samples were drawn, erythrocytes separated from plasma and the isotopic abundances of Li-6 and Li-7 determined by atomic absorption spectrophotometry. The ratio of abundances of Li-6 in the erythrocyte and plasma was 1.274 indicating the erythrocyte membrane had the in vivo capability of isotope fractionation.

Adult↗
PubMed1979

Dissimilar effects of lithium isotopes on motility in rats.

Male Wistar rats were injected twice daily with chlorides of pure lithium isotopes, either Li-6 or Li-7. While both salts decreased mobility, the salt of Li-6 initially produced a more profound effect than the salt of Li-7. This differential effect of the isotopes proved to be time dependent and was most evident on the third day of treatment. Li-6 is likely to become a valuable tool in basic psychopharmacological research. It may possess therapeutic and/or toxic properties that are different from those of lithium salts currently used in treatment of mania.

Animals↗
PubMedDate not supplied

Lithium metabolism and intracellular electrolytes.

Lithium chloride was administered orally to swine and two different types of sheep, HK and LK. There was a pre-lithium 16-fold variation in intracellular sodium (LK greater than HK greater than swine) and a 6.5-fold variation in the intracellular potassium (swine greater than HK greater than LK). Collected plasma and erythrocytes were analyzed for lithium, sodium and potassium. The ratio of erythrocyte lithium/plasma lithium was directly related to the pre-lithium erythrocyte sodium concentration and inversely related to the pre-lithium erythrocyte potassium concentration.

Animals↗