[Biological side effects of potential antitubercular agents. I. The relationship between hepatotoxicity and the structure of thiobenzamides].
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Amides↗
Biomedical subjects
K Waisser
Publications and source records attributed to K Waisser.
[Antitubercular agents. XXIII. The effect of testing media on the evaluation of antitubercular activity of thiobenzamides in vitro].
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Amides↗
[Antitubercular agents. XXIV. Physical and physico-chemical properties of thiobenzamides. IV. The ultraviolet spectrum and its relation to antitubercular activity].
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Amides↗
[Antitubercular agents. XIX. Functional derivatives of 2-halogen-6-propylisonicotinic acid].
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Antitubercular Agents↗
[Antitubercular agents. XXII. Physical and physico-chemical properties of thiobenzamides. III. 13C-NMR spectra].
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Amides↗
[Antitubercular agents. XXI. Physical and physico-chemical properties of thiobenzamide. II. Protonization of the thioamide group].
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Amides↗
[Antituberculotics. 20. Pyridine quaternization as a model reaction for structure activity relationships of 6-halogen-2-alkyl-isonicotinic acid hydrazides].
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Antitubercular Agents↗
[Polarographic oxidation of phenothiazine substances in acetonitrile].
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Acetonitriles↗
[Use of vibration spectroscopy in the study of relationships between structure and biological activity of substances].
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Spectrum Analysis↗
[Estimation of the lipophility of phenols using separation thin layer chromatography. Comments on Biagi's method].
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Chromatography, Thin Layer↗
Chemical shift parameters of the methine proton in the NMR spectra of 4.4-diaryl-2.3-dihalogenoisocrotonic acids with antineoplastic activity.
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Antineoplastic Agents↗
[Antitubercular agents. XVIII. Physical properties of thiobenzamides. I].
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Antitubercular Agents↗
[Use of the HMO (Hückel's Molecular Orbitals) computations in the development and research of drugs].
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Computers↗
The application of Hückel molecular orbital calculations to study of antituberculotic activity of thioamides.
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Amides↗
[Antitubercular agents. XVII. Functional derivatives of 4-halogenpicolinic acid and its n-oxides].
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Antitubercular Agents↗
[Antitubercular agents. XVI. Use of HMO computations in the study of structure-activity relationship of antitubercular agents. III].
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Antitubercular Agents↗
[Antitubercular agents. XV. Use of HMO calculations in the study of structure-activity relationship of antitubercular agents. II].
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Antitubercular Agents↗
Quinazoline derivatives with antitubercular activity.
4-Quinazolinol was prepared by the reaction of anthranilic acid and formamide. The hydroxy group was converted into the thiol function by treatment with phosphorus(V)sulfide, and the subsequent alkylation of the thiol group was carried out with alkylhalides under the conditions of phase-transfer catalysis. The structure of the substances was confirmed by 1H, 13C NMR, IR, and MS. Most of the synthesized compounds exhibited antimycobacterial activity against the strains of Mycobacterium tuberculosis, Mycobacerium avium, Mycobacterium fortuitum, Mycobacterium kansasii and Mycobacterium intracellulare. 4-(S-Butylthio)quinazoline (3c) was even more active than isoniazide against atypical strains of mycobacteria.
Alkylation↗