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K Wesnes

Publications and source records attributed to K Wesnes.

57 records · Page 4Linked to original sources

Effects of smoking on rapid information processing performance.

In this paper two experiments are reported which were designed to investigate the effects of smoking on the performance of a rapid information processing task. The task involves the detection of sequences of three consecutive digits of the same parity from a series of digits presented visually at the rate of 100/min. In the first experiment smoking improved both the speed and accuracy of performance above rested baseline levels, the greatest improvement occurring with the highest nicotine and tar delivery cigarette. In the second experiment smoking again improved the speed and accuracy of performance above baseline levels, while performance deteriorated over time after not smoking as well as after smoking a nicotine-free cigarette. These findings demonstrate that smoking produces absolute improvements in performance and are explained in terms of the action of nicotine on central cholinergic pathways.

Adolescent↗

Quantification and characterization of fluctuating cognition in dementia with Lewy bodies and Alzheimer's disease.

Fluctuating cognition (FC) is a common and important symptom in dementia, particularly dementia with Lewy bodies (DLB), although it has not been empirically quantified or characterised. Forty subjects (15 DLB, 15 AD, 10 elderly controls) were evaluated using a clinical FC severity scale, as well as receiving measures of variability in attentional performance and slow EEG rhythms across 90 s, 1 h and 1 week. DLB patients had significantly more severe FC and more severe variability in attentional and slow electrocortical measures than either AD patients or normal controls in all time frames. Attentional and EEG variability also correlated significantly with independent clinical ratings of FC. Clinical quantification and measures of attention and EEG variability can therefore make an important and standardised contribution to the assessment of FC in dementia, facilitating future treatment studies with important implications for the potential causative mechanisms and differential diagnosis.

Aged↗