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Biomedical subjects

K Wiener

Publications and source records attributed to K Wiener.

At least 19 recordsLinked to original sources
PubMed1978

Anomalous behaviour of control sera in automated versions of the Kind and King alkaline phosphatase method.

Differences in alkaline phosphatase activity of some commerical control sera were observed when comparing manual with AutoAnalyzer versions of the Kind and King procedure. This phenomenon was found to be associated with sera boosted with exogenous alkaline phosphatase and to be owing mainly to inadequate provision of buffer in some automated methods. It is suggested that a modification to the SMA procedure may lessen the problem, but the constraints of the system necessitate a compromise. There was better precision after the modification had been introduced. Awareness of this phenomenon is of paramount importance if commerical sera are to be used in any way in the calibration of automated systems for alkaline phosphatase assay.

Alkaline Phosphatase↗
PubMed1977

Plasma cortisol, corticosterone and urea in acute myocardial infarction: clinical and biochemical correlations.

22 patients suffering from acute myocardial infarction were subjected to daily blood sampling for up to 6 days after admission to hospital. 5 patients with myocardial ischaemia and chest pain, but no evidence of infarction, were similarly investigated as controls. Daily measurements of plasma cortisol, corticosterone, cardiac enzymes and urea were performed. Plasma cortisol was elevated in all except one of the infarction cases and corticosterone was raised in 13 cases. Control patients had normal levels. Infarction patients were divided into three clinical groups: uncomplicated cases, complicated and fatalities. The latter group exhibited the highest levels of cortisol and corticosterone; no significant difference was seen between the other two groups. Uraemia tended to be associated with the complicated cases, particularly the fatalities, but not with uncomplicated cases. The three groups could be differentiated statistically on the basis of plasma urea concentration.

Acute Disease↗
PubMed1977

Plasma calcium in acute myocardial infarction.

Plasma calcium concentrations were measured in 18 patients suffering from acute myocardial infarction. Estimations were performed for several days after admission to hospital and a fall in plasma calcium was observed in 13 cases. Plasma albumin levels also decreased over this period, and correction of plasma calcium values to a fixed albumin level removed the apparent tendency to hypocalcaemia in these patients. Three patients with myocardial ischaemia showed similar decreases in plasma calcium and albumin. The observed changes are probably related to confinement to bed.

Calcium↗
PubMed1977

Paracetamol estimation: comparison of a quick colorimetric method with a standard spectrophotometric method.

A new colorimetric method for the estimation of plasma paracetamol was slightly modified and compared with a standard spectrophotometric method. Good correlation and no significant difference was found between results by the two procedures. Precision, accuracy, and recovery by the colorimetric method were acceptable. On the other hand it is less susceptible than the spectrophotometric method to interference by certain other drugs. The speed and simplicity of the colorimetric method, together with its satisfactory performance, make it a worthwile alternative to the spectrophotometric procedure.

Acetaminophen↗
PubMed1976

Uraemia and hyperuricaemia in acute myocardial infarction.

Plasma urate, urea and creatinine were measured at daily intervals for up to six days in 22 patients suffering from acute myocardial infarction. All except 3 patients showed some increase in plasma urea concentration and a tendency to increases in plasma urate was also observed. The increases in plasma urate correlated significantly with the increases in urea. This leads to the questioning of earlier reports linking hyperuricaemia with myocardial infarction when the possibility of uraemia has been ignored. Urine studies in a small number of patients showed no marked reduction in urea excretion, implying that increased production may partly account for the rise in plasma levels.

Acute Disease↗
PubMed1976

Infant's reaction to changes in orientation of figure and frame.

Five groups of five-month-old infants observed the same horizontal arrangement of a three-element stimulus placed in a rectangular frame during a series of habituating trials. These trials were followed by either (i) additional exposure to the familiarized standard, (ii) a tringular rearrangement of the three stimulus elements, (iii) oblique rotation of the three elements, (iv) oblique rotation of the three elements and the frame, or (v) oblique rotation of the frame alone. The infants were responsive to all changes in the spatial arrangement of the three elements and to the rotation of the frame, but were less responsive to the change in the frame. The two effects were not additive.

Cues↗