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Biomedical subjects

K Wink

Publications and source records attributed to K Wink.

At least 19 recordsLinked to original sources
PubMed2000

[Diagnosing magnesium deficiency. Current recommendations of the Society for Magnesium Research].

The cardiovascular risk increases with decreasing serum levels of magnesium, and this already at concentrations within the previous reference range (0.70-1.10 mmol/L). For this reason, the Society for Magnesium Research has updated its 1986 recommendations for the diagnosis of magnesium deficiency. The diagnosis is based on the patient's history, his clinical symptoms, and the results of clinical-chemical investigations of plasma/serum and urine. Further diagnostic methods used include the determination of ionized serum magnesium and the magnesium retention test. The optimal serum magnesium concentration is > 0.80 mmol/L.

Adolescent↗
PubMed1988

[Early hemodynamic cardiovascular reactions to nonionic low-osmolar contrast media in coronary angiography].

During the last 20 years there was an essential improvement in the tolerance of intravasal contrast media, leading to the nonionic low osmotic contrast media. In 26 consecutive patients with different stages of coronary heart disease the nonionic low osmolar contrast media iopamidol (Solutrast) and iopromide (Ultravist) were tested during coronary artery and left ventricular angiography. In both contrast media there were practically identically only slight early haemodynamic reactions with a decrease of heart rate, systolic pressure in the left ventricle, pressure in the aorta and an increase in pressure in the pulmonary artery and partly in cardiac output. These reactions are probably due to higher osmolality in comparison with blood. Therefore, further development of isotonic contrast media would be necessary.

Adult↗
PubMed1986

[Acute and delayed aortocoronary bypass operations following transluminal angioplasty].

Since 1980 348 PTCAs and 1288 CABs were performed at our institution (relation 1:4). In 15 cases (4.3%) emergency CAB was necessary because of complications encountered with PTCA. Two patients died, i.e. a mortality rate of 43.3% out of the emergency CABs or 0.6% out of the PTCA group; in 46.6% myocardial infarction occurred. In the same period 12 patients received CAB because of unsuccessful PTCA after a mean time of 4.6 months without increased operative morbidity. Interdisciplinary indication and experience, operation permanence and temporary coronary perfusion may decrease the complication rate.

Angioplasty, Balloon↗
PubMed1984

Acute and chronic effects of the beta-receptor blocker mepindolol on hemodynamics and the portal circulation.

After administration of mepindolol, a reduction of the portal pressure was demonstrated in an acute study in six patients with varying degrees of cirrhosis of the liver and in a chronic study in 5 patients. The reduction of the portal pressure did not correlate very closely with the decrease in the cardiac output. It is therefore assumed that a beta 2-receptor effect with dilatation of the splanchnic vessels is the main mechanism. However, further studies are required to clarify the situation unequivocally. The properties of mepindolol (intrinsic sympathomimetic activity, slight negatively inotropic effect, non-selective action, primarily renal elimination) appear to be advantageous in this respect.

Adult↗
PubMed1984

[Early hemodynamic reactions of an ionic low osmolar and a nonionic contrast medium].

In eighty patients with different cardiac diseases the theoretically claimed reduced cardiovascular side effects in ionic and non-ionic low osmolar contrast media compared to those in conventional ionic and high-osmolar contrast media were tested during heart catheterization. The randomized application showed that there were only few reactions during left ventricle angiography and they did not differ between various ejections, while during selective coronary angiography in most cases heart rate and aortic pressures dropped significantly (p less than 0.05). These alterations were significantly (p less than 0.05) stronger in the conventional ionic and high-osmolar ioxitalamat (Telebrix 350) than in the ionic and non-ionic low-osmolar ioxaglat (Hexabrix) or non-ionic low-osmolar iopamidol (Solutrast 370).

Adult↗
PubMed1984

Comparative clinical and hemodynamic investigations on two beta-receptor blocking agents (pindolol and mepindolol) in normal subjects.

Clinical and hemodynamic investigations of the effects of the new beta-receptor blocking agent mepindolol were compared with those of pindolol in studies with seven male subjects 23-34 years old. Mepindolol was found to be more effective in lowering the resting and exercise heart rate at lower dose levels. A more pronounced increase in right ventricular and pulmonary artery pressure was observed on exercise, but there was no difference between the two drugs in the effect on cardiac output. Thus mepindolol seems to have a greater effect on chronotropic than on inotropic receptors. This means that the drug can be given to patients with exertional angina without increasing the risk of cardiac decompensation.

Adult↗
PubMed1982

[Experimental and clinical investigations on reapplicability of resterilized intravascular catheters (author's transl)].

Catheters for cardiovascular and other angiographic investigations can be resterilized by ethyl-oxide. The procedure of sterilisation has to be controled permanently. Reapplicability of catheters has become quite common because of the high price of new catheters. In spite of optimal resterilisation and permanent controll some patients still get fever attacks, because endotoxins cannot be eliminated by this method.

Cardiac Catheterization↗
PubMed1981

[The influence of a beta-adrenergic receptor blocking drug and a calcium antagonist on heart function in normal subjects (author's transl)].

In 13 healthy volunteers, ergometric examinations in the supine position after intake of 2 x 40 mg/d (-)-1-(tert.-butyl-amino)-3-(o-cyclopentylphenoxy)-2-propanol (penbutolol, Betapressin), a new beta-adrenergic receptor blocking substance, or 3 x 60 mg/d N-(3,3-diphenylpropyl)-alpha-methyl-phenethylamine (prenylamine, Segontin) showed no alteration of the exercise tolerance compared to controls. Also there was a significant decrease of heart rate and systolic pressure and an increase of the maximal heart volume at rest and during exercise after intake of the beta-adrenergic receptor blocking drug. The increased heart volume decreased slightly during exercise as was observed in the controls. Diastolic blood pressure increased during exercise. After intake of the calcium antagonist prenylamine there was a slight decrease of heart rate and systolic pressure and an increase of the maximal heart volume. The increased heart volume decreased again during exercise as well as the diastolic pressure. Therefore the sparing of myocardial oxygen uptake can be explained by the decrease of heart rate and systolic pressure during beta-adrenergic blockade and during prenylamine because of an additional decreased afterload resulting from decreased diastolic pressure. Furthermore in the case of both drugs, the increased myocardial oxygen uptake caused by increased heart volume, will be decreased during exercise.

Adrenergic beta-Antagonists↗
PubMed1981

[Echocardiographic septal motion in 50 patients with coronary artery disease. A correlative study with coronary angiographic findings (author's transl)].

The literature about pathological septal motion in coronary artery disease is contradictory. Purpose of this study was to reveal the sensitivity and specificity of the echocardiography for diagnosis of stenoses and occlusions (S/O) of the left anterior descending artery (LAD). 50 patients with CAD were studied using coronary angiography and echocardiography. In 32 of the cases a critical stenosis (over 70% narrowing) of the LAD was present. History of old infarction was found in 80% of the patients. Angina pectoris was absent at the time of the investigation. It was proven that the sensitivity of the echocardiography for the diagnosis of coronary stenoses and for proximal and peripheral LAD-S/O is not high (44%-61%). 50 percent of all LAD-S/O and 61% of the proximal LAD-S/O have a pathological septal movement. In presence of a pathological septal motion, however, it may be concluded that there is a critical stenosis in one or more of the three main coronary arteries (predictive value 91%). The diagnosis of the localization of the occlusion by echocardiography is not possible. 1/3 of peripheral LAD-S/O also lead to a dyscinetic septum which mostly is found in proximal LAD-S/O. The number of false positive (pathological) echocardiographic septal dyscinetic motion is low (12%). The sensitivity of echocardiographic method for diagnose of coronary alteration is increased when using the differentiation between stenosis and occlusion of LAD. By that it can be revealed that full occlusions of the LAD lead in 80% to septal dyscinetic motion, whereas stenoses are only rarely combined with pathological septum (36%). It is concluded that not only the localization but predominantly the degree of the vessel-narrowing influences the septal movement. Perhaps these findings may help to declare the contradictory results in literature.

Adult↗
PubMed1980

[Prodromal symptoms of acute myocardial infarction (author's transl)].

Enquiry among 85 patients who had suffered myocardial infarction revealed prodromal symptoms in 69%, which consisted of a gradually developing angina in 28% and sudden severe thoracic pains in 31%. The localization of the pain in the prodrome coincided with that of the infarction in 82%. Prodromes occurred most frequently in patients with infarction of the anterior wall. Prodromal patients showed hyperlipidemia more frequently as a risk factor. Cardiac arrhythmias, cardiogenic shock, indications of incipient aneurysm of the heart wall and signs of heart failure were no less frequent in patients with and without prodromal symptoms. 42% of the patients sought medical attention because of the prodromal complaints. The therapeutic possibilities arising from this are discussed.

Adult↗
PubMed1980

Cytomegalovirus myocarditis.

A male patient, aged 31 years, with a cytomegalovirus (CMV) myocarditis is described, who showed a high IgM antibody titer for cytomegalovirus infection of 1:1,024 and a rise of the titer for complement-fixing antibody from 1:< 16 to 1:256. CMV could be isolated from the urine. Investigations for other etiological factors were negative, and we assumed a connection between the cytomegalovirus infection and the myocardial involvement.

Adult↗