Proceedings: Pharmacokinetics of digitalis glycosides with an altered lactone ring in humans.
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Biomedical subjects
Publications and source records attributed to K Wirth.
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A report is given about a 53 years old man with a "stagnant loop syndrome" associated with a diverticulosis of the whole small intestine and colon. Steatorrhoea was the main clinical symptom. The classification, distribution and frequency of intestinal diverticulosis is based on radiological results. The pathological values of the absorption tests prompted for a discussion of new examinations in the "stagnant loop syndrome". The property of the intestinal bacteria to influence the absorption of fat, xylose and vitamin B12 is stressed. Finally the possible methods of treating the diverticulosis with "stagnant loop syndrome" are discussed.
3H-alpha-Acetyl-digitoxin was administered to 5 patients i.v. and 3 patients p.o. The half-life of label in the plasma was 8.5 +/- 1 (i.v.) and 8.8 +/- 1 (p.o.) days. 20.9 +/- 3.6% (i.v.) and 21.3 +/- 2.9% (p.o.) of the radioactive dose were excreted into the urine in 6 days. Two patients excreted within 18 days 14.3 and 16.1% of the given dose with the stool. After oral administration 22.3% of the orally administered 3H-activity were eliminated into the feces by one patient. 63% (i.v.) and 53% (p.o.) of the chlorofrom-extracted 3H-activity in the urine could be attributed to digitoxin by means of thin-layer chromatography. The volatile content of plasma radioactivity was 4.07 +/- 0.1% (i.v.) and 6.78 +/- 0.2% (p.o.). The protein binding of a 4%. Albumin solution was 83 +/- 0.54%, for plasma 80.8 +/- 2%.
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