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Biomedical subjects

K Wiseman

Publications and source records attributed to K Wiseman.

7 recordsLinked to original sources
PubMed2000

Motor cortex excitability in patients with migraine with aura and hemiplegic migraine.

We studied the excitability of the motor cortex using transcranial magnetic stimulation (TMS) in 12 patients with migraine with aura (MA) and nine patients with familial hemiplegic migraine (FHM). Motor thresholds at rest, the duration of the cortical and peripheral silent period and intracortical inhibition and facilitation using paired-pulse TMS at intervals of 2 to 15 ms were measured with patients free of attacks for at least 48 h. In contrast to previous reports we could not find any significant differences between patient groups and compared to controls (n=17) in the parameters tested. The results suggest that there are no interictal changes of excitability of the motor cortex in migraine. This study does not support the concept of general cortical hyperexcitability in migraine secondary to a genetic predisposition or a structural alteration of inhibitory interneurones in the cortex due to repeated parenchymal insults during attacks.

Adult↗
PubMed1987

Alprazolam, diazepam, imipramine, and placebo in outpatients with major depression.

Two hundred forty-one outpatients with a DSM-III diagnosis of major depressive disorder participated in a six-week double-blind therapeutic trial of alprazolam, diazepam, imipramine hydrochloride, and placebo. Side effects were given as a major reason for attrition by patients taking the three active compounds and ineffectiveness was the reason given by patients taking placebo. Imipramine-treated patients reported the most and placebo patients the least number of adverse effects. Imipramine and alprazolam, but not diazepam, produced significantly more improvement in depressed symptomatology than did placebo. Mean diazepam scores frequently assumed an intermediate position between those of imipramine or alprazolam and placebo. These treatment differences were found to be independent of initial severity levels of anxiety and depression.

Adult↗
PubMed1981

Clobazam and diazepam in anxiety.

The anxiolytic effects of clobazam, diazepam, and placebo were compared in a 4-wk double-blind study of 159 anxious outpatients, primarily from family practice. Clobazam (30 to 80 mg/day) and diazepam (15 to 40 mg/day) were found to induce similar side effect, primarily sedation, and although both active drugs induced greater clinical improvement than placebo, clobazam induced the largest degree of improvement in most aspects. It was speculated that the relatively high daily dosage of diazepam may have been contributed to these results.

Adult↗