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Biomedical subjects

K Work

Publications and source records attributed to K Work.

At least 19 recordsLinked to original sources
PubMed1991

Sodium hyaluronate and methylcellulose in extracapsular cataract extraction. A controlled study of the intraocular inflammation following the peroperative use of sodium hyaluronate and methylcellulose.

In a controlled prospective trial the peroperative use of sodium hyaluronate and methylcellulose (2%) was compared. Two hundred and fifteen patients received sodium hyaluronate and 189 methylcellulose during extracapsular cataract extraction. We found no significant difference in postoperative anterior chamber inflammation, intraocular pressure, frequency of fibrin in the anterior chamber, nor need for additional medication during the first 5 postoperative days.

Aged↗
PubMed1990

Retinal nerve fibre layer photography in glaucomatous and normal eyes.

The technique of retinal nerve fibre photography has been developed and tested in specialized centres and glaucoma clinics. The usefulness of a modified technique in clinical practice is the subject of this prospective study. Retinal nerve fibre photos from 41 patients with open-angle glaucoma and 40 normal patients were examined in a blind study, a total of 161 eyes. Photos from 5 eyes were of insufficient quality to allow evaluation. Nerve fibre loss was found in 36% of the normal eyes, 42% of glaucomatous eyes without visual field defects, and 87% of eyes with glaucomatous visual field defects. Sensitivity was 86% and specificity was 62% totally. In the younger patients aged less than 65 years both values were 82%. Photographic nerve fibre loss was found in 69% of normal eyes from patients aged more than 65 years, leading to a low specificity of 31% in this age group. Age related nerve fibre loss and clinically insignificant cataracts were the most obvious causes of non-glaucomatous nerve fibre loss.

Adult↗
PubMed1990

Retinal nerve fiber layer in multiple sclerosis.

To evaluate the usefulness of the retinal nerve fiber layer (RNFL) appearance in estimation of optic nerve damage in MS, we examined 20 patients with definite MS and 20 normal control patients. Photographs of the RNFL in 80 eyes were classified as normal or abnormal by two examiners working independently. The results were very similar, even though the clinical data of which they were informed and their experience with RNFL-evaluation differed. We found RNFL defects in 80% of MS patients and in 73% of MS eyes. In the control group the values were 5% and 2.5%. Subclinical optic neuropathy in eyes without any history of optic neuritis was demonstrated by RNFL defects in 68%. We conclude, that in detecting clinical and subclinical optic neuropathy, RNFL-evaluation is to be recommended as the method of choice.

Adult↗
PubMed1990

Automated static perimetry and nerve fibre layer defects in glaucoma and controls.

Correlation of psychophysical tests and structural changes is essential in the management of glaucoma. We compared the mean sensitivity and the short-term fluctuation in eyes with and without defects in the retinal nerve fibre layer in 41 glaucoma patients and 40 controls. In the glaucoma group 87.2% of eyes with visual field defects and 42.3% without visual field defects showed nerve fibre loss. In the control group 36.3% showed nerve fibre loss. In manifest glaucoma the mean sensitivity was 10.9 +/- 7.2 dB in eyes with nerve fibre loss and 19.2 +/- 3.9 dB in eyes without nerve fibre loss. This difference was statistically significant. The corresponding difference in glaucoma suspects and controls was not statistically significant. There was no difference between the short-term fluctuation in the three groups regardless of nerve fibre loss.

Aged↗
PubMed1990

The effect of learning and age on short-term fluctuation and mean sensitivity of automated static perimetry.

Knowledge of the effect of perimetric experience is essential in evaluation of visual fields. In the present study we report on the learning effect on short-term fluctuation (SF), and mean sensitivity (MS) correlating this effect with age in the older age groups. A sample of 33 volunteers with no history of ocular disease was subjected to two automated static perimetry tests. Program 32 of the Octopus 2000 was used for evaluation of the learning effect on SF and MS of the whole field, single quadrants and three eccentric zones. The learning effect on MS of the whole field and single zones of the first and the second session was statistically significant except in the upper temporal zone. Further, the learning effect showed a positive correlation with age on MS of the whole field, the lower quadrants and the eccentric zones from 0 to 20 degrees. The SF showed a significant learning effect, but no correlation with age could be demonstrated. However, SF increased significantly with age.

Aged↗
PubMed1970

Coccidian-like nature of Toxoplasma gondii.

Specific pathogen-free domestic cats were fed with tissue cysts containing Toxoplasma gondii. In two infected cats large numbers of oocysts were produced in the faeces; no oocysts were observed in the faeces of the uninfected control cat. Five days after the feeding of the toxoplasms profuse schizogonic and gametogonic stages were observed in the epithelial cells of the small intestine of one infected cat. A single schizont was observed in an intestinal epithelial cell of a second cat six days after being fed the tissue cysts. There was no evidence of schizogony or gametogony in the uninfected control cat. The stages observed in the intestinal epithelium are identical with those of the well-known endogenous cycles of coccidian parasites. The appearance of these stages, together with the nature of the oocyst, indicates that T. gondii is a coccidian parasite closely related to the genus Isospora.

Animals↗