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Biomedical subjects

K Zhuber

Publications and source records attributed to K Zhuber.

11 recordsLinked to original sources
PubMed1977

[A metal-ceramic composite endoprosthesis for total hip replacement (author's transl)].

A total hip endoprosthesis of our own conception is described. The implantation is done partially without bone cement. The socket and the head are made of alumina whereas the femoral component is of metal. Bone cement is used only for implantation of the shaft. 17 patients on whom operations were performed more than 6 months previously were followed up. The preliminary results are satisfactory. In particular, there were no signs of loosening of the socket. Therefore, this prosthesis is considered to be one step towards a total hip endoprothesis for implantation without bone cement.

Aluminum Oxide↗
PubMed1976

[Treatment and prognosis of osteosarcoma in childhood (author's transl)].

126 osteosarcoma under the age of 15 years are followed up in an interclinical study. There is a steady increase of tumor incidence towards the 15th year with a slight male preponderance. The main sites of the tumor are the distal femur followed by the proximal tibia and humerus. Evidence of multiple metastases is most often present in the lungs, less often in the skeleton. Nearly always metastases became evident within 2 1/2 years after diagnosis (98%). Therefore the 2 1/2-year disease--free survival rate seems to be sufficient for prognostic evaluation. The over all 2 1/2-year survival rate was 17,5%. Though the different methods of treatment are not statistically valid, the best results can be expected after early amputation. By radiotherapy alone no cure has been achieved. Survivals were seen at any age and at any site of long bones (distal femur, proximal tibia, humerus, femur, distal radius). Prognosis of osteosarcoma in the childhood is similar to that of the adult group.

Adolescent↗
PubMed1975

Osteosarcoma in children. A study of 125 cases.

A study is presented of the aetiology and results of treatment in a group of 125 proven osteosarcomas present in children under fifteen years of age. These cases have been collected from the records of one English and six European treatment centres. There is a slight male preponderance, but the striking aetiological feature is the very high proportion of tumours of the long bones of the limbs (96 per cent). The two and a half and five year disease-free survival rates were respectively 15 and 12 per cent, with a further 9 per cent still living, but under observation for less than two and a half years. Evidence of metastasis after two and a half years is very unusual, but no child with a tumour of an axial or girdle bone lived this length of time. Although the differences in the results of the different methods of treatment employed are not statistically valid, the largest number of long survivors had been treated by early amputation, which method also provided the lowest rate of local tumour recurrences. Reasons are discussed which indicate that prompt ablation is the treatment of choice, perhaps with certain advantages in the light of recent advances in adjuvant treatment. The past situation in connection with childhood osteosarcoma certainly provides strong support for immediate carefully designed clinical trials of the new adjuvant methods cited.

Age Factors↗