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Biomedical subjects

K Zielińska

Publications and source records attributed to K Zielińska.

At least 19 recordsLinked to original sources

Guaianolides from Cichorium intybus and structure revision of Cichorium sesquiterpene lactones.

The isolation and structure elucidation of a new lactucopicrin derivative from Cichorium intybus is described, together with the revised structures of several sesquiterpene lactones previously isolated from Cichorium species. The known eudesmanolide magnolialide and the known guaianolide ixerisoside D, reported for the first time from the plant material, along with the previously known chicory sesquiterpene lactones have been also isolated and identified.

Cichorium intybus↗

Sesquiterpenoids and phenolics from Crepis mollis.

From the roots of Crepis mollis, one new and two known guaianolides were isolated together with eight known guaianolide glycosides, one known germacranolide glycoside and two known phenylpropanoids. The structure and relative configuration of the new compound were established as 9alpha-hydroxy-4beta, 15, 11beta, 13-tetrahydro-dehydrozaluzanin C by spectral methods.

Asteraceae↗

[Urinary tract infections in newborns].

The retrospective analysis had been performed on 3480 newborns weighted more than 1001 g, over the period of thirty one months. There was evaluated the frequency (1.25%), and clinical manifestation of the disease in newborns. Male and full term infants suffered from the disease more frequently then other evaluated infants. About half of cases were asymptomatic in the beginning of disease, and in the majority part of them, course of illness were non-characteristic. There was observed generalised oedema and swellings, irritability, intensive jaundice, dehydration, fever and poor peripheral perfusion. Laboratory findings manifested: anemia, hypoglycemia, higher WBC, metabolic acidosis, and especially hyperbilirubinemia, and in urine: pyuria and proteinuria mainly. In most cases of the disease urea and creatinine level in the serum were normal. The most dominant pathogenic agent was E. coli (above 72%).

Escherichia coli↗

[Complications during the neonatal period in newborns of adolescent mothers].

In 1990-1992 64 female and male newborns born by adolescent mothers were examined in Obstetrics Clinic of Pomeranian Medical Academy in Szczecin. There were analysed such factors as sex, gestational age, birth weight, clinical condition of newborns after birth, Apgar scores, frequency of perinatal trauma. It was observed that the percentage of prematurity, complications in neonatal adaptation, perinatal trauma and infections were significantly higher in the examined group. It was found that newborns from adolescent mothers formed a high risk group with neonatal complications. In consequence a great number of disorders can be expected in the postnatal development of newborns.

Adolescent↗

Econometric analysis of phase duration for blood morphology and basophil count alterations in chronic granulocytic leukaemia.

The retrospective analysis of 40 cases with chronic granulocytic leukemia revealed an average survival time of 39 months. Modal proportions between the chronic, accelerated and acute blastic crisis amounted to 25:6:8 months. The characteristic points and curves for peripheral white cell, blast cell, basophil cell and thrombocyte counts as well as haemoglobin levels were determined separately in 20 patients with long and in 20 with short survival time. Comparisons indicate among others that Busulphan sensitivity is an essential factor for a longer survival time of CGL patients.

Adolescent↗

25-hydroxyvitamin D in patients with essential hypertension.

Plasma 25-OH-D levels of normotensive and hypertensive subjects living in a highly industrial and in a nonindustrial area, were estimated. Significantly higher values were found in normotensive subjects than in hypertensive patients. Severity of arterial hypertension was not related to plasma 25-OH-D. Both groups of subjects (normotensive and hypertensive) living in the industrial area with high air pollution had lower 25-OH-D concentrations than those living in the nonindustrial region. Data presented in this paper suggest that antihypertensive treatment by pharmacologic agents exerts a depressive effect on plasma 25-OH-D level.

25-Hydroxyvitamin D 2↗