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Biomedical subjects

K Ziesenhenn

Publications and source records attributed to K Ziesenhenn.

17 recordsLinked to original sources
PubMed1990

[Isovolemic hemodilution--an adjuvant treatment principle in patients with chronic cor pulmonale caused by chronic obstructive lung disease].

On the basis of 10 patients with chronic cor pulmonale due to chronic obstructive lung disease and secondary polyglobulia in a clinical and experimental study could be made evident that by limited isovolaemic haemodilution (haematocrit value of 0.58 +/- 0.03 reduced to 0.36 +/- 0.01) are to be expected a decrease of the total pulmonary-arterial resistance, a reduction of the mean pulmonary arterial pressure, an increase of the partial O2-pressure as well as an increase of the heart index. Analogically to this as a consequence of the improved rheologic conditions a clear involution of the clinical signs of a heart insufficiency developed. Complications were not observed. The technique of the limited haemodilution should find a broader use in the medical practice, taking into consideration the isovolaemia as adjuvant treatment principle for patients with the indication mentioned.

Blood Volume↗
PubMed1990

[Routine diagnosis in patients with latent sinus node syndrome].

The establishment of latent disturbances of the sinus node function is with high security successful by the determination of the sinus node recovery time only after medicamentous provocation with propranolol/atropin and verapamil, since the sensitivity of the determination of the sinus node recovery time is to small in the up to now usual way and in normal findings it is not able to exclude a sinus node dysfunction. The course of the investigation could be optimized according to the fact that despite complete medicamentous provocation only one running through stimulation is necessary without an endangering of the patient being the results. By this means of 75 patients 32 patients (43%) could be identified as sinus node syndrome of different degree of severity. On the basis of the improved ability of statement the determination of the sinus node recovery time for the diagnostics in patients with unclear syncopes and inconspicuous findings of the ECG should be performed only after a combined medicamentous provocation.

Aged↗
PubMed1979

[Bicycle ergometric testing in the acute phase of liver disease with particular reference to changes in serum enzymes].

It is reported on 20 patients (17 women, 3 men) who had undergone a bicycle-ergometric load in the acute phase of virus hepatitis (an average at the 16th day after admission to hospital). Among the significant changes of the activity the slight increase of SGPT 30 minutes after the end of the load as well as the clear decrease of the enzyme activities of SGPT and SGOT below the initial value 48 hours after load are particularly to be emphasized. LDH and CPK exhibited only insignificant changes of activity. It remains open to what extent there exists a connection between the ECG-changes proved in about half the women and the virus hepatitis as a cyclic infectious disease. In the 20 patients examined a clinically recognizable deterioration in the course of the disease by the load examination did not appear.

Acute Disease↗
PubMed1978

[Optimization of therapy using cardiac glycosides].

By the estimation of the serum glycoside concentration during the last years numerous new recognitions have been got, particularly concerning the pharmacokinetics of the heart glycosides, which increasingly will be reflected in the clinical practice. Apart from thoughts on pharmacokinetics the author adopts a definite attitude to glycoside tolerance, to the influence of age and bodyweight as well as to the importance of disturbances of the renal function. Moreover it is referred to new aspects in the dosage of heart glycosides, in which case the revision of the central therapy recommendations seems to be necessary.

Adult↗
PubMed1978

[Does abdoman cause ileus?].

On account of its favourable pharmacological properties Abdoman has proved in the treatment of patients with uncomplicated duodenal ulcer. On the basis of its pronounced motility inhibiting effect on the gastrointestinal canal it may be additionally used for the treatment of diarrhoea. It is reported on 5 patients in which under Abdoman therapy a paralytic ileus developed as severe complication, so that it must be warned of an uncontrolled prescription of abdoman concerning this indication. Abdoman should be used above all in juvenile patients, in which case particular attention must be paid to obstipation as most frequent side-effect.

Aged↗
PubMed1978

[Evaluation of the clinical severity in occlusion of the superficial femoral artery].

The judgment of the efficiency of the collateral circulation is of decisive importance for the estimation of the clinical degree of severity and thus also for the indication to angiosurgical measures. Since also angiographically only an indirect evidence concerning the collateral circulation can be given, the angiological findings of 18 patients with unilateral or bilateral occlusion of the superficial femoral artery (n = 25 lower extremities) were evaluated. On the basis of the measuring values received with the help of the phebembraxis plethysmography 3 degrees of severity may be differed which essentially correspond to clinical stage: 1. good collateral circulation (data in ml/100 ml tissue min: ff above 5 ml, pf above 15 ml, pf-time below 30 s 2. moderate collateral circulation: ff below 5 ml, pf below 15 ml, pf-time 30-60 s 3. bad collateral circulation: ff below 5 ml, pf below 10 ml, pf-time above 60 s. Of the measuring sizes (ff, pf, pf-time) the pf-time proved to be the most reliable parameter. On the basis of these results the phlebembraxis plethysmography is a valuble supplementation in the preoperative vascular diagnostics.

Arterial Occlusive Diseases↗
PubMed1978

[Physical capacity of patients with liver diseases as well as its significance for therapy and evaluation].

In 50 patients with different liver diseases (20 with subsided viral hepatitis and 30 with degenerative liver damages) the serum enzyme course of SGOT, SGPT, LDH and CPK was investigated after ergometer load. The enzymes were estimated before as well as 1/2, 2, 4, 24, and 48 hours after load. 48 hours after load additionally the liver biopsy after Menghini was carried out. According to the histological findings the 20 patients with viral hepatitis were subdivided into 13 with still active and 7 with residual hepatitis as well as the 30 patients with degenerative liver damages into 15 with toxical hepatosis, 6 with fatty degeneration of the liver cells and 9 with signs of metabolic activation. Since the significant increases of enzymes could not be proved in any of the fours enzymes 1/2 to 48 hours after load we are of the opinion that the liver, independent on the kind of the lesion, better tolerates physical work. Moreover, it seems that load investigations under ergometry with estimation of the course of the serum enzymes are unsuited for the judgment of the degree of activity and the degree of cure of liver diseases, respectively.

Adult↗
PubMed1978

[Incidence of toxic liver lesions due to Gravistat].

In 200 women who on the average 5.6 years took ovosiston and/or non-ovlon, and in 40 women who during the last three months had not taken an oral contraceptive we determined the GOT, the GPT, and LP-X and the cholesterol in the serum before and after a three weeks intake of gravistat. After a three weeks intake of gravistat of the two groups ca. one fourth showed pathological transaminases. 30 women with pathological transaminases and/or positive LP-X were hepatologically investigated including liver biopsy after an on an average 7.3 weeks exposition of gravistat. In ca. one third of the cases histologically provable changes of the liver (toxic hepatosis, fatty liver, infectious hepatitis) and in ca. two thirds of the cases the picture of the metabolic activation were found. Morphologically no signs of an intrahepatic cholostasis could be proved, so that it does not seem to be the leading parameter of the toxic liver damage.

Chemical and Drug Induced Liver Injury↗
PubMed1977

[Toxic hepatoses due to Gravistat].

With the help of 5 cases with toxic hepatosis by administration of Gravistat the problems concerning ovulation inhibitor and toxic hepatosis were explained. The clinical, paraclinical and histological findings may be pronounced differently. Anamnestically in prescribing ovulation inhibitors particularly a jaundice during pregnancy or a pronounced pruritus in the 3rd trimester of the pregnancy must be taken into consideration. Toxic liver damage may appear not only when the ovulation inhibitor is given the first time, but also after changing it. For this reasons idiopathic jaundice during pregnancy and condition after toxic hepatosis by ovulation inhibitor in every case must be regarded as contraindications for the application of oral contraceptives. In order to establish subclinical courses a control of transaminases in the first three cycles of using the remedies is to be demanded.

Adult↗
PubMed1977

[Results of stationary management of patients with hypertension with reference to previous ambulatory care].

The case histories of 100 patients who were hospitalised in the Department of Internal Medicine of St. George's Hospital in the period from January 1975 to March 1976 are analysed mainly to study their treatment as outpatients (information of the patient, previous diagnoses and treatment, and diagnosis at the time of hospitalisation) and the results of their in-hospital treatment. Most of the patients were admitted to hospital at an advanced stage, usually when out-patient treatment had failed to produce results, but in 80% of the cases the result of in-hospital treatment was satisfactory or good. Besides improvement in drug combination and treatment of cardiac insufficiency, the most frequent complication, observation of general therapeutic principles under conditions of in-hospital treatment was found to be of special importance. Over and above this, we regard close cooperation of hospital and out-patient clinic as essential in the optimisation of the treatment of hypertension.

Adolescent↗
PubMed1977

[Comparative studies on the value of oscillography and venous occlusion plethysmography in the diagnosis of arterial occlusive diseases].

Oscillography and plethysmography in phlebembraxis also occupy an important place in the screening of arterial obstructive diseases. The two methods give reliable results. In patients who have--as was established by oscillography and clinical examination--healthy vessels, as well as in patients with arterial obstructive disease in stage II a good correspondence with the findings of plethysmography in phlebembraxis could be proved, if all the three measuring sizes (first flow, peak flow and peak flow time) were taken into consideration. Hereby the normal values given partly deviate from those ones given in literature. They are guide values which in the individual case may fall below or transgressed also in patients with healthy vessels, whereby the peak flow time is to be regarded as the most reliable measuring size. On account of the slight expenditure of time the plethysmography in phlebembraxis is suitable as screening method, however it is not sufficient as the only method for the angiological prediagnostics. It is a valuable supplementation to the hitherto known unbloody examination methods.

Angiography↗
PubMed1977

[Hemodynamics in chronic cor pulmonale during exercise (author's transl)].

1. In patients with chronic cor pulmonale there is a regression dependence between the amount of exercise-induced increase in pulmonary arterial pressure and the level of resting value. 2. Hemodynamics during exercise are influenced by the patient's position in a certain degree. 3. The exercise-induced increase in pulmonary arterial pressure in chronic cor pulmonale is not influenced by the patient's age. 4. The time course of pressure fall during recovery depends on the amount of pressure increase during exercise, it depends less evidently on the level of the resting values. 5. Tachycardia is not a compulsory symptom of chronic cor pulmonale.

Blood Pressure↗
PubMed1976

[Importance of ECG in the monitoring of patients with pacemakers].

As treatment method of choice in permanent bradycardic disturbances of cardiac rhythm the control of pacemaker patients increasingly obtained importance. The knowledge of the normal as well as the disturbed pacemaker ECG is one condition for the optimal care of pacemaker patients, since more and more practicing physicians are involved into this responsible activity. After description of the ECG in intact pacemaker function (including the possibilities of errors) the disturbances most frequently observed in practice (change of the pacemaker frequency, deficits of synchronisation and stimulation) are dealt with and explained.

Bradycardia↗
PubMed1976

[Clinical symptoms and differential diagnosis of acute arterial vascular occlusion in the limbs].

The acute arterial vascular occlusion is relatively rare, but without any exception it belongs to the medical emergency situations. The early diagnosing is decisive, since embolectomy is to be regarded as method of choice during the first 10 hours. After demonstration of the most frequent sources of embolism and their clinical manifestation symptomatology and most essential differential diagnoses of the acute arterial vascular occlusion are discussed. As consequence for practice must be demanded that at the least supposition on the presence of an acute arterial vascular occlusion the immediate hospitalisation is necessary.

Acute Disease↗
PubMed1975

[71. Float catheter and pulmonary work load hypertension in mitral valve defects and cor pulmonale].

In patients with mitral valvular defects as well as with chronic cor pulmonale there exists an ascertained relation between the pulmonary-arterial pressure in rest and the increase of blood pressure under easy physical load. Patients with high initial value or strong increase of blood pressure reveal a retarded return of the blood pressure of the pulmonary artery to the initial value.

Adult↗
PubMed1975

[Frequent errors in ECG registration].

The correct ECG-registration is the basic prerequisite for a certain ECG-diagnostics. If certain mistakes in registration are not taken into consideration diagnostic errors attended with grave consequences are possible. The disturbances most frequently observed in practice (disturbances on the patient's part, errors in working, technical disturbances) are described and explained.

Diagnostic Errors↗