Biomedical subjects
K von Berlepsch
Publications and source records attributed to K von Berlepsch.
Fingertip temperature as an indicator for sympathetic responses.
Changes of acral skin blood flow are a commonly used indicator for sympathetic reflex responses to various stimuli. The goal of the present study was to determine whether decreases in fingertip temperature are indicative for sympathetic induced changes in microcirculation. Infrared thermography demonstrated that various stimuli triggering the sympathetic nervous system induced decreases in cutaneous microcirculation, most prominently in fingertip skin. Various such stimuli induced almost immediate temporary vasoconstriction, measured by laser Doppler flux and photoplethysmography. With a lag phase of approximately 15 s, reduced microcirculation was also reflected by a transient decrease in fingertip temperature. Vasoconstrictions were easily demonstrable by fingertip temperature when the starting fingertip temperature was above 32 degrees C and vasoconstriction lasted at least 5 s. Temperature measurement offers the advantages of ease and simplicity of performance and analysis, compared with the more complex analyses of flux and pulse volume.
Drugs from marine organisms: the target of the Roche Research Institute of Marine Pharmacology in Australia.
A modern approach to the search for biologically active substances of potential therapeutic use isolated from marine organisms is illustrated by a presentation of the multidisciplinary project pursued by the Roche Research Institute of Marine Pharmacology near Sydney, Australia. This specialized institute is part of the world-wide research endeavour of our company and has now been in operation for five years. Following a brief outline of the technical functions the main scientific achievements published by the scientists of the institute are reviewed. This institute is, to our knowledge, the only one of its kind in private industry and we have attempted to demonstrate how its activities should be viewed in the overall context of today's drug or product development.
Two automated procedures for determination of uronic acid in acid glycosaminoglycans.
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Acid mucopolysaccharides after overdilatation of the aortic wall of the rabbit.
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