PubMed Health⌕ Search

Biomedical subjects

KW Lee

Publications and source records attributed to KW Lee.

7 recordsLinked to original sources
PubMed2001

Asymptotic Particle Size Distributions Attained during Coagulation Processes.

The effects of the collision kernel on the self-preserving size distribution and on the gelation phenomenon of aerosol coagulation were investigated. An analytical solution for the asymptotic width of log-normally preserving size distribution during coagulation was obtained as a function of the degree of homogeneity using arbitrary shape of homogeneous collision kernels. From the solution obtained, it was shown that when the degree of homogeneity is larger than 1, self-preserving size distribution does not exist, and gelation occurs. A very accurate numerical coagulation simulation method, the sectional method, was also used for calculating the self-preserving particle size distribution for some specific classes of coagulation kernels and the results were compared with the analytical solution obtained by the log-normal method. Copyright 2001 Academic Press.

Journal Article↗
PubMed2000

Brownian Coagulation of Fractal Agglomerates: Analytical Solution Using the Log-Normal Size Distribution Assumption.

An analytical solution to Brownian coagulation of fractal agglomerates in the continuum regime that provides time evolution of the particle size distribution is presented. The theoretical analysis is based on representation of the size distribution of coagulating agglomerates with a time-dependent log-normal size distribution function and employs the method of moments together with suitable simplifications. The results are found in the form that extends the spherical particle solution previously obtained by K. W. Lee (J. Colloid Interface Sci. 92, 315-325 (1983)). The results show that the mass fractal dimension has a significant effect on the size distribution evolution during coagulation. When the obtained solution was compared with numerical results, good agreement was found. The self-preserving size distribution of nonspherical agglomerates is discussed. Copyright 2000 Academic Press.

Journal Article↗
PubMed1999

Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) - genetic predisposition and metabolic abnormalities.

Non-insulin-dependent diabetes mellitus (NIDDM), also known as type II diabetes, is characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with microvascular, macrovascular, and neuropathic complications. NIDDM is a complex disease with many causes. Both genetic and environmental factors play important roles in the pathogenesis of NIDDM. Cumulative evidence on the high prevalence of NIDDM in certain ethnic groups, the high concordance rate for the disease in monozygotic twins, familial aggregation, and familial transmission patterns suggests that the genetic component plays an important etiological role in the development of NIDDM. In genetically predisposed individuals, there is a slow progression from a normal state to hyperglycemia, largely due to a combination of insulin resistance and defects in insulin secretion. Although numerous candidate genes responsible for insulin resistance and for the defects in insulin secretion have been reported, no specific gene(s) accounting for the majority of cases of the common type of NIDDM has been identified. Considerable evidence indicates that environmental and other factors, including diet, stress, physical activity, obesity and aging, also play an important role in the development of the disease. In conclusion, the pathogenic process of NIDDM depends on a complex interaction between genetic and environmental factors.

Journal Article↗
PubMed1996

Laparoscopic Paraaortic Lymph Node Dissection in Patients with Gynecologic Malignancies

Accurate evaluation of the paraaortic lymph node is important in planning treatment of gynecologic malignancies. Because radiologic methods to detect occult paraaortic lymph node metastases are inaccurate and staging requires a major surgical procedure, we investigated the feasibility of laparoscopic paraaortic lymph node dissection in our preliminary series of five women (3 stage IIb cervical cancer, 1 stage Ib cervical cancer, 1 ovarian cancer). Three patients with stage Ib cervical cancer scheduled for primary radiotherapy underwent selective paraaortic lymph node biopsy only. We performed laparoscopic radical hysterectomy with pelvic lymphadenectomy in the patient with stage Ib disease, in addition to paraaortic lymph node dissection. The average operating time for lymph node dissection was 125 minutes and mean estimated blood loss was 250 ml. The average number of lymph nodes removed was 3.6. We conclude that this laparoscopic procedure is feasible and helps guide the management of these patients.

Journal Article↗