Biomedical subjects

Kaoruko Haneda

Publications and source records attributed to Kaoruko Haneda.

4 recordsLinked to original sources

PubMed2006

Hemodynamic and electrophysiological relationship involved in human face processing: evidence from a combined fMRI-ERP study.

Functional magnetic resonance imaging (fMRI) and event-related potential (ERP) experiments were conducted in the same group of subjects and with an identical task paradigm to investigate a possible relationship between hemodynamic and electrophysiological responses within the brain. The subjects were instructed to judge whether visually presented stimuli were faces or houses and then press the corresponding button. Functional MRI identified face- and house-related regions in the lateral and medial part of the fusiform gyrus, respectively, while ERP showed significantly greater N170 negativity for face than for house stimuli in the temporo-occipital electrodes. Correlation analysis between the BOLD signal in the fusiform gyrus and ERP parameters demonstrated a close relationship between the signal and both latency and amplitude of N170 across the subjects. These correlations may indicate that the variation in cognitive demand and hemodynamic responses during the face/house discrimination task is coupled with the variation of N170 peak latency/amplitude across the subjects. Thus, integrative analysis of spatial and temporal information obtained from the two experimental modalities may help in studying neural correlates involved in a particular cognitive task.

Adult↗

PubMed2005

Linking semantic priming effect in functional MRI and event-related potentials.

The aim of this study is to examine the neural substrates involved in semantic priming using a combined event-related functional magnetic resonance imaging (fMRI) and event-related potentials (ERP) study. Twelve subjects were instructed to judge whether the presented target word was a real word or a nonword. Under the related condition, target words were preceded by a semantically related prime word. On the other hand, under the unrelated condition, prime words did not have semantic relatedness with the target word. The reaction time for reaching a judgment was longer under the unrelated condition than under the related condition, indicating that the recognition of target words is promoted by semantic priming under the related condition. In the fMRI results, we found reduced activity in the dorsal and ventral left inferior frontal gyrus, the anterior cingulate, and left superior temporal cortex for related versus unrelated conditions (i.e., the repetition suppression effect). ERP analysis revealed that the amplitude of the N400 component was reduced under the related condition compared with the unrelated condition (i.e., the N400 priming effect). Correlation analysis between the BOLD repetition suppression effect and the N400 priming effect decomposed by independent component analysis (ICA) across subjects showed significant correlation in the left superior temporal gyrus. This finding is consistent with the recent MEG data suggesting that the source of N400 is judged to be the bilateral superior temporal lobe. We discussed this finding herein in relation to the modulation of access to the phonological representation caused by semantic priming.

Adult↗

PubMed2004

Functional association of the amygdala and ventral prefrontal cortex during cognitive evaluation of facial expressions primed by masked angry faces: an event-related fMRI study.

The present study examined the functional association of the amygdala and right ventral prefrontal cortex (PFC) during cognitive evaluation of facial expressions. A situation was created where emotional valence of the stimuli was unconsciously manipulated by using subliminal affective priming. Twelve healthy volunteers were asked to evaluate the facial expressions of a target face (500-ms duration) such as "anger", "neutral", or "happy". All target faces expressed relatively weak anger. Just before the presentation of the target face, a prime of three conditions of 35-ms duration, angry face, neutral face, and white blank was presented. The subjects could not consciously identify the primes in this procedure. Activity in the right amygdala was greater with subliminal presentation of the angry prime compared with subliminal presentation of a neutral face or white-blank stimuli. Most importantly, the degree of activation of the right amygdala was negatively correlated with that of the right ventral PFC only with the anger prime. Furthermore, activation of the amygdala was positively correlated with rate of judgment when the subjects recognized anger in the target faces. These results are discussed in terms of the functional association between the right PFC and the amygdala and its influence on cognitive processing.

Adult↗

PubMed2003

Interaction of prime and target in the subliminal affective priming effect.

It has been found that an emotional stimulus such as a facial expression presented subliminally can affect subsequent information processing and behavior, usually by shifting evaluation of a subsequent stimulus to a valence congruent with the previous stimulus. This phenomenon is called subliminal affective priming. The present study was conducted to replicate and expand previous findings by investigating interaction of primes and targets in the affective priming effect. Two conditions were used. Prime (subliminal presentation 35 msec.) of an angry face of a woman and a No Prime control condition. Just after presentation of the prime, an ambiguous angry face or an emotionally neutral face was presented above the threshold of awareness (500 msec.). 12 female undergraduate women judged categories of facial expressions (Anger, Neutral, or Happiness) for the target faces. Analysis indicated that the Anger primes significantly facilitated judgment of anger for the ambiguous angry faces; however, the priming effect of the Anger primes was not observed for neutral faces. Consequently, the present finding suggested that a subliminal affective priming effect should be more prominent when affective valence of primes and targets is congruent.

Adult↗