Bladder obstruction in monochorionic monoamniotic twins.
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Biomedical subjects
Karen L Koscica
Publications and source records attributed to Karen L Koscica.
The effect of phosphoramidon on inflammation-mediated preterm delivery in a mouse model.
OBJECTIVE: Several metallopeptidases have been implicated in both term and preterm parturition. We hypothesize that endotoxin-induced preterm delivery can be prevented by the administration of a metallopeptidase inhibitor. STUDY DESIGN: We used an animal model of endotoxin-induced preterm delivery in timed pregnancy C57Bl/6 mice. Test animals received lipopolysaccharide followed by phosphoramidon, either every 1.5 or every 3 hours. Control mice received lipopolysaccharide followed by buffer injections at the same intervals. The primary outcome was a preterm delivery rate. RESULTS: The rate of preterm delivery for the control animals was 88.0% compared with the treatment groups of 45.5% for the mice that received phosphoramidon every 3 hours and 30.8% for the group that received it every 1.5 hours (P<.01). CONCLUSION: The administration of a metallopeptidase inhibitor resulted in a decreased rate of preterm delivery in this animal model.
Animals↗
Are maternal serum troponin I levels affected by vaginal or cesarean delivery?
Our objective was to describe the change in the level of troponin I in patients who undergo a vaginal or cesarean delivery. We obtained troponin I levels on admission and 1 hour after delivery in women undergoing vaginal and cesarean deliveries. Exclusion criteria included <37 weeks' gestation, a history of cardiac disease, hypertension, or cardiac symptoms. The troponin I level used to indicate myocardial ischemia was 2.0 ng/mL; levels were analyzed using the Wilcoxon test. The median age of women in the vaginal versus the cesarean group were 25.6 years and 34.4 years, and the median gestational age for both groups was 39.6 weeks. The median troponin I level before and after vaginal delivery was <0.3 ng/mL and before and after cesarean was <0.3 ng/mL. The highest level of troponin I in either group was 0.3 ng/mL. Troponin I is not elevated as a result of undergoing a vaginal or cesarean delivery. We conclude that troponin I may be used as a reliable marker to diagnose myocardial ischemia in postpartum women.
Adult↗