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Biomedical subjects

Karin Rasmussen

Publications and source records attributed to Karin Rasmussen.

5 recordsLinked to original sources
PubMed2006

[Cranial diabetes insipidus in Wegener's granulomatosis].

We describe three cases of cranial diabetes insipidus (CDI) caused by Wegener's granulomatosis (WG). Panhypopituitarism was the presenting symptom in one patient. Magnetic resonance imaging (MRI) showed enlargement of the pituitary gland with an intrasellar mass lesion and absence of posterior pituitary lobe hyperintensity. Follow-up MRI disclosed reduction of the intrasellar lesion but sustained loss of posterior lobe hyperintensity. The patients still have CDI despite a marked clinical response to the treatment of WG. Pituitary dysfunction may be the presenting symptom as well as a complication of WG.

Diabetes Insipidus, Neurogenic↗
PubMed2005

[Somatostatin receptor scintigraphy].

Somatostatin receptor scintigraphy (SRS) is a very valuable imaging technique for visualisation of a diversity of neuroendocrine tumours. The sensitivity for localisation of carcinoid tumours is high, but somewhat lower for other neuroendocrine tumours. The methodology, multiple clinical aspects and limitations of the examination are described. The value of the method in patients with non-neuroendocrine tumours has yet to be established. The development of new radio-labelled somatostatin analogues for diagnosis and treatment is briefly discussed.

Endocrine Gland Neoplasms↗
PubMed2004

Arterial concentration of 99mTc-sestamibi at rest, during peak exercise and after dipyridamole infusion.

Tracers for myocardial perfusion imaging during stress should not only have high cardiac uptake but they should also have a fast blood clearance to prevent myocardial tracer uptake after the ischaemic stimulus. The present study characterize the early phase of the arterial (99m)Tc-sestamibi (MIBI) time-activity curve after venous bolus injection at rest, during peak exercise and after dipyridamole infusion. We included 11 patients undergoing angioplasty for one-vessel disease (rest study) and 20 patients evaluated for the detection of haemodynamic significant coronary stenoses by (99m)Tc-sestamibi single photon emission computed tomography (SPECT) using either bicycle exercise testing (10 patients) or standard dipyridamole testing (10 patients). Arterial blood samples of 1 ml were taken from the left femoral artery (rest study) or the right radial artery (exercise and dipyridamole studies) every 5 s during the first 5 min postinjection. In the exercise and the dipyridamole studies blood sampling were extended to include blood samples every 5 min 5-30 min postinjection. Peak MIBI concentration was lower and decrease in concentration slower after tracer injection during exercise than during dipyridamole stress testing. This may cause an underestimation of perfusion defects during exercise because of MIBI uptake after the ischaemic stimulus. The implications of the study not only refer to the choice of stress modality when using MIBI. This study also underlines the importance of considering early blood clearance in addition to regional myocardial tracerkinetic aspects such as myocardial extraction fraction when new tracers are introduced.

Arteries↗
PubMed2003

[Adrenal scintigraphy].

Adrenal scintigraphy is a functional imaging technique for evaluation of adrenal gland hyperfunction. In this review the methodology and multiple applications of the examination are described. The role of scintigraphy in the light of the relatively high radiation dose to the patient is defined and compared with other imaging modalities. The request for a thorough biochemical and anatomical evaluation prior to scintigraphy is emphasized in order to achieve accurate interpretation. Abnormal imaging patterns and the interpretation criterion are discussed.

Adrenal Gland Diseases↗